[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650390":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":22,"responsibleParty":36,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":10,"enrollmentInfo":48,"targetDuration":10,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":10,"overallStatus":25,"whyStopped":10,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},{"fullName":5,"class":6},"Janssen-Cilag Kft.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Moderate to Severe Psoriasis: Guselkumab Switching From Ustekinumab",null,"Participants with moderate-to-severe psoriasis who are candidates for systemic treatment (according to the guselkumab label) and who are medically indicated to switch from Ustekinumab or its biosimilar to receive Guselkumab in routine clinical practice will be enrolled. No drug will be provided as a part of this study. Only data available from routine clinical practice will be collected.",[13],{"name":14,"affiliation":5,"role":15},"Janssen-Cilag Kft. Clinical Trial","STUDY_DIRECTOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Study Contact","CONTACT","844-434-4210","Participate-In-This-Study1@its.jnj.com",[23],{"facility":24,"status":25,"city":26,"state":10,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":10},"Semmelweis University","RECRUITING","Budapest","1088","Hungary","HU",{"type":31,"coordinates":32},"Point",[33,34],19.04045,47.49835,{"lat":34,"lon":33},{"type":37,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100650390","a-study-of-guselkumab-given-after-ustekinumab-in-participants-with-moderate-to-severe-psoriasis-in-routine-clinical-practice-100650390",false,"NCT07746583","A Study of Guselkumab Given After Ustekinumab in Participants With Moderate to Severe Psoriasis in Routine Clinical Practice","A Non-Interventional, Multi-Centric, Single Country Observational Study to Assess the Safety and Effectiveness of Guselkumab After Ustekinumab (Originator or Biosimilar) in Moderate to Severe Psoriasis Patients in Clinical Routine","G-START","Inclusion criteria:\n\n* Must have a confirmed diagnosis of moderate-to-severe plaque psoriasis requiring systemic treatment\n* Participants who are currently being treated with Ustekinumab (either the originator or its biosimilar) and who are medically indicated to switch to Guselkumab, or for whom this switch is medically indicated, based on the current and valid national psoriasis (PsO) therapeutic protocol\n* Participants who, based on the Investigator's decision, should initiate treatment with Guselkumab\n* Participants must sign an informed consent form (ICF) allowing for data collection and source data verification in accordance with local requirements\n\nExclusion criteria:\n\n* Contraindication or hypersensitivity to Guselkumab or any other ingredient in the injection solution\n* Pregnancy or breastfeeding\n* Currently enrolled in an interventional study\n* Currently enrolled in an observational study sponsored or managed by a Janssen company\n* Previous use of guselkumab in any indication in participant history","ALL","18 Years",{"count":49,"type":50},100,"ESTIMATED","OBSERVATIONAL","The main purpose of this study is to describe how well Guselkumab works after switching from Ustekinumab in participants with moderate to severe psoriasis in a routine clinical setting. A long-term skin disease that causes red, scaly and sometimes painful, itchy patches on the skin.",[54],"Psoriasis","2026-08-04",{"date":57,"type":58},"2026-08-05","ACTUAL",{"date":60,"type":50},"2026-08-07",{"date":62,"type":50},"2029-02-07",{"name":5,"class":6},1]