[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650775":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":31,"responsibleParty":54,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":10,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":78,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University Hospital, Antwerp","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Citrate group",null,"Patients needing continuous renal replacement therapy with absent or reduced citrate metabolism treated with regional citrate anticoagulation",[13],"Device: continuous renal replacement therapy with regional citrate anticoagulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","continuous renal replacement therapy with regional citrate anticoagulation","CVVHDF using regional citrate anticoagulation in patients with absent or reduced citrate metabolism",[9],[21,27],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"walter verbrugghe, MD","CONTACT","038214149","+32","Walter.Verbrugghe@uza.be",{"name":28,"role":23,"phone":29,"phoneExt":25,"email":30},"Rita Jacobs, MD","038214795","rita.jacobs2@uza.be",[32],{"facility":33,"status":10,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Antwerp University Hospital","Edegem","Antwerp","2650","Belgium","BE",{"type":40,"coordinates":41},"Point",[42,43],4.44504,51.15662,{"lat":43,"lon":42},[46,48,49,52],{"name":47,"role":23,"phone":24,"phoneExt":25,"email":26},"Walter Verbrugghe, MD",{"name":28,"role":23,"phone":29,"phoneExt":25,"email":30},{"name":50,"role":51,"phone":10,"phoneExt":10,"email":10},"Symen Ligthart, PhD","SUB_INVESTIGATOR",{"name":53,"role":51,"phone":10,"phoneExt":10,"email":10},"Philippe Jorens, PhD",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Walter Verbrugghe","MD","100650775","a-prospective-observational-study-to-evaluate-the-safety-and-feasibility-of-continuous-renal-replacement-therapy-with-regional-citrate-anticoagulation-in-a-cohort-critical-ill-patients-with-acute-kidney-injury-and-presumed-absent-citrate-metabolism-100650775",false,"NCT07751874","A Prospective, Observational Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism","CAT-RISK","Inclusion Criteria:\n\n* Need for renal replacement therapy in the ICU with any of the following criteria:\n* anticipation of severely impaired citrate metabolism (serum lactate ≥ 5 mmol\u002Fl in patients with shock or requirement of a dextrose drip to prevent hypoglycemia or spontaneous INR \\> 3 and\u002For requirement of fresh frozen plasma to maintain INR \\\u003C 3 in patients with cirrhosis or acute liver failure or acute on chronic liver failure)\n* development of citrate toxicity under CRRT with RCA due to worsening citrate metabolism\n\nExclusion Criteria:\n\n* Pregnancy\n* A known hypersensitivity to citrate compounds\n* Refusal of informed consent","ALL","18 Years",{"count":68,"type":69},50,"ESTIMATED","OBSERVATIONAL","Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.",[73],"Acute Kidney Injury",[75,76,77],"Acute kidney injury","Regional citrate anticoagulation","citrate metabolism","NOT_YET_RECRUITING","2026-08-03",{"date":81,"type":82},"2026-08-07","ACTUAL",{"date":84,"type":69},"2026-10-15",{"date":86,"type":69},"2028-07-01",{"name":5,"class":6},1]