[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650860":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":25,"responsibleParty":45,"collaborators":48,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":77,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Central Hospital, Nancy, France","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Ultra-Endurance Runners",null,"Adult amateur runners participating in ultra-trail races (80 km or 160 km) undergoing prospective echocardiographic and biological assessments to evaluate acute cardiovascular adaptations to ultra-endurance exercise.",[13],{"name":14,"affiliation":15,"role":16},"Nathalie Pace, MD","CHRU de Nancy","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+33383157352","n.pace@chru-nancy.fr",{"name":23,"role":19,"phone":10,"phoneExt":10,"email":24},"Ninon Mougel, MD","n.mougel@chru-nancy.fr",[26],{"facility":27,"status":10,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Centre Hospitalier Régional Universitaire de Nancy","Vandœuvre-lès-Nancy","Meurthe-et-Moselle","54511","France","FR",{"type":34,"coordinates":35},"Point",[36,37],6.17114,48.66115,{"lat":37,"lon":36},[40,41,42,43],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},{"name":23,"role":19,"phone":10,"phoneExt":10,"email":24},{"name":14,"role":16,"phone":10,"phoneExt":10,"email":10},{"name":23,"role":44,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":16,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PACE Nathalie","MD, Cardiologist, Principal Investigator",[49],{"name":50,"class":51},"Association PACElab","UNKNOWN","100650860","acute-cardiac-effects-of-ultra-trail-running-100650860",false,"NCT07753694","Acute Cardiac Effects of Ultra-Trail Running","Echocardiographic Assessment of the Acute Impact of an Ultra-Trail Race on Cardiac Function","ULTRA-ECHO","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Registered participants in the \"Trail des Échos\" ultra-trail race (80 km or 160 km)\n* Valid health clearance according to French Athletics Federation requirements\n* Affiliation with a national health insurance system\n* Able to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known or suspected cardiovascular disease at screening, including coronary artery disease, heart failure, clinically significant arrhythmias, moderate-to-severe valvular disease, uncontrolled hypertension, or prior stroke\n* Acute infection or unstable chronic medical condition (e.g., uncontrolled diabetes, renal, hepatic, respiratory, thyroid, or inflammatory disease)\n* Current treatments that may interfere with cardiovascular or biological assessments (including renin-angiotensin-aldosterone system blockers, chronic diuretics, anticoagulants, or systemic corticosteroids)\n* Use of systemic non-steroidal anti-inflammatory drugs within 3 days before the race or planned during the event\n* Participation in another ultra-endurance race (≥80 km) within 7 days before or after the study race\n* Pregnancy or breastfeeding\n* Inability to provide informed consent or legal protection status\n* Participation in another interventional clinical study",true,"ALL","18 Years",{"count":64,"type":65},60,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to investigate the acute cardiovascular effects of ultra-endurance running using comprehensive echocardiographic assessment combined with biological analyses. The main hypothesis is that participation in an ultra-trail race induces acute and transient changes in cardiac function involving both the left and right ventricles, associated with elevations in cardiac biomarkers, with physiological responses varying according to race distance and training level and showing spontaneous recovery within the days following the event.\n\nAdult amateur runners participating in ultra-trail races of 80 km or 160 km will undergo standardized clinical evaluation, electrocardiography, and transthoracic echocardiography with myocardial deformation analysis at multiple time points, including baseline, pre-effort, during the race, immediately after exercise, and during early recovery approximately one week after the event. Biological sampling will be performed before the race, immediately after exercise, and at follow-up.\n\nThe primary objective is to evaluate acute changes in left ventricular systolic function assessed by global longitudinal strain. Secondary objectives include the assessment of biventricular and atrial function, cardiac and non-cardiac biomarkers, recovery patterns after ultra-endurance exercise, and the influence of race distance, training level, performance level, and sex on cardiovascular responses.\n\nThis exploratory single-center study conducted in France seeks to provide an integrative characterization of cardiac adaptations to extreme endurance exercise and to generate physiological insights that may guide future research and cardiovascular monitoring strategies in endurance athletes.",[69,70,71],"Exercise","Cardiac Function","Echocardiography",[73,74,75,76],"Ultra-endurance exercise","Ultra-trail running","Myocardial strain","Cardiac biomarkers","NOT_YET_RECRUITING","2026-08-04",{"date":80,"type":81},"2026-08-07","ACTUAL",{"date":83,"type":65},"2027-05",{"date":83,"type":65},{"name":5,"class":6},1]