[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645545":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":10,"responsibleParty":30,"collaborators":34,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":10,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":10,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"Esbjerg Hospital - University Hospital of Southern Denmark","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bariatric surgery and subsequently cholecystectomy for gallstone disease",null,"The case group. 135 patients.",[13],"Diagnostic Test: blood sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"Bariatric surgery and no gallstone disease","Control group. A minimum of 5 years of follow up after bariatric surgery.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","blood sampling","Targeted genetic analysis of the ABCG8 D19H variant and the UGT1A1 rs6742078 variant using a blood sample.",[15,9],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Benjamin Petersen, M.D","CONTACT","+45 7918 5714","benjamin.drejer.petersen@rsyd.dk",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Benjamin Drejer Petersen","M.D., PhD Fellow",[35,37],{"name":36,"class":6},"Odense University Hospital",{"name":38,"class":6},"University of Southern Denmark","100645545","abcg8-ugt1a1-and-gallstone-disease-after-bariatric-surgery-100645545",false,"NCT07702630","ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery","ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery: A Genetic Study","Inclusion Criteria:\n\n* Bariatric surgery\n\nExclusion Criteria:\n\n* Gallstone disease or cholecystectomy prior to bariatric surgery",true,"ALL","18 Years",{"count":50,"type":51},270,"ESTIMATED","OBSERVATIONAL","The goal of this observational genetic case-control study is to learn whether two specific genetic variants in ABCG8 and UGT1A1 are associated with gallstone disease after bariatric surgery. The study includes adults who have previously undergone bariatric surgery.\n\nThe main questions it aims to answer are whether the ABCG8 D19H variant and the UGT1A1 rs6742078 variant are associated with an increased risk of gallstone disease requiring cholecystectomy after bariatric surgery.\n\nResearchers will compare patients who underwent bariatric surgery and later had their gallbladder removed because of gallstone disease with patients who underwent bariatric surgery but did not develop gallstone disease or undergo cholecystectomy during follow-up.\n\nParticipants will provide one blood sample for targeted genetic analysis and complete questionnaires about health, previous surgery, medication use, family history, and gastrointestinal quality of life. Relevant clinical information will also be collected from medical records.",[55,56,57,58,59],"Gallstone Disease","Bariatric Surgery","Metabolic Surgery","Cholecystectomy","Genetics","NOT_YET_RECRUITING","2026-07-16",{"date":63,"type":64},"2026-07-17","ACTUAL",{"date":66,"type":51},"2026-10-01",{"date":68,"type":51},"2029-03-01",{"name":5,"class":6}]