[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100657718":3},{"organization":4,"outcomesModule":7,"designInfo":30,"detailedDescription":29,"studyPopulation":29,"armGroups":38,"interventions":57,"overallOfficials":29,"centralContacts":71,"locations":29,"responsibleParty":81,"collaborators":29,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":29,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":29,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":106,"whyStopped":29,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":29},{"fullName":5,"class":6},"Kafrelsheikh University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":29},[9,13],{"measure":10,"description":11,"timeFrame":12},"Clinical attachment level","Clinical attachment level (CAL) will be measured in millimeters using UNC-15 periodontal probe from cementoenamel junction (CEJ) to the base of the pocket at baseline, 1, 3, and 6 months post-treatment.","Baseline, 1,3, and 6 months",{"measure":14,"description":15,"timeFrame":16},"Tumor necrosis factor alpha (TNF-alpha)","Tumor necrosis factor alpha levels in gingival crevicular fluid will be measured pg\u002Fml using enzyme-linked immunosorbent assay (ELISA)","Baseline, 1, and 3 months.",[18,22,26],{"measure":19,"description":20,"timeFrame":21},"Probing pocket depth (PPD)","Probing pocket depth (PPD) will be measured in millimeters using UNC-15 periodontal probe assessed at baseline, 1, 3, and 6 months.","Baseline, 1, 3, and 6 months",{"measure":23,"description":24,"timeFrame":25},"Gingival index (GI)","Gingival index (GI) will be assessed using the Silness and Löe Gingival Index at baseline 1, 3, and 6 months post-treatment","Baseline, 1, 3, and 6 months.",{"measure":27,"description":28,"timeFrame":25},"Plaque index (PI)","Plaque index will be assessed using the Silness and Löe plaque index at baseline, 1, 3, and 6 months post-treatment.",null,{"allocation":31,"interventionModel":32,"interventionModelDescription":29,"primaryPurpose":33,"observationalModel":29,"timePerspective":29,"maskingInfo":34},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":35,"maskingDescription":29,"whoMasked":36},"SINGLE",[37],"PARTICIPANT",[39,45,51],{"label":40,"type":41,"description":42,"interventionNames":43},"Group A - SRP plus placebo gel","PLACEBO_COMPARATOR","Scaling and root planing followed by locally delivered placebo gel ( Methyl Cellulose Gel)",[44],"Drug: Placebo gel (Methyle cellulose)",{"label":46,"type":47,"description":48,"interventionNames":49},"Group B - SRP plus Active oxygen gel","EXPERIMENTAL","Scaling and root planing followed by locally delivered active oxygen gel",[50],"Drug: Active oxygen gel",{"label":52,"type":53,"description":54,"interventionNames":55},"Group C - SRP plus chlorhexidine gel","ACTIVE_COMPARATOR","Scaling and root planing followed by locally delivered chlorhexidine gel",[56],"Drug: Chlorhexidine gel",[58,63,67],{"type":59,"name":60,"description":61,"armGroupLabels":62,"otherNames":29},"DRUG","Placebo gel (Methyle cellulose)","Methyle cellulose placebo gel administered subgingivally as adjunct to scaling and root planing",[40],{"type":59,"name":64,"description":65,"armGroupLabels":66,"otherNames":29},"Active oxygen gel","active oxygen gel administered subgingivally as adjunct to scaling and root planing",[46],{"type":59,"name":68,"description":69,"armGroupLabels":70,"otherNames":29},"Chlorhexidine gel","Chlorhexidine gel administered subgingivaly as adjunct to scaling and root planing",[52],[72,77],{"name":73,"role":74,"phone":75,"phoneExt":29,"email":76},"Sara Malik","CONTACT","+201505610567","Sara_pg03@den.kfs.edu.eg",{"name":78,"role":74,"phone":79,"phoneExt":29,"email":80},"Enas Elgendy","+20473109548","enas_ahmed@den.kfs.edu.eg",{"type":82,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Sara Adam Abdalla Malik","Postgraduate Researcher, Department of Periodontology, Faculty of Dentistry, Kafrelsheikh University","100657718","active-oxygen-gel-vs-chlorhexidine-gel-in-stage-ii-grade-b-periodontitis-100657718",false,"NCT07840716","Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B Periodontitis","Comparative Efficacy of Active Oxygen Gel Versus Chlorhexidine Gel as an Adjunct to Subgingival Instrumentation in the Treatment of Stage II Grade B Periodontitis: A Randomized Controlled Clinical Trial With Biomarkers Assessment.","Inclusion Criteria:\n\n* Adults aged 18-50 years.\n* Patients with stage II grade B periodontitis\n* Probing pocket. Depth less or equal to 5mm, CAL = 3 to 4mm in selected sites.\n* Good general health without systemic conditions affecting periodontal health.\n\nExclusion Criteria:\n\n* Smoking.\n* Pregnancy or lactating.\n* Allergy to chlorhexidine.\n* Patients under antibiotics or anti-inflammatory drugs within the past 3 months.\n* Previous periodontal therapy within the past 6 months.","ALL","18 Years","50 Years",{"count":96,"type":97},60,"ESTIMATED","INTERVENTIONAL",[100],"NA","This randomized controlled clinical trial will evaluate the effectiveness of locally delivered active oxygen gel and chlorhexidine gel as adjuncts to scaling and root planing in the treatment of stage II grade B periodontitis.Sixty participants will be randomly assigned to one of three parallel groups: SRP with placebo gel, SRP with active oxygen gel, or SRP with chlorhexidine gel. The study will evaluate changes in probing pocket depth, clinical attachment level, gingival index, plaque index, and gingival crevicular fluid tumor necrosis factor alpha levels at baseline and follow-up visits to compare the effects of the three treatment approaches.",[103],"Stage II Grade B Periodontitis",[105],"Periodontitis, Active oxygen gel, Chlorhexidine gel, Scaling and root planing, Gingival crevicular fluid, Local drug delivery, TNF-alpha.","NOT_YET_RECRUITING","2026-09-19",{"date":109,"type":110},"2026-09-25","ACTUAL",{"date":112,"type":97},"2026-09-30",{"date":114,"type":97},"2027-08",{"name":5,"class":6}]