[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647556":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":10,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":60,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":78,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":88,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Huashan Hospital","OTHER",[8,13,17],{"label":9,"type":10,"description":10,"interventionNames":11},"AI model development",null,[12],"Other: Retrospective data collection",{"label":14,"type":10,"description":10,"interventionNames":15},"Prospective nutritional intervention",[16],"Other: Prospective data collection",{"label":18,"type":10,"description":10,"interventionNames":19},"External validation",[20],"Other: External validation",[22,26,30],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Retrospective data collection","Retrospective data from the maintenance hemodialysis cohort at Huashan Hospital (Sept 2018-Sept 2025) include:\n\nDemographics: age, sex, education, smoking\u002Falcohol, primary disease, dialysis vintage.\n\nDialysis treatment: repeated measures of weight, BP, heart rate, arterial\u002Fvenous\u002Ftransmembrane pressures, ultrafiltration rate, session time, dialyzer type, blood flow, and medications.\n\nComplication control:Nutrition: lipids, glucose, prealbumin, albumin, BMI, nPCR;Bone mineral: Ca, P, PTH, 25(OH)D₃;CVD: coronary calcification score, echocardiography, brain MRI, ECG;Inflammation: ferritin, CRP;Anemia: Hb, Fe, TIBC, TSAT;Acid-base \\& electrolytes: CO₂CP, Mg, K, Na, Cl .\n\nRenal filtration:Cr, BUN, UA,β₂-MG, NT-proBNP, urine output. Neuropsychology: quality-of-life and symptom scores. Comorbidities: diabetes, CVD, hypertension,etc. Physical function: frailty score, ADL, comprehensive geriatric assessment. Medications: anticoagulants, ESA, etc. Diagnosis: ICD-10 codes, diagnosis date,etc.",[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Prospective data collection","Research data are primarily derived from the prospective CKD cohort at Huashan Hospital Integrated CKD Management Clinic.\n\nBaseline includes: age, sex, education, smoking\u002Falcohol, primary disease.\n\nFollow-up (every 3 months):\n\n3-day diet diary (via app\u002Fpaper) to calculate P\u002FCa\u002Fprotein intake; indirect calorimetry for resting energy expenditure; nutritional supplement use.\n\nPhysical: handgrip, gait speed (sarcopenia), DEXA bone density. Questionnaires: frailty, ADL, QoL, symptom scores. Labs (repeated): bone mineral (Ca, P, PTH, 25-OH-D₃), CRP, anemia panel, small\u002Fmiddle toxins (Cr, BUN, UA, β₂-MG), BNP.\n\nImaging: coronary calcification score, echocardiography, brain MRI (for cerebrovascular risk).\n\nRenal filtration: repeated Cr, BUN, UA, β₂-MG, NT-proBNP, urine output.",[14],{"type":6,"name":18,"description":31,"armGroupLabels":32,"otherNames":10},"The research data are primarily based on the previously established community-based chronic kidney disease (CKD) cohort at Shanghai Fifth People's Hospital and the end-stage renal disease (ESRD) cohort at Shanghai Jing'an District Central Hospital, which serve as external validation and the data contents are the same as the retrospective data collection.",[18],[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Jing Chen","CONTACT","862152888050","chenjing1998@fudan.edu.cn",[40],{"facility":41,"status":10,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Huashan Hospital, Fudan University","Shanghai","Shanghai Municipality","200040","China","CN",{"type":48,"coordinates":49},"Point",[50,51],121.45806,31.22222,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":37,"phoneExt":10,"email":38},"Jing (靖) Chen",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chen Jing","Professor and Chief Physician",[61,64],{"name":62,"class":63},"Jingan District Central Hospital of Shanghai (Jingan Branch of Huashan Hospital Affiliated to Fudan University)","UNKNOWN",{"name":65,"class":63},"Fudan University Affiliated Shanghai Fifth People's Hospital Hospital","100647556","a-cohort-study-on-the-integrated-management-of-chronic-kidney-disease-100647556",false,"NCT07712341","A Cohort Study on the Integrated Management of Chronic Kidney Disease","Inclusion Criteria:\n\nProspective:\n\n* Patients who have documented outpatient or inpatient records at Huashan Hospital, Shanghai Fifth People's Hospital, or Jing'an District Central Hospital during the period from September 2018 to September 2025.\n* Aged 18-90 years.\n* Diagnosed with one or more of the 48 pre-specified common chronic diseases according to ICD-10 codes.\n* Patients diagnosed with end-stage renal disease (CKD stage 5) and receiving long-term maintenance hemodialysis, with a dialysis vintage of at least 3 months.\n* Have relatively complete hemodialysis records available at the participating center.\n\nRetrospective:\n\n* Patients who meet the diagnostic criteria for chronic kidney disease (CKD) stages 1-5 (non-dialysis) as defined by the KDIGO guidelines, with a disease duration of at least 3 months.\n* Aged 18-80 years, with normal cognitive ability to independently, or with the assistance of a caregiver, complete dietary diaries and quantitative assessments, and willing to provide written informed consent voluntarily.\n* Able to comply with regular outpatient follow-up visits and willing to record a 3-day dietary diary (including both weekdays and weekends) as required.\n\nExclusion Criteria:\n\nProspective:\n\n* Patients whose dialysis-related data and key clinical variables (e.g., creatinine, proteinuria, and other outcome-related indicators) are missing or severely illogical, and which are deemed unusable for research purposes upon evaluation.\n* Patients with poor compliance during dialysis, or those receiving palliative dialysis.\n* Other conditions that the investigators consider inappropriate.\n\nRetrospective:\n\n* Patients who have experienced acute kidney injury within 3 months prior to enrollment, or who are in an acute stress state such as acute infection, myocardial infarction, or other acute conditions at the time of screening.\n* Patients with severe cognitive impairment, mental illness, or insurmountable communication barriers that prevent accurate provision of metabolic assessment information.\n* Pregnant or lactating women; patients currently participating in other drug interventional clinical trials that may interfere with the outcome assessment of this study.","ALL","18 Years","90 Years",{"count":76,"type":77},4029,"ESTIMATED","2 Years","OBSERVATIONAL","The study will leverage the established multi-stage cohort resources at Huashan Hospital, covering the entire spectrum from early-stage CKD to dialysis, including a comorbidity real-world database, a prospective CKD patient cohort, and a maintenance hemodialysis patient real-world cohort. It will also collaborate with the Shanghai Fifth People's Hospital (community-based CKD cohort, n\\>2,000) and the Jing'an District Central Hospital (end-stage renal disease cohort, n\\>400) as external validation platforms. Using epidemiological and big data-driven approaches, the study aims to elucidate the mechanisms underlying disease progression and complications, construct intelligent intervention models, and validate their performance in the external cohorts, ultimately facilitating the optimization and broader application of comprehensive CKD management strategies.",[82,83,84],"Chronic Kidney Disease, Stage 5","Chronic Kidney Disease, Stage 4","Chronic Kidney Disease, Stage 3",[86,87],"Chronic Kidney Disease","dialysis","NOT_YET_RECRUITING","2026-07-14",{"date":91,"type":92},"2026-07-17","ACTUAL",{"date":94,"type":77},"2026-09-01",{"date":96,"type":77},"2028-08-30",{"name":5,"class":6},1]