[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623239":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":23,"locations":31,"responsibleParty":65,"collaborators":10,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":93,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Heinrich-Heine University, Duesseldorf","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Post menopausal women with hormone replacement therapy",null,"Postmenopausal women who have been in menopause and have taken any hormone replacement therapy (HRT).",{"label":13,"type":10,"description":14,"interventionNames":10},"Post menopausal women without hormone replacement therapy (Control)","Postmenopausal women who have been in menopause and have not taken any hormone replacement therapy (HRT) These participants serve as the control cohort to compare outcomes against those receiving HRT.",[16,20],{"name":17,"affiliation":18,"role":19},"Malte Kelm, MD","Division of Cardiology, Pulmonary Disease and Vascular Medicine at University Hospital Duesseldorf","STUDY_DIRECTOR",{"name":21,"affiliation":18,"role":22},"Lisa Dannenberg, MD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+49 2118105187","lisaKristina.Dannenberg@med.uni-duesseldorf.de",{"name":29,"role":25,"phone":26,"phoneExt":10,"email":30},"Saskia Pietrucha, M.Sc.","saskia.pietrucha@med.uni-duesseldorf.de",[32,49],{"facility":33,"status":10,"city":34,"state":10,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Clinic for Cardiology, Angiology and Intensive Care at Charité Mitte Berlin","Berlin","Germany","DE",{"type":38,"coordinates":39},"Point",[40,41],13.41053,52.52437,{"lat":41,"lon":40},[44,48],{"name":45,"role":25,"phone":46,"phoneExt":10,"email":47},"Julia Lueg, MD","+49 30 450 613 174","ulia.lueg@dhzc-charite.de",{"name":45,"role":22,"phone":10,"phoneExt":10,"email":10},{"facility":50,"status":10,"city":51,"state":10,"zip":52,"country":35,"countryCode":36,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"University Hospital Duesseldorf","Düsseldorf","40225",{"type":38,"coordinates":54},[55,56],6.77927,51.22319,{"lat":56,"lon":55},[59,62,64],{"name":21,"role":25,"phone":60,"phoneExt":10,"email":61},"+492118118567","ctu@med.uni-duesseldorf.de",{"name":29,"role":25,"phone":63,"phoneExt":10,"email":61},"+ 49211 81 05187",{"name":21,"role":22,"phone":10,"phoneExt":10,"email":10},{"type":66,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100623239","a-prospective-multicenter-cohort-study-of-contemporary-menopausal-hormone-therapy-and-cardiovascular-outcomes-100623239",false,"NCT07394049","A Prospective Multicenter Cohort Study of Contemporary Menopausal Hormone Therapy and Cardiovascular Outcomes","Cardiovascular Assesment Under Current Hormone Replacement Therapy in Menopause (CATCH-Menopause)","CATCH-Menopaus","Inclusion Criteria:\n\n* female sex\n* Age 45-75 years at enrollment\n* Perimenopausal or postmenopausal status documented according to prespecified clinical criteria\n* Increased cardiovascular risk, defined as SCORE \\> 5 % (age 45-69 years) or SCORE2-OP \\> 5 % (age \\> 70 years), or established disease\n* Established cardiovascular disease includes coronary artery disease, cerebrovascular disease and\u002For peripheral artery disease, as specified in the approved protocol\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C45 years or \\> 75 years\n* Active malignancy at screening\n* Inability to provide written informed consent or to comply with study procedures\n* Severe renal impairment, defined as estimated glomerular filtrate rate \\\u003C30 ml\u002Fmin\u002F1.73m2, or dialysis dependance\n* Advanced liver disease, defined as Child-Pugh class C\n* Known genetic cardiomyopathiy",true,"FEMALE","45 Years","75 Years",{"count":80,"type":81},3408,"ESTIMATED","OBSERVATIONAL","This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women. Menopause-related estrogen deficiency leads to metabolic and vascular changes that increase atherosclerosis and cardiovascular events. This study hypothesizes that new HRT forms may reduce cardiovascular risk in high-risk women.\"",[85,86,87,88],"Hormone Replacement Therapy","Cardiovascular Diseases","Hormone Replacement Therapy, Post-Menopausal","Menopause",[90,91,92],"hormone replacement therapy","cardiovascular disease","menopause","NOT_YET_RECRUITING","2026-07-30",{"date":96,"type":97},"2026-07-31","ACTUAL",{"date":99,"type":81},"2026-08-01",{"date":101,"type":81},"2041-03",{"name":5,"class":6},2]