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Medical College & Hospital","Cuttack","753007",{"type":74,"coordinates":1254},[1255,1256],85.87927,20.46497,{"lat":1256,"lon":1255},[1259],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1261,"status":67,"city":1262,"state":53,"zip":1263,"country":1220,"countryCode":1221,"cosmosGeoPoint":1264,"geoPoint":1268,"contacts":1269},"Osmania Medical College & Hospital","Hyderabad, Afzalgunj","500012",{"type":74,"coordinates":1265},[1266,1267],78.45636,17.38405,{"lat":1267,"lon":1266},[1270],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1272,"status":67,"city":1273,"state":53,"zip":1274,"country":1220,"countryCode":1221,"cosmosGeoPoint":1275,"geoPoint":1279,"contacts":1280},"Shree Mahalaxmi Diatone Institute","Kolhāpur","416003",{"type":74,"coordinates":1276},[1277,1278],74.23167,16.69563,{"lat":1278,"lon":1277},[1281],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1283,"status":67,"city":1284,"state":53,"zip":1285,"country":1220,"countryCode":1221,"cosmosGeoPoint":1286,"geoPoint":1290,"contacts":1291},"Sanjay Gandhi Post Graduate Institute of Medical Sciences","Lucknow","226 014",{"type":74,"coordinates":1287},[1288,1289],80.92313,26.83928,{"lat":1289,"lon":1288},[1292],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1294,"status":67,"city":1295,"state":53,"zip":1296,"country":1220,"countryCode":1221,"cosmosGeoPoint":1297,"geoPoint":1301,"contacts":1302},"Diabetes Care and Research 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Delhi","110029",{"type":74,"coordinates":1320},[1321,1322],77.2148,28.62137,{"lat":1322,"lon":1321},[1325],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1327,"status":67,"city":1328,"state":53,"zip":1329,"country":1220,"countryCode":1221,"cosmosGeoPoint":1330,"geoPoint":1334,"contacts":1335},"Deenanath Mangeshkar Hospital and Research Centre","Pune","411004",{"type":74,"coordinates":1331},[1332,1333],73.85535,18.51957,{"lat":1333,"lon":1332},[1336],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1338,"status":67,"city":1339,"state":53,"zip":1340,"country":1220,"countryCode":1221,"cosmosGeoPoint":1341,"geoPoint":1345,"contacts":1346},"Jothydev's Diabetes Research Centre","Trivandrum","695032",{"type":74,"coordinates":1342},[1343,1344],76.94924,8.4855,{"lat":1344,"lon":1343},[1347],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1349,"status":67,"city":1350,"state":53,"zip":1351,"country":1220,"countryCode":1221,"cosmosGeoPoint":1352,"geoPoint":1356,"contacts":1357},"Vishakha Institute of Medical Sciences","Visakhapatnam","530040",{"type":74,"coordinates":1353},[1354,1355],83.20161,17.68009,{"lat":1355,"lon":1354},[1358],{"name":5,"role":61,"phone":1229,"phoneExt":53,"email":1230},{"facility":1360,"status":67,"city":1361,"state":1362,"zip":1363,"country":1364,"countryCode":1365,"cosmosGeoPoint":53,"geoPoint":53,"contacts":1366},"New Zealand Clinical Research (NZCR) Christchurch","Christchurch Central City","Christchurch","8011","New Zealand","NZ",[1367],{"name":5,"role":61,"phone":1368,"phoneExt":53,"email":1369},"0800440725","newzealand@bitrialsupport.com",{"facility":1371,"status":67,"city":1372,"state":1373,"zip":1374,"country":1364,"countryCode":1365,"cosmosGeoPoint":53,"geoPoint":53,"contacts":1375},"Momentum Clinical Research Dunedin","Central Dunedin","Dunedin","9016",[1376],{"name":5,"role":61,"phone":1368,"phoneExt":53,"email":1369},{"facility":1378,"status":67,"city":1379,"state":53,"zip":1380,"country":1364,"countryCode":1365,"cosmosGeoPoint":1381,"geoPoint":1385,"contacts":1386},"Waitemata Clinical Research","Auckland","0626",{"type":74,"coordinates":1382},[1383,1384],174.76349,-36.84853,{"lat":1384,"lon":1383},[1387],{"name":5,"role":61,"phone":1368,"phoneExt":53,"email":1369},{"facility":1389,"status":67,"city":1390,"state":53,"zip":1391,"country":1364,"countryCode":1365,"cosmosGeoPoint":1392,"geoPoint":1396,"contacts":1397},"Clinical Trials New Zealand Ltd","Hamilton","3204",{"type":74,"coordinates":1393},[1394,1395],175.28333,-37.78333,{"lat":1395,"lon":1394},[1398],{"name":5,"role":61,"phone":1368,"phoneExt":53,"email":1369},{"facility":1400,"status":67,"city":1401,"state":53,"zip":1402,"country":1403,"countryCode":1404,"cosmosGeoPoint":1405,"geoPoint":1409,"contacts":1410},"Isis Clinical Research Center","Guaynabo","00968","Puerto Rico","PR",{"type":74,"coordinates":1406},[1407,1408],-66.111,18.35745,{"lat":1408,"lon":1407},[1411],{"name":5,"role":61,"phone":1412,"phoneExt":53,"email":82},"18336022368",{"type":1414,"investigatorFullName":53,"investigatorTitle":53,"investigatorAffiliation":53,"oldNameTitle":53,"oldOrganization":53},"SPONSOR","100651033","a-study-to-test-whether-survodutide-helps-people-with-type-2-diabetes-control-their-blood-sugar-100651033",false,"NCT07754461","A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar","A Phase III, Randomised, Double-blind, Parallel-group, 56-week Study, Evaluating the Efficacy and Safety of Survodutide (BI 456906), Compared With Placebo, in Participants With Type 2 Diabetes, as an Adjunct to Diet and Physical Activity Alone or in Combination With Either Oral Antidiabetic Medications or Insulin","Inclusion criteria:\n\n1. Male or female, age ≥18 years at the time of signing informed consent, and at least the legal age of consent in countries where it is \\>18 years\n2. Diagnosed with type 2 diabetes mellitus (T2D) (e.g. American diabetes association (ADA)\u002FEuropean association for the study of diabetes (EASD) guidelines) and must meet requirements for one of background therapy parts A, B or C:\n\n   1. Part A: Naïve to insulin therapy and have not used oral or injectable anti-hyperglycaemic (diabetes) medication for at least 90 days prior to screening (Visit 1) and glycosylated haemoglobin A1c (HbA1c) ≥7.0 (≥53 mmol\u002Fmol) and \\\u003C9.5% (\\\u003C80 mmol\u002Fmol) as measured by the central laboratory at screening (Visit 1);\n   2. Part B: Treated with stable dose of oral antidiabetic medication (OAD) for 90 days prior to screening (Visit 1) as monotherapy or combination of: Maximum tolerated dose of metformin and\u002For Maximum tolerated dose of sulfonylurea and\u002For Maximum tolerated dose of sodium-glucose cotransporter 2 inhibitor (SGLT2i) and HbA1c ≥7.0% (≥53 mmol\u002Fmol) and \\\u003C10.5% (\\\u003C91 mmol\u002Fmol) as measured by the central laboratory at screening (Visit 1);\n   3. Part C: Stable use of basal insulin at a dose of ≥20 international units (IU)\u002Fday with or without stable dose of metformin and\u002For SGLT2i for 90 days prior to screening (Visit 1) and HbA1c ≥7.0% (≥53 mmol\u002Fmol) and \\\u003C10.5% (\\\u003C91 mmol\u002Fmol) as measured by the central laboratory at screening (Visit 1)\n3. Body mass index (BMI) ≥23 kg\u002Fm2 at screening (Visit 1)\n4. Signed and dated written informed consent in accordance with international council for harmonisation - good clinical practice (ICH-GCP) and local legislation prior to admission to the trial\n5. Woman (or women) of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per international council for harmonisation of technical requirements for pharmaceuticals for human use M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly.\n6. In the investigator's opinion, participants are well-motivated, capable, and willing to: Learn how to self-inject the investigational medicinal product (IMP), as required for this protocol (persons with physical limitations who are not able to perform the injections must have the assistance of an individual trained to inject the IMP); Inject the IMP or accept injection from a designated person; Follow study procedures for the duration of the study, including, but not limited to: follow lifestyle advice (for example, dietary restrictions and exercise plan), maintain a diary, complete required questionnaires, and handle the IMP as described in the instructions for use (IFU)\n\nExclusion criteria:\n\n1. Type 1 diabetes mellitus (T1D) or latent autoimmune diabetes in adults (LADA)\n2. Treatment within 90 days before screening (Visit 1) up to and including randomisation (Visit 2) with any: glucagon-like peptide-1 receptor (GLP-1R) agonists including GLP-1R agonist\u002Fglucose-dependent insulinotropic polypeptide (GIP) combinations, amylin or incretin combinations; Glucose-lowering drugs other than stated in the inclusion criteria for each part (i.e. metformin, Sodium-Glucose Cotransporter 2 Inhibitor (SGLT2i), basal insulin, depending on the background therapy part); Glucose-lowering investigational drug; Any anti-obesity medication including bupropion\u002Fnaltrexone, orlistat, phentermine, and phentermine\u002Ftopiramate\n3. History of ketoacidosis or hyperosmolar state or coma within the last 6 months before screening (Visit 1) up to and including randomisation (Visit 2)\n4. Hypoglycaemia unawareness or a history of severe hypoglycaemia within the last 3 months before screening (Visit 1) up to and including randomisation (Visit 2)\n5. Diabetic retinopathy or maculopathy currently under treatment, or that is reasonably anticipated to require such treatment over the duration of the study\n6. Body weight change (self-reported) \\>5% within 90 days before screening (Visit 1)\n7. Previous or planned (during the trial period) treatment for obesity with surgery or a weight loss device, including any prior bariatric surgery. The following are allowed: (1) liposuction and\u002For abdominoplasty, if performed \\>1 year before screening (Visit 1), (2) lap banding, if the band has been removed \\>1 year before screening (Visit 1), (3) intragastric balloon, if the balloon has been removed \\>1 year before screening (Visit 1), (4) duodenal-jejunal bypass sleeve, if the sleeve has been removed \\>1 year before screening (Visit 1).\n8. Answered \"yes\" to any of the suicide-related behaviours (Actual attempt, Interrupted attempt, Aborted attempt, Preparatory act or behaviour) or to the non-suicidal self-injurious behaviour question on the \"Suicidal Behaviour\" section of the Columbia-Suicide Severity Rating Scale (C-SSRS) related to the past 2 years before screening (Visit 1) up to and including randomisation (Visit 2)\n9. Further exclusion criteria apply.","ALL","18 Years",{"count":1425,"type":1426},600,"ESTIMATED","INTERVENTIONAL",[1429],"PHASE3","This study aims to find out whether a study medicine called survodutide helps people control their blood sugar. Adults who live with type 2 diabetes and with a body mass index (BMI) of 23 kg\u002Fm2 or higher can join.\n\nThe study has 3 parts. In each part the study compares survodutide with placebo. Survodutide is being developed to treat several health problems including type 2 diabetes. Placebo looks like survodutide but does not contain any medicine.\n\nDepending on a person's diabetes treatment, a person will be assigned either to\n\n* Part A: healthy eating and physical activity\n* Part B: diabetes tablets (no injection of insulin)\n* Part C: injection of insulin (with or without diabetes tablets)\n\nParticipants are randomly put into 1 of 3 groups, which means the group is chosen by chance. Two groups of participants get survodutide at different dose levels, and the third group gets placebo as injection under the skin once a week. You have a 2 in 3 chance of getting survodutide. During the study, participants continue their regular diabetes treatment.\n\nParticipants are in the study for about 1 year and 2 months. During this time, they attend up to 12 visits at the site and receive at least 9 phone calls. Study doctors regularly test participants' blood sugar by checking their HbA1c values and other laboratory test results. The study doctor also regularly checks participants' health and takes note of any changes. For each study part, the results will be compared between the survodutide and the placebo group to see whether the treatment works.",[1432],"Type 2 Diabetes","2026-08-20",{"date":1435,"type":1436},"2026-08-21","ACTUAL",{"date":1438,"type":1426},"2026-08-24",{"date":1440,"type":1426},"2028-05-01",{"name":5,"class":6},120]