[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654290":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":24,"studyPopulation":28,"armGroups":29,"interventions":24,"overallOfficials":24,"centralContacts":34,"locations":40,"responsibleParty":54,"collaborators":24,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":24,"enrollmentInfo":67,"targetDuration":24,"studyType":70,"phases":24,"briefSummary":71,"conditions":72,"keywords":24,"overallStatus":75,"whyStopped":24,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":24},[9],{"measure":10,"description":11,"timeFrame":12},"The association between intraoperative hypotension and postoperative delirium","Intraoperative hypotension was defined by absolute mean arterial pressure (MAP) thresholds (sustained MAP \\\u003C 75, 70, 65, or 60 mm Hg for \\> 1 min) or relative MAP reductions (10%, 20%, 30%, or 40% below preoperative baseline). The Confusion Assessment Method for the Intensive Care Unit scale (CAM-ICU) or 3 min diagnostic interview for CAM (3D-CAM) will be applied to assess postoperative delirium.","The surgery day and twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days.",[14,18,21],{"measure":15,"description":16,"timeFrame":17},"Characteristic of electroencephalogram","Electroencephalographic signals will be acquired with the Masimo SedLine® monitor, which will yield the Patient State Index (PSI), burst-suppression ratio, raw EEG traces, density spectral array, spectral edge frequency, and electromyographic data. Frequency bands will be predefined as delta (1-3 Hz), theta (4-7 Hz), alpha (8-12 Hz), and beta (13-40 Hz). Relative power for each band will be computed relative to total spectral power.","The surgery day",{"measure":19,"description":20,"timeFrame":17},"Regional cerebral oxygen saturation changes","Regional cerebral oxygen saturation will be monitored with near-infrared spectroscopy.",{"measure":22,"description":23,"timeFrame":17},"Blood inflammatory factors","Arterial blood (4 mL) will be collected from patients during surgery, and blood inflammatory factors will be measured.",null,{"allocation":24,"interventionModel":24,"interventionModelDescription":24,"primaryPurpose":24,"observationalModel":26,"timePerspective":27,"maskingInfo":24},"COHORT","PROSPECTIVE","The study population will be selected from elderly patients scheduled to undergo elective craniotomy for intracranial tumour resection at Beijing Tiantan Hospital.",[30,32],{"label":31,"type":24,"description":24,"interventionNames":24},"Intraoperative hypotension",{"label":33,"type":24,"description":24,"interventionNames":24},"Without intraoperative hypotension",[35],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Yuming Peng, M.D., Ph.D","CONTACT","8610-59976658","florapym766@163.com",[41],{"facility":42,"status":24,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":24},"Beijing Tian Tan Hospital, Capital Medical University","Beijing","Beijing Municipality","100070","China","CN",{"type":49,"coordinates":50},"Point",[51,52],116.39723,39.9075,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Yuming Peng","Deputy chief of Department of Anesthesiology","100654290","a-study-for-postoperative-delirium-in-older-patients-with-intracranial-tumors-100654290",false,"NCT07797660","A Study for Postoperative Delirium in Older Patients With Intracranial Tumors","A Study on Prevention and Treatment Mechanisms for Postoperative Delirium in Older Patients With Intracranial Tumors","Inclusion Criteria:\n\n* Patients undergoing elective craniotomy for intracranial tumour resection\n* Patients who will provide written informed consent\n\nExclusion Criteria:\n\n* Patients with severe preoperative cognitive impairment precluding subsequent assessments\n* History of psychotropic medication use\n* Previous history of neurosurgical operation\n* Severe bradycardia (heart rate \\\u003C 40 beats per minute)\n* Sick-sinus syndrome or atrioventricular block of grade Ⅱ or above\n* Severe hepatic insufficiency (Child-Pugh grade C)\n* Renal failure requiring renal replacement therapy","ALL","60 Years",{"count":68,"type":69},164,"ESTIMATED","OBSERVATIONAL","Postoperative delirium is a common acute central nervous system syndrome, which often occurs 1-5 days after surgery. Postoperative delirium can prolong the length of hospital stay, increase the mortality rate, and is also associated with long-term postoperative cognitive dysfunction. However, the pathogenesis of postoperative delirium in elderly patients undergoing neurosurgical procedures, who are at high risk for ostoperative delirium, remains unclear. This study aims to elucidate the underlying mechanisms of postoperative delirium in this population and inform the development of effective prevention and treatment strategies.",[73,74],"Delirium","Brain Tumor","NOT_YET_RECRUITING","2026-08-28",{"date":78,"type":79},"2026-09-01","ACTUAL",{"date":81,"type":69},"2026-08-30",{"date":83,"type":69},"2027-09-30",{"name":5,"class":6},1]