[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612126":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":129,"collaborators":10,"id":131,"slug":132,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":10,"eligibilityCriteria":137,"healthyVolunteers":133,"sex":138,"minAge":139,"maxAge":10,"enrollmentInfo":140,"targetDuration":10,"studyType":143,"phases":10,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":159},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Participants diagnosed with non-Hodgkin lymphoma or multiple myeloma",null,"Participants must have pathologically confirmed Diagnosed with non-Hodgkin lymphoma or multiple myeloma.",[13],"Diagnostic Test: Audio Tasks",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Audio Tasks","Voice recordings will be collected at baseline (pre-infusion), twice daily from Day 0 through Day +10, and, if ICANS develops, twice daily until three days after clinical resolution. A final voice recording will also be performed on Day +30",[9],[21],{"name":22,"affiliation":5,"role":23},"Roni Shouval, MD, PhD","PRINCIPAL_INVESTIGATOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","646-888-3483","shouvalr@mskcc.org",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"Mohammad Alhomoud, MD","646-608-4375","alhomom@mskcc.org",[34,51,62,73,85,96,110,118],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)","RECRUITING","Basking Ridge","New Jersey","07920","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-74.54932,40.70621,{"lat":46,"lon":45},[49],{"name":50,"role":26,"phone":27,"phoneExt":10,"email":10},"Roni Shoulval, MD, PhD",{"facility":52,"status":36,"city":53,"state":38,"zip":54,"country":40,"countryCode":41,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Memorial Sloan Kettering Monmouth (Consent only)","Middletown","07748",{"type":43,"coordinates":56},[57,58],-74.11709,40.39428,{"lat":58,"lon":57},[61],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":10},{"facility":63,"status":36,"city":64,"state":38,"zip":65,"country":40,"countryCode":41,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Memorial Sloan Kettering Bergen (Consent Only)","Montvale","07645",{"type":43,"coordinates":67},[68,69],-74.02292,41.04676,{"lat":69,"lon":68},[72],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":10},{"facility":74,"status":36,"city":75,"state":76,"zip":77,"country":40,"countryCode":41,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)","Commack","New York","11725",{"type":43,"coordinates":79},[80,81],-73.29289,40.84288,{"lat":81,"lon":80},[84],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":10},{"facility":86,"status":36,"city":87,"state":76,"zip":88,"country":40,"countryCode":41,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Memorial Sloan Kettering Westchester (Consent only)","Harrison","10604",{"type":43,"coordinates":90},[91,92],-73.71263,40.96899,{"lat":92,"lon":91},[95],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":10},{"facility":97,"status":98,"city":76,"state":76,"zip":99,"country":40,"countryCode":41,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Weill Cornell Medical Center (Data Analysis Only)","NOT_YET_RECRUITING","10021",{"type":43,"coordinates":101},[102,103],-74.00597,40.71427,{"lat":103,"lon":102},[106],{"name":107,"role":26,"phone":108,"phoneExt":10,"email":109},"Alexandros Sigaras","(646) 962-5634","als2076@med.cornell.edu",{"facility":111,"status":36,"city":76,"state":76,"zip":112,"country":40,"countryCode":41,"cosmosGeoPoint":113,"geoPoint":115,"contacts":116},"Memorial Sloan Kettering Cancer Center (All Protocol Activites)","10065",{"type":43,"coordinates":114},[102,103],{"lat":103,"lon":102},[117],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":10},{"facility":119,"status":36,"city":120,"state":76,"zip":121,"country":40,"countryCode":41,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Memorial Sloan Kettering Nassau (Limited Protocol Activities)","Rockville Centre","11553",{"type":43,"coordinates":123},[124,125],-73.64124,40.65871,{"lat":125,"lon":124},[128],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":10},{"type":130,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100612126","a-study-of-voice-as-a-way-to-monitor-for-side-effects-in-people-receiving-car-t-cell-therapy-100612126",false,"NCT07249528","A Study of Voice as a Way to Monitor for Side Effects in People Receiving CAR T-Cell Therapy","Voice as a Digital Biomarker of Neurotoxicity in CAR T-Cell Therapy","Inclusion Criteria:\n\n* Documentation of Disease\n\n  o Patients must have pathologically confirmed Diagnosed with non-Hodgkin lymphoma or multiple myeloma.\n* Definition of treatment and ability\n\n  * Scheduled to receive an FDA-approved CAR-T product: Axi-cel, Liso-cel, Tisa-cel, Ide-cel, Cilta-cel, or Brexu-cel.\n  * Ability to comply with twice daily voice recordings or daily neurologic assessments, as determined by the investigator.\n* Age ≥ 18\n* ECOG Performance Status of ≤ 2\n* Required\n\n  * Perform twice daily voice recordings using a smartphone.\n  * Undergo daily neurologic assessments (e.g., ICE score, tremor evaluation).\n  * Smartphone ownership.\n  * Sufficient English proficiency to complete structured voice tasks in the study application.\n* Comorbid Conditions\n\n  * No pre-existing neurological conditions that significantly impair speech, including but not limited to severe dysarthria, expressive aphasia, or neurodegenerative disorders.\n  * No history of significant speech or voice disorders, including laryngeal paralysis, severe dysphonia, or recent vocal cord surgery or radiation to the area.\n  * No pathology affecting the vocal cords that could interfere with voice analysis, such as vocal cord paralysis, chronic laryngitis, vocal cord nodules, polyps, granulomas, or malignancies.\n  * No severe hearing impairment that would interfere with voice assessments\n* Language o Proficiency in spoken English is required, without the need for native-level fluency. This ensures participants can accurately perform structured voice tasks, as the application and underlying acoustic models are currently validated only in English, despite the limitation in generalizability. Participants with language barriers that prevent reliabletask completion or data interpretation will be excluded.","ALL","18 Years",{"count":141,"type":142},20,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to collect voice recordings and nervous system (neurologic) assessments from people with non-Hodgkin lymphoma (NHL) or multiple myeloma (MM) who are receiving standard treatment with CAR T-cell therapy. Researchers will study whether these voice recordings and assessments are a practical (feasible) way to monitor for immune effector cell-associated neurotoxicity syndrome (ICANS). Feasibility will be measured by tracking how many participants join the study and complete the assessments.",[146,147],"Non-hodgkin Lymphoma","Multiple Myeloma",[146,147,5,149],"25-317","2026-08-05",{"date":152,"type":153},"2026-08-06","ACTUAL",{"date":155,"type":153},"2026-04-17",{"date":157,"type":142},"2027-12",{"name":5,"class":6},8]