[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652727":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":20,"responsibleParty":30,"collaborators":33,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":20,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":20,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":61,"whyStopped":20,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":20},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Acute aerobic exercise- Interventional Group","EXPERIMENTAL","This group will include all enrolled participants from all age groups, will receive MRI scans for glymphatic function and participate in acute aerobic exercise (intervention) between MRI sessions. They may \u002F may not undergo PET scans.",[13],"Procedure: Acute Aerobic exercise",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Acute Aerobic exercise","During the MRI session, subject will perform aerobic exercise on a MR-compatible ergometer and will be guided to reach certain heart rate level depending on subject's age. Their vital signs will be closely monitored by the research team to ensure safety.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Jiaen Liu, Ph.D.","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","612\u002F423-8380","Jiaen.Liu@UTSouthwestern.edu",{"type":24,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Jiaen Liu","Assistant Professor",[34],{"name":35,"class":36},"National Institute on Aging (NIA)","NIH","100652727","aging-and-exercise-impacts-on-glymphatic-function-100652727",false,"NCT07775196","Aging and Exercise Impacts on Glymphatic Function","Impact of Aging and Exercise on Glymphatic Function Using Multi-modal MRI","Inclusion Criteria:\n\n* age 25-75 years old\n* cognitively unimpaired (CU)\n* Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening\n* matched gender\n* all racial\u002Fethnic groups\n\nExclusion Criteria:\n\n* pregnant women\n* history of stroke or other major cerebrovascular disease;\n* diagnosis of Alzheimer's disease (AD) or other types of dementia;\n* diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression);\n* history of prior head trauma, significant autoimmune disorders,\n* sleep apnea;\n* major systemic illness likely to affect the central nervous system, e.g., uncontrolled diabetes, severe cardiovascular disease, cancer, etc.;\n* prior or current alcoholism or drug abuse;\n* resistant hypertension (SBP ≥140 or DBP ≥ 90 mmHg despite 3 antihypertensive drugs at maximal doses);\n* orthostatic hypotension defined as the third standing systolic blood pressure (SBP) \\\u003C 100mmHg; any contraindications to having a MRI, e.g., claustrophobia, pacemaker or other medical device of metal;\n* any conditions judged by the investigators to be medically inappropriate, risky or likely to cause poor study compliance.",true,"ALL","25 Years","75 Years",{"count":49,"type":50},240,"ESTIMATED","INTERVENTIONAL",[53],"NA","This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session.\n\nHypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.",[41],[57,58,59,60],"Aging","Exercise","Glymphatic Function","Alzheimer's Disease","NOT_YET_RECRUITING","2026-08-17",{"date":64,"type":65},"2026-08-20","ACTUAL",{"date":67,"type":50},"2026-12",{"date":69,"type":50},"2029-12",{"name":5,"class":6}]