[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646707":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":10,"locations":19,"responsibleParty":43,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":59,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":22,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Istituto Clinico Humanitas","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":11},"Adult patients without acute respiratory failure undergoing mechanical ventilation.",null,[12],"Diagnostic Test: Advanced Non-Invasive Respiratory Monitoring",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Advanced Non-Invasive Respiratory Monitoring","Continuous measurement and recording of airway pressure, esophageal pressure, inspiratory and expiratory flow, and electrical impedance tomography (EIT) data during the first 24 hours of mechanical ventilation. A nasogastric tube equipped with an esophageal balloon is placed alongside an EIT electrode belt. Monitoring is performed continuously off-line without altering standard clinical management. Residual respiratory function is also evaluated via spirometry and EIT prior to Intensive Care Unit (ICU) discharge.",[9],[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Humanitas Research Hospital","RECRUITING","Milan","Lombardy","20089","Italy","IT",{"type":29,"coordinates":30},"Point",[31,32],9.18951,45.46427,{"lat":32,"lon":31},[35,40],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Giulia Lionetti GL Medical Doctor and Anesthesiologist, Medicine and Anesthesiology","CONTACT","0282243789","giulia.lionetti@humanitas.it",{"name":41,"role":37,"phone":38,"phoneExt":10,"email":42},"Alessandro Santini AS Medical Doctor and Anesthesiologist, Medicine and Anesthesiology","alessandri.santini@humanitas.it",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Michele Tedeschi","Medical Doctor","100646707","advanced-respiratory-monitoring-for-safer-mechanical-ventilation-in-patients-without-respiratory-failure-100646707",false,"NCT07686315","Advanced Respiratory Monitoring for Safer Mechanical Ventilation in Patients Without Respiratory Failure","ADAPT","Study Population Eligibility Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No\n\nInclusion Criteria:\n\nAdult patients +18 years. Undergoing invasive mechanical ventilation for reasons other than acute respiratory failure (such as coma, trauma, or sepsis).\n\nInitiation of monitoring within 24 hours of oro-tracheal intubation.\n\nExclusion Criteria:\n\nEvidence of pneumothorax, pneumomediastinum, or subcutaneous emphysema. Pregnancy. Absolute contraindications to nasogastric tube placement. Absolute contraindications to electrical impedance tomography (EIT) monitoring.","ALL","18 Years",{"count":57,"type":58},40,"ESTIMATED","3 Years","OBSERVATIONAL","Patients admitted to the intensive care unit (ICU) and mechanically ventilated for reasons other than acute respiratory failure, such as coma, trauma, or sepsis, are at risk of developing acute respiratory distress syndrome (ARDS), which increases the duration of mechanical ventilation, mortality, and functional dependence at discharge.",[63],"Developing Acute Respiratory Distress Syndrome",[65],"ARDS","2026-06-30",{"date":68,"type":69},"2026-07-07","ACTUAL",{"date":66,"type":58},{"date":72,"type":58},"2026-12-30",{"name":5,"class":6},1]