[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648223":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":25,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Norepinephrine 5-mcg group","ACTIVE_COMPARATOR","The study drug will be prepared by diluting 4000 mcg of NE in 400 mL of normal saline to achieve a concentration of 10 mcg\u002FmL. The assigned dose (5 mcg, 0.5 mL of the prepared solution) will then be further diluted with normal saline in a 10-mL syringe.",[13],"Drug: Norepinephrine 5 mcg",{"label":15,"type":10,"description":16,"interventionNames":17},"Norepinephrine 10-mcg group","The study drug will be prepared by diluting 4000 mcg of NE in 400 mL of normal saline to achieve a concentration of 10 mcg\u002FmL. The assigned dose (10 mcg, 1 mL of the prepared solution) will then be further diluted with normal saline in a 10-mL syringe.",[18],"Drug: Norepinephrine 10 mcg",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Norepinephrine 10 mcg","Norepinephrine dose of 10 mcg will be given if patient developed hypotension (mean arterial pressure \\\u003C65 mmHg). The norepinephrine bolus (10 mcg) will be repeated if mean arterial pressure is not restored within 2 min. Norepinephrine infusion will be started if hypotension persisted after three boluses.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Norepinephrine 5 mcg","Norepinephrine dose of 5 mcg will be given if patient developed hypotension (mean arterial pressure \\\u003C65 mmHg). The norepinephrine bolus (5 mcg) will be repeated if mean arterial pressure is not restored within 2 min. Norepinephrine infusion will be started if hypotension persisted after three boluses.",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Maha Mostafa, MD","CONTACT","+201000365115","maha.mostafa@cu.edu.eg",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Cairo","Cairo Governorate","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.24967,30.06263,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":52,"phoneExt":25,"email":53},"ahmed Hasanin, Lecturer","+2010095076954","ahmedmohamedhasanin@gmail.com",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ahmed Hasanin","Professor","100648223","5-versus-10-mcg-norepinephrine-bolus-in-treatment-of-postinduction-and-early-intraoperative-hypotension-in-emergency-abdominal-surgery-100648223",false,"NCT07719075","5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery","Comparing 5 mcg and 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients, American Society of anesthesiologists (ASA) I-III undergoing emergency abdominal surgery\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 45%, heart block, arrhythmias, tight valvular lesions)\n* Patients on vasopressor infusion,\n* Pregnant or lactating women,\n* Allergy of any of the study drugs","ALL","21 Years","65 Years",{"count":69,"type":70},136,"ESTIMATED","INTERVENTIONAL",[73],"NA","Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment. Because it can lead to serious organ injury, prompt prevention and management are essential. Vasopressors, including ephedrine, phenylephrine, and norepinephrine, are commonly used, with NE gaining interest as an intraoperative bolus despite uncertainty about the optimal dose in general surgery population The aim of this study is to compare 5 mcg to 10 mcg norepinephrine bolus for treatment of postinduction hypotension and early intraoperative in emergency abdominal surgery.",[76,77,78],"Hypotension on Induction","Emergency Surgery","Norepinephrine",[80,81,82],"hypotension","norepinephrine","emergency surgery","2026-08-04",{"date":85,"type":86},"2026-08-05","ACTUAL",{"date":83,"type":86},{"date":89,"type":70},"2026-12",{"name":5,"class":6},1]