[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649835":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":59,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":63,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":25,"overallStatus":81,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Opioid-Based Anaesthesia (OBA)","ACTIVE_COMPARATOR","Participants will receive conventional fentanyl-based anaesthesia during surgery in addition to standardized general anaesthesia.",[13],"Drug: Fentanyl-Based Anesthesia",{"label":15,"type":10,"description":16,"interventionNames":17},"Opioid-Free Anaesthesia (OFA) Group","Participants will receive opioid-free anaesthesia consisting of dexmedetomidine, ketamine, and lidocaine administered as loading doses followed by continuous intravenous infusions during surgery, in addition to standardized general anaesthesia.",[18],"Drug: Opioid-Free Anaesthesia (Dexmedetomidine, Ketamine, and Lidocaine)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Fentanyl-Based Anesthesia","Fentanyl will be administered intravenously as the opioid component of balanced general anaesthesia.\n\nLoading dose of 2 mic\u002Fkg I.V. followed by continuous infusion of three syringes, one with fentanyl infusion 0.5mic\u002Fkg\u002Fhr, and two syringes with normal saline.\n\nwill receive IV acetaminophen (1 g) and ketrolac 30mg 10 minutes before incision closure.\n\nPostoperative Analgesia: All patients will receive IV acetaminophen 1 g \u002F8h, ketrolac 30 mg\u002F8h and rescue doses of pethideine 0.5 mg\u002Fkg IM if VAS score is ≥ 4.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Opioid-Free Anaesthesia (Dexmedetomidine, Ketamine, and Lidocaine)","Dexmedetomidine: Loading dose of 1 µg\u002Fkg IV over 10 min before induction, followed by continuous infusion at 0.4 µg\u002Fkg\u002Fh .\n\nKetamine: Loading dose of 0.25mg\u002Fkg followed by continuous infusion of ketamine at 0.1mg\u002Fkg\u002Fhr .\n\nLidocaine: loading dose of 1.5mg\u002Fkg\u002Fhr followed by maintainance of 1mg\u002Fkg\u002Fhr. All three infusions to be stopped 30 minutes before skin closure will receive IV acetaminophen (1 g) and ketrolac 30mg 10 minutes before incision closure.\n\nPostoperative Analgesia: All patients will receive IV acetaminophen 1 g \u002F8h, ketrolac 30 mg\u002F8h and rescue doses of pethideine 0.5 mg\u002Fkg IM if VAS score is ≥ 4.",[15],[31],{"name":32,"affiliation":33,"role":34},"yomna Emad Youssef","Ainshams University Hospitals","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"yomna emad Youssef, MBBCH","CONTACT","01026616629","yomnaelsayed@med.asu.edu.eg",{"name":42,"role":38,"phone":43,"phoneExt":25,"email":44},"yomna emad youssef, MBBCH","01145211869","yomnayoussef95@gmail.com",[46],{"facility":47,"status":25,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":25},"Ain Shams","Cairo","Abbasia","00202","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.24967,30.06263,{"lat":57,"lon":56},{"type":60,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100649835","a-comparative-study-between-opioid-free-general-anaesthesia-and-opioid-based-general-anaesthesia-on-the-quality-of-recovery-in-patients-undergoing-elective-laparoscopic-hystrectomy-a-randomized-trial-100649835",false,"NCT07739641","A COMPARATIVE STUDY BETWEEN OPIOID-FREE GENERAL ANAESTHESIA AND OPIOID-BASED GENERAL ANAESTHESIA ON THE QUALITY OF RECOVERY IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC HYSTRECTOMY: A Randomized Trial","Inclusion Criteria:\n\n* Undergoing a scheduled laparoscopic hysterectomy surgery under general anaesthesia.\n* Age group: 40-65 years old.\n* BMI\\\u003C35.\n* ASA I-II.\n\nExclusion Criteria:\n\n* Emergency hysterectomy.\n* Allergy to any of the drugs used in the study.\n* HR \\\u003C 50 bpm (chronic treatment by beta blockers, heart block patients).\n* Alcohol or drug abuse.\n* Psychiatric disease.\n* Liver impairment. Kidney impairment","FEMALE","40 Years","65 Years",{"count":71,"type":72},66,"ESTIMATED","INTERVENTIONAL",[75],"NA","the intent of this study To compare the efficacy of opioid free general anaesthesia versus opioid based general anaesthesia to achieve enhanced recovery regarding post-operative pain and post-operative nausea and vomiting episodes in patients undergoing elective laparoscopic hysterectomy",[78,79,80],"Post Operative Recovery","Post Operative Nausea and Vomiting (PONV)","Post Operative Analgesia","NOT_YET_RECRUITING","2026-07-27",{"date":84,"type":85},"2026-07-31","ACTUAL",{"date":87,"type":72},"2026-08-22",{"date":89,"type":72},"2027-04-20",{"name":5,"class":6},1]