[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100445527":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":33,"locations":44,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":22,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":18,"enrollmentInfo":79,"targetDuration":18,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":47,"whyStopped":18,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Weill Medical College of Cornell University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Problem Adaptation Therapy for Pain (PATH-Pain)","EXPERIMENTAL","Problem Adaptation Therapy-PAIN (PATH-PAIN) is an emotion regulation intervention aimes to reduce stress and decrease depression and disability.",[13],"Behavioral: PATH-Pain",{"label":15,"type":16,"description":17,"interventionNames":18},"Attention Control Usual Care","NO_INTERVENTION","Usual Care involves the continued medical attention and treatment provided by the subject's physician and other medical professionals in primary care. This may include medical intervention or referrals to specialists to address issues of depression, pain or memory difficulties. Subjects will also be asked to meet with a study research assistant for structured interviews and educational sessions consisting of general questions regarding health habits and other non-medical topics unrelated to cognitive impairment, pain, and depression. Additionally, subjects will receive an educational booklet on pain and depression.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","PATH-Pain","The goals of PATH-Pain are to: 1) Teach problem solving skills to reduce negative emotions, by using emotion regulation and problem- solving strategies to overcome these difficulties. 2) Use compensatory strategies and environmental adaptation tools (notes, checklists, calendars, etc.) to avoid limitations resulting from memory problems, help improve emotion regulation, and create an easier environment to live in. If found helpful and participant agrees, a tablet application called WellPATH will be used to help the subject with emotion regulation techniques. The tablet will be given at the beginning of treatment and will be returned at the end of treatment. 3) Invite caregiver participation, when appropriate.\n\nSubjects in the PATH-PAIN group will receive 8 weekly sessions (first 8 weeks) with a study therapist and 6 monthly phone sessions (3 individual and 3 group) for 9-36 weeks. Each session will last approximately 50 minutes.",[9],[26,29,31],{"name":27,"affiliation":5,"role":28},"Dimitris Kiosses, PhD","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":5,"role":28},"Mannigton C Reid, MD",{"name":32,"affiliation":5,"role":28},"Lisa Ravdin, PhD",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"Dimtiris Kiosses, PhD","CONTACT","914-997-4381","dkiosses@med.cornell.edu",{"name":40,"role":36,"phone":41,"phoneExt":42,"email":43},"Laurie Evans, MS","914-682-9100","101-2570","lad9011@med.cornell.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Weill Cornell Medicine","RECRUITING","White Plains","New York","10502","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-73.76291,41.03399,{"lat":57,"lon":56},[60],{"name":61,"role":36,"phone":62,"phoneExt":18,"email":63},"Joanna Pantelides","914-997-5215","jop2285@med.cornell.edu",{"type":65,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[67],{"name":68,"class":69},"National Institute on Aging (NIA)","NIH","100445527","a-primary-care-based-psychosocial-intervention-to-improve-cognitive--depression-outcomes-in-older-adults-with-mci--early-stage-ad-100445527",false,"NCT05081596","A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD","PATH-Pain: A Primary Care-Based Psychosocial Intervention To Improve Cognitive and Depression Outcomes in Older Adults With MCI and Early Stage AD","Inclusion Criteria:\n\n* Age ≥ 60 years old\n* MCI or early stage probable or possible AD diagnosis (as defined by Albert et al or McKhann et al) al). Patients will have at least mild cognitive deficits defined by 16 ≤ MoCA ≤ 25.\n* Montgomery Asberg Depression Rating Scale (MADRS)\\[55\\] total ≥ 5, which reflects at least some mild depressive symptoms.\n* Participants will be off antidepressants, cholinesterase inhibitors or memantine or on a stable dosage for at least 12 weeks.\n* Chronic pain (neuropathic, nociceptive or mixed disorders): presence of pain on most days for at least 3 months and average pain intensity score \\>=4.\n* Clinical Dementia Rating 0.5 ≤ (CDR) ≤ 1.\n* Participant will have capacity to consent.\n* Participation of a study partner (e.g. caregiver\u002Ffamily member\u002Fsignificant other) is required.\n\nExclusion Criteria:\n\n* Deemed to have a significant suicide risk as assessed by site PI and clinical team.\n* Deemed too unstable medically or neurologically to safely enroll in a research trial.\n* Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy.\n* Requiring psychiatric hospitalization at baseline for safety.\n* Lack of English fluency.","ALL","60 Years",{"count":80,"type":81},100,"ESTIMATED","INTERVENTIONAL",[84],"NA","The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.",[87,88,89],"Depression","Pain","Cognitive Impairment",[91,92,93],"Older Adults","Mild Cognitive Impairment","Early Stage Alzheimer's Disease","2026-08-17",{"date":96,"type":97},"2026-08-20","ACTUAL",{"date":99,"type":97},"2022-06-03",{"date":101,"type":81},"2027-07-31",{"name":5,"class":6},1]