[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645733":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":55,"collaborators":18,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":9,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":18,"enrollmentInfo":67,"targetDuration":18,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":81,"whyStopped":18,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-CONECT","EXPERIMENTAL","Participants will receive four 15-minute conversations per week with the AI agent and a weekly 15-minute survey call with a human interviewer.",[13],"Behavioral: AI-based conversational intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Participants will receive a weekly 15-minute survey call with a human interviewer.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","AI-based conversational intervention","AI-based one-on-one semi-structured conversation for cognitive stimulation",[9],[26],{"name":27,"affiliation":5,"role":28},"Hiroko H Dodge, PhD","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Catherine Young","CONTACT","617-724-2428","cyoung@mgh.harvard.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Junyuan Hong, PhD","517-668-5790","jhong28@mgh.harvard.edu",[40],{"facility":5,"status":18,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Boston","Massachusetts","02129","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-71.05977,42.35843,{"lat":50,"lon":49},[53,54],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},{"type":28,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Hiroko Hayama Dodge","Professor","100645733","ai-conect-a-conversational-ai-for-early-dementia-prevention-in-socially-isolated-older-adults-100645733",false,"NCT07701668","AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults","AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults Based on the Efficacy-Proven I-CONECT Study","Inclusion Criteria:\n\n* Aged 75+\n* Clinical diagnosis of MCI, or MMSE ≥ 24 or MoCA ≥ 18 (i.e., early MCI)\n* Identified as socially isolated by at least one of the two criteria: (1)score ≤ 12 on the 6-item Lubben Social Network Scale (LSNS-6); (2) engages in conversations lasting 30 minutes or longer, no more than twice per week, per subject self-report\n* GDS-15 (15-item Geriatric Depression Scale) at\u002Fbelow 9 (not severely depressed).\n* Social self-efficacy mean ≤ 8 (on the 0-10 scale) across the 6-item Social Self-Efficacy Scale at screening, indicating low confidence in social interaction.\n* Ability to understand the research consent form.\n* Ability to connect a tablet to the Internet.\n\nExclusion Criteria:\n\n* Diagnosed with dementia such as AD, ischemic vascular dementia, normal pressure hydrocephalus, or Parkinson's disease.\n* Schizophrenia, or other major psychiatric disorder defined by DSM-IV criteria.\n* Medications: Frequent use of high doses of analgesics; Use of sedative medications except for those used occasionally for sleep (≤2 per week); Use of unstable dosing of Cholinesterase inhibitors (need to be stable dosing for 2 months).","ALL","75 Years",{"count":68,"type":69},80,"ESTIMATED","INTERVENTIONAL",[72],"NA","This randomized controlled trial examines the mechanisms of conversational AI-based interventions for early dementia prevention in socially isolated older adults.",[75,76],"Mild Cognitive Impairment (MCI)","Social Isolation",[76,78,79,80,75],"Artificial Intelligence","AI-Chatbot","I-CONECT","NOT_YET_RECRUITING","2026-07-13",{"date":84,"type":85},"2026-07-14","ACTUAL",{"date":87,"type":69},"2026-07-30",{"date":89,"type":69},"2028-03-31",{"name":5,"class":6},1]