[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100652786":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":33,"centralContacts":37,"locations":28,"responsibleParty":43,"collaborators":28,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":28,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":68,"whyStopped":28,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":28},{"fullName":5,"class":6},"University of Illinois at Urbana-Champaign","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: lactating women dose response","EXPERIMENTAL","Lactating women who will drink \\~ 1 or 2 standard drinks of alcohol",[13],"Other: Low-alcohol level exposure",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2: timing of pumping","Lactating women will pump at two different times from alcohol drinking",[18],"Other: Breast-pumping time",{"label":20,"type":6,"description":21,"interventionNames":22},"Aim 3: non-lactating control women","Non-lactating women of similar age, BMI, and alcohol consumption characteristics will drink a similar dose of alcohol as lactating women for the assessment of systemic alcohol-related measurements. This group will serve as a comparison group for interpreting alcohol-related measurements in lactating participants.",[13],[24,29],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Low-alcohol level exposure","Participants will consume a protocol-specified low-level alcohol exposure under study conditions. The assigned dose and biospecimen collection procedures will vary by study group.",[20,9],null,{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Breast-pumping time","Breast pumping before or after drinking \\~ 1 standard drink",[15],[34],{"name":35,"affiliation":5,"role":36},"Marta Y Pepino de Gruev","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":28,"email":42},"Marta Y Pepino de Gruev, Ph D","CONTACT","217-300-2374","ypepino@illinois.edu",{"type":44,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100652786","alcohol-breast-cancer-and-metabolism-100652786",false,"NCT07779967","Alcohol, Breast Cancer, and Metabolism","Localized Mammary Alcohol Metabolism as a Mechanism Linking Low-Level Alcohol Intake to Breast Cancer Risk","ABC-Met","Inclusion Criteria:\n\nAll aims\n\n-Drink alcohol (at least one alcoholic drink during lactation of a lactating female)\n\nFor aims 1 and 2\n\n* Nursing a 2- to 5-month-old infant\n* Experienced with a breast pump\n\nExclusion Criteria:\n\n* Pregnant\n* Lifetime history of alcohol dependence\n* Drink more than 3 standard drinks per day or more than 7 standard drinks per week in the month previous to enrollment\n* Current regular use of drugs with addiction potential (other than alcohol)\n* Use of medications known to interact with alcohol metabolism\n* Current smoking\n* Anemia\n* Diabetes\n* Liver disease",true,"FEMALE","21 Years","45 Years",{"count":58,"type":59},50,"ESTIMATED","INTERVENTIONAL",[62],"NA","Alcohol consumption, even at low levels, has been associated with increased breast cancer risk, but the biological mechanisms underlying this relationship remain unclear. This study will examine whether breast tissue may locally metabolize alcohol by measuring alcohol-related compounds in paired blood and breast milk samples from lactating women. The findings may help clarify alcohol-related biological pathways relevant to breast cancer risk and improve risk communication.",[65],"Focus of Study: Alcohol Metabolism in the Breast",[67],"lactating women, alcohol metabolism, breastmilk, ethanol","NOT_YET_RECRUITING","2026-08-18",{"date":71,"type":72},"2026-08-21","ACTUAL",{"date":74,"type":59},"2026-07-27",{"date":76,"type":59},"2032-03-01",{"name":5,"class":6}]