[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647492":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":59,"collaborators":24,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":24,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":24,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":24,"overallStatus":36,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (Control Group)","ACTIVE_COMPARATOR","Patients will receive a conventional pressure support ventilation protocol.",[13],"Other: Pressure support ventilation protocol",{"label":15,"type":16,"description":17,"interventionNames":18},"Group II (Study Group)","EXPERIMENTAL","Patients will receive airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV).",[19],"Other: Airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV)",[21,25],{"type":6,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"Pressure support ventilation protocol",[9],null,{"type":6,"name":26,"description":17,"armGroupLabels":27,"otherNames":24},"Airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV)",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Muhammad A Kandil, MSc","CONTACT","00201022644722","muhammad.kandil@med.tanta.edu.eg",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Tanta","Al Gharbia","31527","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],31.00192,30.78847,{"lat":46,"lon":45},[49,50,53,55,57],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},{"name":51,"role":52,"phone":24,"phoneExt":24,"email":24},"Sohair M Soliman, MD","SUB_INVESTIGATOR",{"name":54,"role":52,"phone":24,"phoneExt":24,"email":24},"Ghada F Elbaradey, MD",{"name":56,"role":52,"phone":24,"phoneExt":24,"email":24},"Taysser M Abdalraheem, MD",{"name":58,"role":52,"phone":24,"phoneExt":24,"email":24},"Aliaa M Belal, MD",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Muhammad Ahmed Kandil","Assistant Lecturer of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Tanta University, Egypt.","100647492","airway-occlusion-pressure-p01-guided-pressure-support-ventilation-versus-conventional-management-in-weaning-window-patients-100647492",false,"NCT07709182","Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients","Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Mechanically ventilated adult patients ≥ 21 years.\n* Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status.\n* Hemodynamically stable \\[mean arterial pressure (MAP) ≥60 mmHg\\].\n* All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive.\n\nExclusion Criteria:\n\n* Patients with neuromuscular disorders affecting respiratory drive\n* Glasgow Coma Scale (GCS) score below 8\n* Cervical spinal cord injury\n* Receipt of neuromuscular blockers within the previous 24 hours\n* Morbid obesity resulting in unreliable respiratory mechanics\n* Pregnancy\n* Deep sedation defined as RASS ≤ -2\n* Hemodynamic instability requiring escalating vasopressor support.","ALL","21 Years",{"count":73,"type":74},80,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.",[80,81,82,83],"Airway Occlusion Pressure","Pressure Support Ventilation","Conventional Management","Weaning Window Patients","2026-07-11",{"date":86,"type":87},"2026-07-16","ACTUAL",{"date":89,"type":87},"2026-02-01",{"date":91,"type":74},"2028-01-01",{"name":5,"class":6},1]