[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650700":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":12,"collaborators":10,"id":16,"slug":17,"hasResults":18,"nctId":19,"briefTitle":20,"officialTitle":21,"acronym":22,"eligibilityCriteria":23,"healthyVolunteers":24,"sex":25,"minAge":26,"maxAge":10,"enrollmentInfo":27,"targetDuration":30,"studyType":31,"phases":10,"briefSummary":32,"conditions":33,"keywords":10,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"• Arm 1: Osteoarthritis • Arm 2: Ankylosing spondylitis • Arm 3: Healthy controls",null,"Three analytical study arms: OA, AS, and control groups.",{"type":13,"investigatorFullName":14,"investigatorTitle":15,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Menna Allah Nashaat","Principal Investigator","100650700","15-hydroxyprostaglandin-dehydrogenase-in-osteoarthritis-and-ankylosing-spondylitis-100650700",false,"NCT07751263","15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis","15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis: Associations With Clinical and Musculoskeletal Ultrasound Features.","HPGD-OA-AS-US","Inclusion Criteria:\n\n* Inclusion criteria\n\n  * Adults aged 18 years or older. AxSpA group Patients diagnosed as ankylosing spondylitis according to ASAS criteria . R OA group\n\n    * Adults with osteoarthritis Diagnosed according to the American College of Rheumatology classification criteria.\\[8\\]R ACR Clinical classification criteria for Osteoarthritis of the hip ACR Clinical classification criteria for Osteoarthritis of the knee ACR Clinical classification criteria for Osteoarthritis of the hand Control group Age- and sex-matched healthy controls.\n\nExclusion Criteria:\n\n* • Other inflammatory arthritides such as psoriatic arthritis, gout, or SLE-related arthritis.\n\n  * Septic arthritis or suspected joint infection.\n  * Recent intra-articular steroid injection if it may influence biomarker results.\n  * Any major systemic illness likely to affect biomarker measurement or ultrasound interpretation.\n  * Patients received certain drugs as non-steroidal anti-inflammatory drugs (NSAIDs)",true,"ALL","18 Years",{"count":28,"type":29},51,"ESTIMATED","1 Year","OBSERVATIONAL","To evaluate serum and synovial fluid 15-PGDH levels in patients with osteoarthritis and ankylosing spondylitis and determine their associations with clinical and musculoskeletal ultrasound features.\n\nTo compare 15-PGDH concentrations among patients with knee osteoarthritis, and ankylosing spondylitis with knee effusion\n\nTo evaluate whether serum 15-PGDH reflects intra-articular 15-PGDH concentrations.\n\nAnalysis the level of 15-PGDH in relation to disease activity and severity of both diseases.",[34,35],"Osteoarthritis","Ankylosing Spondylitis","NOT_YET_RECRUITING","2026-08-03",{"date":39,"type":40},"2026-08-07","ACTUAL",{"date":42,"type":29},"2026-08-02",{"date":44,"type":29},"2028-08-02",{"name":5,"class":6}]