[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652942":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":33,"locations":39,"responsibleParty":55,"collaborators":11,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":11,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":11,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":83,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Comfy Acupressure for the Elderly (CAE)","EXPERIMENTAL",null,[13],"Procedure: Comfy Acupressure for the Elderly",{"label":15,"type":16,"description":11,"interventionNames":17},"Least acupressure control (LAC)","SHAM_COMPARATOR",[18],"Procedure: Least acupressure control",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Comfy Acupressure for the Elderly","CAE consists of 12 steps, which need about 15 minutes to complete and concentrate on the acupoints on the face, head, neck, shoulder, and hand. CAE intervention will be conducted 3 times per week for 12 consecutive months by trained research assistants.",[9],[26],"CAE",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Least acupressure control","LAC consists of three acupoints in the head, neck\u002Fshoulder, and hand: Tongtian (BL7), Jianzhen (SI9), and Shousanli (LI10). The completion of one LAC session needs about 3 to 4 minutes. LAC intervention will be conducted 3 times per week for 12 consecutive months by trained research assistants.",[15],[32],"LAC",[34],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Zhang-Jin Zhang, PhD","CONTACT","(852) 39176445","zhangzj@hku.hk",[40],{"facility":41,"status":11,"city":42,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"School of Chinese Medicine, University of Hong Kong","Hong Kong","HK",{"type":45,"coordinates":46},"Point",[47,48],114.17469,22.27832,{"lat":48,"lon":47},[51],{"name":52,"role":36,"phone":53,"phoneExt":11,"email":54},"Mr. Fung","(852) 3917 6498","mailchinmed@hku.hk",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Prof. Zhang Zhang-Jin","Director and Professor","100652942","acupressure-as-long-term-intervention-to-slow-the-progression-of-earlymild-alzheimers-disease-100652942",false,"NCT07779863","Acupressure as Long-term Intervention to Slow the Progression of Early\u002FMild Alzheimer's Disease","Caregiver-administered Acupressure as Long-term Intervention to Slow the Progression of Early\u002FMild Alzheimer's Disease With Blood Amyloid and Tau Biomarkers: a Randomized Controlled Trial","Inclusion Criteria:\n\n* have at least one of the following abnormal plasma amyloid and tau levels: Aβ42\u002FAβ40 ratio ≤ 0.17, p-tau217 \\> 0.15 pg\u002Fml, or\u002Fand p-tau181 \\> 3.3 pg\u002Fml\n* have mild neurocognitive disorder with the Montreal Cognitive Assessment, Hong Kong version (HK-MoCA) in classifying mild neurocognitive disorder, in which mild neurocognitive disorder is defined as those whose HK-MoCA score falls between the 16th and 2nd percentile of his\u002Fher peers adjusted for age and education\n\nExclusion Criteria:\n\n* show moderate-to-severe dementia, as evidenced by a HK-MoCA score falling below the 2nd percentile of his\u002Fher peers adjusted for age and education\n* cannot proficiently communicate due to language function impairment\n* have severe skin lesions on acupressure areas\n* had a surgery on the head or neck\n* have a medical condition that is a contraindication for acupressure.","ALL","60 Years","85 Years",{"count":70,"type":71},188,"ESTIMATED","INTERVENTIONAL",[74],"NA","This is an assessor-blinded, randomized controlled trial. A total of 188 older adults aged 60-85 years with early\u002Fmild AD will be recruited from care and attention homes for the elderly and elderly activity centres. They will be randomly assigned to receive least acupressure control (LAC) (n = 94) and CAE (n = 94), administered by caregivers (i.e., trained research assistants), for 3 sessions a week for 12 months. The primary outcome is the change in the MoCA score from baseline. The secondary outcomes include functional independence, psychological well-being, sleep quality, and health-related quality of life. The outcomes will be assessed at baseline and once bimonthly thereafter, totalling 7 sessions. A linear mixed-effect model will be applied to compare the primary and secondary outcomes. Three blood samples will be collected at baseline, 6 months, and 12 months, respectively, and the baseline blood sample will be immediately measured for the measurement of plasma Aβ42, Aβ40, p-tau181, and p-tau217, GFAP, and NfL. Repeated two-way variance (ANOVA) will be used to detect significant differences in blood biomarkers between the two groups. Linear regression will be conducted to examine inter-correlations between clinical outcomes and biomarker levels. Health and social care resource use will additionally be recorded at baseline, 6 months, and 12 months for the economic evaluation to examine the cost-effectiveness of the CAE intervention compared with LAC.",[77],"Alzheimer's Disease",[79,80,81,82],"Alzheimer's disease","Acupressure","Dementia","Amyloid and tau biomarkers","NOT_YET_RECRUITING","2026-08-18",{"date":86,"type":87},"2026-08-21","ACTUAL",{"date":89,"type":71},"2027-01-01",{"date":91,"type":71},"2030-08-31",{"name":5,"class":6},1]