[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543431":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":33,"centralContacts":37,"locations":43,"responsibleParty":61,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":27,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":27,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":45,"whyStopped":27,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,14,18],{"label":9,"type":6,"description":10,"interventionNames":11},"Opioid use disorder (OUD) group","This group takes buprenorphine and has OUD.",[12,13],"Other: Magnetic Resonance Imaging (MRI)","Behavioral: Computer Tasks",{"label":15,"type":6,"description":16,"interventionNames":17},"Buprenorphine (BUP) control group:","This group takes BUP and does not have OUD.",[12,13],{"label":19,"type":6,"description":20,"interventionNames":21},"Healthy Controls group","This group does not take BUP and does not have OUD.",[12,13],[23,28],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"Magnetic Resonance Imaging (MRI)","Enrolled participants will have one MRI during the study on day 2 after having Day 1 visit. During the MRI the participants will complete various tasks.",[15,19,9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"BEHAVIORAL","Computer Tasks","Eligible participants will complete computer tasks (cognitive tasks, spatial navigation tasks, context dependent fear learning, etc.) at visit 1 and then during the MRI.",[15,19,9],[34],{"name":35,"affiliation":5,"role":36},"Elizabeth Duval","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":27,"email":42},"Aml Almamri","CONTACT","734-232-0190","AdversityBrainOUD@med.umich.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Ann Arbor","Michigan","48109","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-83.74088,42.27756,{"lat":55,"lon":54},[58,59],{"name":39,"role":40,"phone":27,"phoneExt":27,"email":42},{"name":60,"role":36,"phone":27,"phoneExt":27,"email":27},"Elizabeth Duval, PhD",{"type":36,"investigatorFullName":35,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Associate Professor of Psychiatry",[64],{"name":65,"class":66},"National Institute on Drug Abuse (NIDA)","NIH","100543431","adversity-brain-and-opioid-use-study-100543431",false,"NCT06355778","Adversity, Brain and Opioid Use Study","A Mechanistic Investigation of Risk Factors for Opioid Use Disorder: Examining Hippocampal-based Context-dependent Learning and Memory Associated With Adverse Childhood Experiences","Inclusion Criteria for all groups:\n\n* Fluent in English\n* Able to give informed consent\n* Normal\u002Fcorrected-to-normal vision and hearing\n\nInclusion Criteria for Opioid Use Disorder (OUD) group:\n\n* Diagnosis of OUD\n* Be actively receiving buprenorphine (BUP) for opioid agonist therapy\n* Be free from illicit substance use for at least 2 weeks\n* The study will allow stable dose (\\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)\n\nInclusion Criteria for the BUP control group:\n\n* Taking BUP for chronic pain\n* No Substance Use Disorder (including OUD)\n* The study will allow stable dose (\\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)\n\nInclusion Criteria for Healthy participant group:\n\n* Not taking BUP\n* Free of any psychiatric or major medical conditions\n\nExclusion Criteria for all groups:\n\n* Pregnancy\n* Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)\n* Actively suicidal\n* Contraindication for MRI\n* Inability to tolerate small, enclosed spaces without anxiety or unable to fit comfortably in the MRI scanner\n* Life history of schizophrenia, learning disability, attention deficit disorder, or pervasive developmental disorder\n* Use of substances or prescription medications that could interfere with measures of interest (per protocol)\n* Unable to provide informed consent\n* Participants who have completed other studies in our lab involving learning and memory assessments with the same\u002Fsimilar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due to possible learning\u002Fpractice effects",true,"ALL","18 Years","55 Years",{"count":79,"type":80},185,"ESTIMATED","INTERVENTIONAL",[83],"NA","The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.",[86,87],"Opioid Use Disorder","Healthy",[24,89,90,91,92],"Adverse Childhood Experiences","Fear Learning","Memory","Hippocampal function","2026-07-15",{"date":95,"type":96},"2026-07-17","ACTUAL",{"date":98,"type":96},"2025-01-09",{"date":100,"type":80},"2028-04",{"name":5,"class":6},1]