[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613473":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":26,"locations":36,"responsibleParty":55,"collaborators":21,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":21,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":21,"enrollmentInfo":67,"targetDuration":21,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":21,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"China Medical University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"TENS Group","EXPERIMENTAL","Acupoint TENS Intervention (TENS Group) Participants in this group received low-frequency transcutaneous electrical nerve stimulation (TENS) applied to clinically recognized analgesic acupoints, Zhongzhu (SJ3) and Hegu (LI4). Each participant completed two intervention sessions in a randomized order, with at least 48 hours between sessions. During each session, participants first underwent a baseline assessment of pain-related evoked potentials (PREPs), followed by a 20-minute TENS application delivered through surface electrodes placed directly over the target acupoint. The stimulation parameters included low frequency and low-intensity currents adjusted to a comfortable but perceptible level. Immediately after the stimulation period, participants received a follow-up PREP assessment to evaluate changes in nociceptive cortical processing. Subjective pain responses and any discomfort or adverse reactions were recorded throughout the procedure. The entire protocol was designed to deter",[13,14],"Device: transcutaneous electrical nerve stimulation (TENS)","Device: EEG machine",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DEVICE","transcutaneous electrical nerve stimulation (TENS)","TENS was applied to the acupoints Zhongzhu (SJ3) and Hegu (LI4) using surface electrodes. Low-frequency electrical currents were delivered at an intensity that was comfortable but perceptible, without causing muscle contraction. Each session lasted 20 minutes, during which participants remained seated and relaxed, and electrode placement and stimulation parameters were monitored for safety and consistency.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"EEG machine","EEG signals were recorded using the Neuro-MEP4 system. The device captures cortical electrical activity with high temporal resolution and is suitable for measuring pain-related evoked potentials (PREPs). Standard electrode placement and recording protocols were followed, and signal quality was checked before each session to ensure reliable data collection.",[9],[27,32],{"name":28,"role":29,"phone":30,"phoneExt":21,"email":31},"Yueh-Ling Hsieh","CONTACT","04-22053366 Ext. #7312","sherrie@mail.cmu.edu.tw",{"name":33,"role":29,"phone":34,"phoneExt":21,"email":35},"Yung-Yu Hsu","0973060827","celeste30153@gmail.com",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Department of Physical Therapy of China Medical University","RECRUITING","Taichung","Beitun, Taiwan","406040","Taiwan","TW",{"type":46,"coordinates":47},"Point",[48,49],120.6839,24.1469,{"lat":49,"lon":48},[52],{"name":38,"role":29,"phone":53,"phoneExt":21,"email":54},"04-22053366 Ext.#7301","aca70@mail.cmu.edu.tw",{"type":56,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100613473","acute-effects-of-transcutaneous-electrical-nerve-stimulation-at-acupoints-on-nociceptive-transmission-100613473",false,"NCT07267052","Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission","Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission: A Mechanism Study Using Pain-Related Evoked Potentials","Inclusion Criteria:\n\n* Healthy Adult\n* 20 years or older\n* The absence of chronic medical conditions\n* No history of drug allergies\n* No skin disorders\n* No current use of medications that could affect study outcomes\n* Participants maintain a regular daily routine\n* No history of substance or medication abuse\n\nExclusion Criteria:\n\n* History of malignant tumors\n* History of hand disorders\n* Has implanted cardiac pacemakers\n* Pregnancy\n* Epilepsy\n* Any other condition that may interfere with the study procedures",true,"ALL","20 Years",{"count":68,"type":69},35,"ESTIMATED","INTERVENTIONAL",[72],"NA","The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) applied to acupoints can modulate pain transmission and cortical processing in healthy adult volunteers. The main questions it aims to answer are:\n\n* Does TENS at Zhongzhu (SJ3) and Hegu (LI4) change pain-related evoked potentials (PREPs)?\n* Does acupoint electrical stimulation alter nociceptive pathways reflected by PREP waveform modulation?\n\nResearchers will compare PREPs recorded before and after TENS at the two acupoints to see if TENS produces measurable effects on cortical nociceptive responses.\n\nParticipants will receive low-frequency TENS applied to Zhongzhu (SJ3) and Hegu (LI4), and undergo PREP assessments before and after the intervention to measure cortical responses to standardized noxious stimuli.",[75],"Pain Management",[77,78,79,80,81],"Somatosensory Evoked Potentials","Transcutaneous Electrical Nerve Stimulation","Pain-Related Evoked Potentials","Zhongzhu","Hegu","2026-07-06",{"date":84,"type":85},"2026-07-08","ACTUAL",{"date":87,"type":85},"2025-09-05",{"date":89,"type":69},"2026-07-31",{"name":5,"class":6},1]