[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100648108":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":49,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":71,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"East and North Hertfordshire NHS Trust","OTHER_GOV",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"HDF group",null,"Particiapants receiving hemodiafiltration",{"label":13,"type":10,"description":14,"interventionNames":10},"HD group","Participants receiving high flux hemodialysis",{"label":16,"type":10,"description":17,"interventionNames":10},"Low dialysate sodium group","Participants dialysing with dialysate sodium concentration 137 mmol\u002FL",{"label":19,"type":10,"description":17,"interventionNames":10},"High dialysate sodium group",[21],{"name":22,"affiliation":5,"role":23},"Usama Afzal Butt, MBBS, MRCP","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Usama Afzal Butt, MBBS, MRCP (UK)","CONTACT","+441438284340","usama.butt1@nhs.net",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Lister Hospital, East and North Hertfordshire NHS Trust","RECRUITING","Stevenage","Hertfordshire","SG1 4AB","United Kingdom","UK",{"type":40,"coordinates":41},"Point",[42,43],-0.20256,51.90224,{"lat":43,"lon":42},[46,47],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":48,"role":23,"phone":10,"phoneExt":10,"email":10},"Enric Vilar, MBChB, MRCP, PhD",{"type":50,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100648108","adequacy-of-haemodiafiltration-middle-molecules-clearance-patients-reported-outcomes-and-sodium-balance-100648108",false,"NCT07717255","Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance","Inclusion Criteria:\n\n* Age 18 years or above.\n* Ability to give informed consent.\n* End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.\n* Prognosis \\> 6 months as assessed by principal investigator (PI)","ALL","18 Years",{"count":60,"type":61},300,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (\\>23Litres (L)) vs Low (\\\u003C23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol\u002FL) on overhydration volume in patients on HD and HDF.",[65,66,67,68,69,70],"Haemodiafiltration","Haemodialysis","Patient Reported Outcome Measurements","Nutrition","Malnutrition (Calorie)","Fluid Balance Outcomes",[72,73,74,75],"Middle molecules clearance in haemodiafiltraion","Effect of dialysis clearance on nutritional status","Effect of dialysis clearance on patient reported outcome measure","Effect of dialysate sodium on fluid status","2026-07-16",{"date":78,"type":79},"2026-07-21","ACTUAL",{"date":81,"type":79},"2025-01-09",{"date":83,"type":61},"2030-11-01",{"name":5,"class":6},1]