[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647190":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":42,"centralContacts":46,"locations":12,"responsibleParty":56,"collaborators":12,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":12,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":88,"whyStopped":12,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":12},{"fullName":5,"class":6},"Poznan University of Physical Education","OTHER",[8,13,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","NO_INTERVENTION","The healthy, control group (n = 70) will be included in the study. Assessments will be conducted at three time points. Participants will be instructed not to modify their usual lifestyle throughout the study period.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"IWT- Interval Walking Training","EXPERIMENTAL","The healthy IWT group- a six-month supervised exercise intervention conducted under the supervision of a qualified exercise trainer.",[18],"Other: Experimental: IWT- Interval Walking Training",{"label":20,"type":15,"description":21,"interventionNames":22},"HICT-High Intensity Circuit Training","The healthy HICT group - a six-month supervised exercise intervention conducted under the supervision of a qualified exercise trainer.",[23],"Other: Exercise training II",{"label":25,"type":15,"description":26,"interventionNames":27},"Onco-female group","A group of female cancer survivors will be included in the study. Participants will be encouraged to achieve a moderate level of physical activity equivalent to approximately 8,000 steps per day. Physical activity will be continuously monitored using wearable step-counting devices, and compliance with the prescribed activity will be regularly supervised by a physiotherapist.",[28],"Other: Walking",[30,34,38],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":12},"Experimental: IWT- Interval Walking Training","Interval Walking Training will consist of five repetitions of alternating 3-minute intervals of fast and slow walking, resulting in a total exercise duration of 30 minutes per session. The training period will last 6 months, two training session\u002Fa week.",[14],{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":12},"Exercise training II","HICT training will consist of ten exercises: jumping jacks, push-ups, abdominal crunches, squats, planks, triceps dips using a chair, high knees (running in place), lunges, push-ups with rotation, and side planks. Each exercise will be performed for 30 seconds, followed by a 10-second transition period. A 2-minute rest period will be provided between sets. Training period will last 6 monts \u002Fa two training session a week",[20],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":12},"Walking","Walking training is addressed to breast cancer patients who have already finished onco-treatment. Participants will be instructed to maintain a daily step count of 7,000-10,000 steps throughout the study period.",[25],[43],{"name":44,"affiliation":5,"role":45},"Urszula Czerniak, PhD","PRINCIPAL_INVESTIGATOR",[47,52],{"name":48,"role":49,"phone":50,"phoneExt":12,"email":51},"Marzena Szerment, MA","CONTACT","0048618355061","marzena.szerment@awf.poznan.pl",{"name":53,"role":49,"phone":54,"phoneExt":12,"email":55},"Ewa Ziemann, Professor","0048606330944","ewa.ziemann@awf.poznan.pl",{"type":57,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100647190","a-two-way-path-to-health-environmental-influences-on-skeletal-muscle-endocrine-function-100647190",false,"NCT07706465","A Two-Way Path to Health: Environmental Influences on Skeletal Muscle Endocrine Function","A Two-Way Path to Health: Exploring Whether Environmental Factors Influence Skeletal Muscle Endocrine Function and Modulate Physical Activity-Induced Adaptations in Middle-Aged Women","COMPASS","Inclusion Criteria (HICT, IWT and Control groups):\n\n* Women,\n* aged 35-75 years\n* qualified by a physician for participation in the study and with no contraindications to the training intervention (e.g., heart failure, asthma, chronic obstructive pulmonary disease \\[COPD\\], or arthritis)\n\nInclusion Criteria (Onco Group):\n\n* Women ,\n* aged 35-75 years,\n* Diagnosed with invasive breast cancer, Stage I-III disease according to the TNM classification,\n* Estrogen receptor-positive (ER+) breast cancer, defined as expression in at least 10% of tumor cell nuclei,\n* Adjuvant hormone therapy with an aromatase inhibitor for at least 6 months,\n* BMI between 18.5 and 32 kg\u002Fm².\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.\n* No chronic diseases limiting the possibility of oncological treatment.\n* No contraindications to daily physical activity.\n* Willingness to maintain a daily step count of 8,000 steps.\n\nExclusion Criteria (HICT, IWT and Control groups):\n\n* history of cardiovascular disease,\n* previous hospitalization for cardiovascular conditions,\n* ongoing cardiovascular treatment, or recent cardiovascular symptoms,\n* advanced osteoporosis\n\nExclusion Criteria (Onco Group):\n\n* Stage IV invasive breast cancer according to the TNM classification.\n* ECOG performance status ≥2.\n* Unstable ischemic heart disease.\n* Cardiac arrhythmias.\n* Advanced degenerative joint disease.\n* Rheumatic disorders (including rheumatoid arthritis, osteoarthritis, or fibromyalgia).\n* Progression of chronic diseases.\n* Pregnancy.\n* BMI \\\u003C18.5 or \\>32 kg\u002Fm².\n* Uncontrolled hypothyroidism or hyperthyroidism.",true,"FEMALE","35 Years","75 Years",{"count":71,"type":72},300,"ESTIMATED","INTERVENTIONAL",[75],"NA","Given the well-established anti-inflammatory and health-promoting effects of physical activity as a non-pharmacological intervention, an important question remains whether different types of exercise differ in their ability to reduce the body burden of per- and polyfluoroalkyl substances (PFAS) and whether PFAS exposure modifies exercise-induced adaptive responses. The investigators hypothesize that the coexistence of physical inactivity, overweight\u002Fobesity, reduced muscle mass, and consequently lower concentrations of myokines\u002Fexerkines contributes to impaired cardiovascular function, reduced exercise capacity, and a greater PFAS body burden. Collectively, these factors may adversely affect work ability, reduce occupational participation, and discourage continued employment among middle-aged women. In the context of unfavorable demographic trends, such consequences may represent a significant economic burden for society.\n\nThe primary objective of this project is to determine whether baseline PFAS concentrations are associated with the health status of women entering the study and to characterize circulating profiles of myokines\u002Fexerkines and arginine metabolites. A secondary objective is to compare the effects of different exercise programs on PFAS concentrations and their potential elimination from the body. In addition, we will investigate whether a history of cancer treatment, despite increasingly favorable clinical outcomes, is associated with long-term alterations in skeletal muscle endocrine function, myokine and exerkine release, and PFAS body burden.\n\nThe study will include perimenopausal women. Participants will be allocated to one of two supervised exercise programs: high-intensity circuit training (HICT) or interval walking training (IWT). Both interventions will last six months and will be performed two times per week (with possible additional unit performed at home). This period will be followed by six months of unsupervised maintenance training. Two additional groups will be included: a control group maintaining their usual lifestyle and a group of women who have completed cancer treatment. Participants in the oncology group will be instructed to maintain a daily physical activity level of approximately 7,000-10,000 steps.\n\nAssessments will be performed at baseline, immediately after the intervention, and six months after its completion. Circulating concentrations of selected myokines, exerkines, arginine metabolites, and 18 PFAS compounds will be measured in blood, while PFAS concentrations will also be determined in urine samples. Cardiorespiratory fitness, body composition assessed by dual-energy X-ray absorptiometry (DXA), dietary habits, quality of life, and health literacy will also be evaluated.",[78,79],"Healthly Volunteers","Oncologic Disease",[81,82,83,84,85,86,87],"PFAS","skeletal muscle endocrine function","myokines and exerkines","physical activity","perimenopausal women","exercise adaptation","women's health","NOT_YET_RECRUITING","2026-07-13",{"date":91,"type":92},"2026-07-15","ACTUAL",{"date":94,"type":72},"2026-08-20",{"date":96,"type":72},"2029-01-30",{"name":5,"class":6}]