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5DW",{"type":71,"coordinates":3481},[3482,3483],-3.52751,50.7236,{"lat":3483,"lon":3482},[3486],{"name":78,"role":58,"phone":3487,"phoneExt":34,"email":34},"+4401392402869",{"facility":3489,"status":64,"city":3490,"state":3491,"zip":3492,"country":3452,"countryCode":3453,"cosmosGeoPoint":3493,"geoPoint":3497,"contacts":3498},"Queen Elizabeth Hospital Birmingham ( Site 0923)","Birmingham","England","B15 2TH",{"type":71,"coordinates":3494},[3495,3496],-1.89983,52.48142,{"lat":3496,"lon":3495},[3499],{"name":78,"role":58,"phone":3500,"phoneExt":34,"email":34},"+441216272000",{"facility":3502,"status":64,"city":3503,"state":3504,"zip":3505,"country":3452,"countryCode":3453,"cosmosGeoPoint":3506,"geoPoint":3510,"contacts":3511},"Mount Vernon Hospital ( Site 0921)","Northwood","Hillingdon","HA6 2RN",{"type":71,"coordinates":3507},[3508,3509],-0.42454,51.61162,{"lat":3509,"lon":3508},[3512],{"name":78,"role":58,"phone":3513,"phoneExt":34,"email":34},"0203 826 2020",{"facility":3515,"status":64,"city":3464,"state":3516,"zip":3517,"country":3452,"countryCode":3453,"cosmosGeoPoint":3518,"geoPoint":3520,"contacts":3521},"St Bartholomew s Hospital ( Site 0925)","London, City of","EC1A 7BE",{"type":71,"coordinates":3519},[3469,3470],{"lat":3470,"lon":3469},[3522],{"name":78,"role":58,"phone":3523,"phoneExt":34,"email":34},"020 7377 7000",{"facility":3525,"status":64,"city":3526,"state":3516,"zip":3527,"country":3452,"countryCode":3453,"cosmosGeoPoint":3528,"geoPoint":3532,"contacts":3533},"Royal Marsden Hospital (Sutton) ( Site 0922)","Sutton","SM2 5PT",{"type":71,"coordinates":3529},[3530,3531],-0.2,51.35,{"lat":3531,"lon":3530},[3534],{"name":78,"role":58,"phone":3535,"phoneExt":34,"email":34},"+4402087224191",{"facility":3537,"status":64,"city":3478,"state":3452,"zip":3538,"country":3452,"countryCode":3453,"cosmosGeoPoint":34,"geoPoint":34,"contacts":3539},"Torbay Hospital ( Site 0918)","TQ2 7AA",[3540],{"name":78,"role":58,"phone":3541,"phoneExt":34,"email":34},"+441803656615",{"type":3543,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[3545],{"name":3546,"class":6},"Daiichi Sankyo","100587234","a-clinical-study-of-ifinatamab-deruxtecan-i-dxd-in-people-with-metastatic-prostate-cancer-mk-2400-001-100587234",false,"NCT06925737","A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)","A Phase 3, Open-label Study of Ifinatamab Deruxtecan Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (IDeate-Prostate01)","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has histologically- or cytologically-confirmed adenocarcinoma of the prostate without small cell histology\n* Has prostate cancer progression while on androgen deprivation therapy (ADT) (or post bilateral orchiectomy) within 6 months prior to Screening\n* Has current evidence of distant metastatic disease (M1 disease) documented by either bone lesions on bone scan and\u002For soft tissue disease by computed tomography (CT)\u002Fmagnetic resonance imaging (MRI)\n* Has received prior treatment with 1 or 2 androgen receptor pathway inhibitors (ARPIs) and progressed during or after at least 8 weeks of treatment\n* Has provided tumor tissue from a core or excisional biopsy from soft tissue not previously irradiated and obtained after disease progression on the most recent prior therapy\n* Has recovered from adverse events (AEs) due to previous anticancer therapies\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Is unable to swallow tablets\u002Fcapsules\n* Has any of the following indicators of interstitial lung disease (ILD)\u002Fpneumonitis:\n\n  1. Has any history of ILD\u002Fpneumonitis that required steroid use, except for a history of radiation pneumonitis that did not require steroids\n  2. Has current ILD\u002Fpneumonitis\n  3. Has a clinical or radiographic suspicion of ILD for which the diagnosis of ILD cannot be ruled out\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses\n* Has uncontrolled or significant cardiovascular disease\n* Has received prior treatment with a taxane-based chemotherapy agent for metastatic castration-resistant prostate cancer (mCRPC)\n* Has had prior discontinuation of an antibody drug conjugate (ADC) that consists of an exatecan derivative (eg, trastuzumab deruxtecan) due to treatment-related toxicities\n* Has a \"superscan\" bone scan","MALE","18 Years",{"count":3557,"type":3558},1440,"ESTIMATED","INTERVENTIONAL",[3561],"PHASE3","Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if people who receive I-DXd live longer overall and live longer without the cancer growing or spreading than people who receive chemotherapy.",[3564,3565],"Prostate Cancer","Prostatic Neoplasms","2026-08-20",{"date":3568,"type":3569},"2026-08-21","ACTUAL",{"date":3571,"type":3569},"2025-05-13",{"date":3573,"type":3558},"2031-01-06",{"name":5,"class":6},294]