[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652848":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":49,"collaborators":53,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":83,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Singapore National Eye Centre","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","SHAM_COMPARATOR","Participants will be provided with a pair of spectacles fitted with plano single vision lenses according to the assigned study intervention.",[13],"Device: Single Vision Lenses",{"label":15,"type":16,"description":17,"interventionNames":18},"Zeiss MyoActive Lenses","EXPERIMENTAL","Participants will be provided with a pair of spectacles fitted with plano MyoActive lenses according to the assigned study intervention.",[19],"Device: Zeiss MyoActive lenses",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Zeiss MyoActive lenses","The novel ZEISS MyoActive lens was designed to introduce simultaneous myopic defocus at the retina. Early studies, including interim results from the ongoing trial NCT06563700, have shown promise in reducing myopia progression in already-myope children. However, its utility in pre-myopic children remains underexplored, and no current optical strategy has been validated for delaying the transition from pre-myopia to clinical myopia.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Single Vision Lenses","Patients will be fitted with a pair of plano single vision glasses.",[9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Dr Foo Li Lian","CONTACT","+6596572880","foo.li.lian@singhealth.com.sg",[38],{"facility":5,"status":26,"city":39,"state":26,"zip":26,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Singapore","SG",{"type":42,"coordinates":43},"Point",[44,45],103.85007,1.28967,{"lat":45,"lon":44},[48],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Foo Li Lian","Clinical Director, Myopia Service, Singapore National Eye Centre, Myopia Centre of Excellence Singapore Clinical Assistant Professor, DUKE-NUS Graduate Medical School Consultant Ophthalmologist, Singapore National Eye Centre Myopia Program Lead, SNEC",[54,57],{"name":55,"class":56},"Duke-NUS Graduate Medical School","OTHER",{"name":58,"class":59},"ZEISS Vision Care","INDUSTRY","100652848","a-pilot-evaluation-of-refractive-error-progression-in-pre-myopic-children-in-singapore-with-and-without-myopia-control-spectacles-100652848",false,"NCT07779941","A Pilot Evaluation of Refractive Error Progression in Pre-Myopic Children in Singapore With and Without Myopia Control Spectacles","Inclusion Criteria\n\nParticipants enrolled in the trial must:\n\n1. be accompanied by a parent or guardian who is able to read and comprehend English and sign a record of informed consent\u002Fassent;\n2. be able to understand and participate in the Assent process;\n3. at baseline, be within the age range of 6 to 12 years old inclusive;\n4. No prior spectacle correction\n5. Cycloplegic spherical equivalent (SE) 0.00 to + 2.00 D\n6. Astigmatism of less than -1.50D\n7. Anisometropia of not more than 1.50D\n8. At least 1 parent or more with myopia\n\nExclusion Criteria\n\nParticipants enrolled in the trial must NOT have:\n\n* Any pre-existing systemic or ocular condition, including infection or disease that is likely to affect visual acuity and refractive error;\n* Any systemic disease that adversely affects ocular health e.g. diabetes, Graves disease, and auto-immune diseases such as ankylosing spondylitis, multiple sclerosis, Sjögrens syndrome and systemic lupus erythematosus.\n* Use of or a need for any systemic medication or topical medications which may alter normal ocular findings \u002F are known to affect a participant's ocular health \u002F physiology in an adverse or beneficial manner at enrolment and\u002For during the study. NB: Systemic antihistamines are allowed on an \"as needed basis\", provided they are not used prophylactically during the trial and at least 24 hours before the study product is used.\n* History of eye trauma\n* Amblyopia\n* Strabismus\n* History of any form of optical correction\n* Any concomitant myopia control treatment including atropine eyedrops, contact lenses or other myopia control glasses.\n\nThe Investigator may, at their discretion, exclude anyone who they believe may not be able to fulfil the study requirements or it is believed to be in the participant's best interests.",true,"ALL","6 Years","12 Years",{"count":71,"type":72},124,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study aims to find out whether ZEISS MyoActive lenses can help prevent short-sightedness from developing in children. We aim to recruit at least 50 children in total for this study.\n\nMyopia (short-sightedness) is becoming increasingly common in children worldwide. Early onset of myopia often leads to faster progression and a higher chance of developing high myopia, which increases the risk of serious eye conditions that can affect vision in adulthood, such as retinal detachment, glaucoma, and cataracts. Current treatments can slow the worsening of short-sightedness once children become myopic, but there is limited evidence on whether early intervention can delay myopia from developing in the first place.\n\nThis study will compare two types of commonly used spectacle lenses:\n\nZEISS MyoActive lenses, which are designed to provide a type of optical signal that may reduce the worsening of short-sightedness; and Standard single-vision lenses, which are the usual lenses prescribed for clear vision.\n\nChildren who join the study will be randomly assigned to wear one of these two lens types for 12 months. They will attend regular check-ups during this time so we can monitor their eye health and vision.\n\nBy randomly assigning children to one of these two lens types and following them over 12 months, we aim to determine whether ZEISS MyoActive lenses:\n\nreduce the likelihood of developing short-sightedness, slow changes in how short-sighted a child's eyes are becoming and eye growth, and are safe, comfortable, and well-tolerated for everyday use. The findings from this study may help improve early myopia prevention strategies and potentially reduce future risks of high myopia and its associated eye conditions.",[78,79],"Myopia","Pre-myopia",[81,82],"myopia","pre-myopia","NOT_YET_RECRUITING","2026-08-18",{"date":86,"type":87},"2026-08-21","ACTUAL",{"date":89,"type":72},"2026-08",{"date":91,"type":72},"2029-02",{"name":5,"class":6},1]