[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100649192":3},{"organization":4,"armGroups":7,"interventions":99,"overallOfficials":123,"centralContacts":129,"locations":138,"responsibleParty":156,"collaborators":159,"id":163,"slug":164,"hasResults":165,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":165,"sex":171,"minAge":172,"maxAge":11,"enrollmentInfo":173,"targetDuration":11,"studyType":176,"phases":177,"briefSummary":179,"conditions":180,"keywords":11,"overallStatus":182,"whyStopped":11,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":192},{"fullName":5,"class":6},"University of Michigan","OTHER",[8,15,19,22,25,28,31,34,37,40,44,47,50,54,57,60,63,66,69,72,75,78,81,84,87,90,93,96],{"label":9,"type":10,"description":11,"interventionNames":12},"Physical Therapy & Exercise and continue","EXPERIMENTAL",null,[13,14],"Device: Algorithmically informed randomization (taking into account phenotypes)","Behavioral: Physical Therapy (PT) and Exercise",{"label":16,"type":10,"description":11,"interventionNames":17},"Physical Therapy & Exercise followed by Duloxetine",[13,14,18],"Drug: Duloxetine",{"label":20,"type":10,"description":11,"interventionNames":21},"Physical Therapy & Exercise followed by PRISM-CBT",[13,14],{"label":23,"type":10,"description":11,"interventionNames":24},"Physical Therapy & Exercise followed by Acupressure",[13,14],{"label":26,"type":10,"description":11,"interventionNames":27},"Physical Therapy & Exercise then add Duloxetine",[13,14,18],{"label":29,"type":10,"description":11,"interventionNames":30},"Physical Therapy & Exercise then add PRISM-CBT",[13,14],{"label":32,"type":10,"description":11,"interventionNames":33},"Physical Therapy & Exercise then add Acupressure",[13,14],{"label":35,"type":10,"description":11,"interventionNames":36},"Duloxetine and Continue",[13,18],{"label":38,"type":10,"description":11,"interventionNames":39},"Duloxetine followed by Physical Therapy & Exercise",[13,18],{"label":41,"type":10,"description":11,"interventionNames":42},"Duloxetine followed by PRISM-CBT",[13,43,18],"Behavioral: Cognitive-Behavioral Therapy for Pain (PRISM-CBT)",{"label":45,"type":10,"description":11,"interventionNames":46},"Duloxetine then add Physical Therapy & Exercise",[13,14,18],{"label":48,"type":10,"description":11,"interventionNames":49},"Duloxetine then add PRISM-CBT",[13,43,18],{"label":51,"type":10,"description":11,"interventionNames":52},"Duloxetine then add Acupressure",[13,53,18],"Behavioral: mHealth Acupressure Self-Management:",{"label":55,"type":10,"description":11,"interventionNames":56},"PRISM-CBT and continue",[13,43],{"label":58,"type":10,"description":11,"interventionNames":59},"PRISM-CBT followed by Physical Therapy & Exercise",[13,14,43],{"label":61,"type":10,"description":11,"interventionNames":62},"PRISM-CBT followed by Duloxetine",[13,43,18],{"label":64,"type":10,"description":11,"interventionNames":65},"PRISM-CBT followed by Acupressure",[13,43,53],{"label":67,"type":10,"description":11,"interventionNames":68},"PRISM-CBT then add Physical Therapy & Exercise",[13,14,43],{"label":70,"type":10,"description":11,"interventionNames":71},"PRISM-CBT then add Duloxetine",[13,43,18],{"label":73,"type":10,"description":11,"interventionNames":74},"PRISM-CBT then add Acupressure",[13,43,53],{"label":76,"type":10,"description":11,"interventionNames":77},"Acupressure then continue",[13,53],{"label":79,"type":10,"description":11,"interventionNames":80},"Acupressure followed by Duloxetine",[13,53,18],{"label":82,"type":10,"description":11,"interventionNames":83},"Acupressure followed by PRISM-CBT",[13,43,53],{"label":85,"type":10,"description":11,"interventionNames":86},"Acupressure then add Physical Therapy & Exercise",[13,14,53],{"label":88,"type":10,"description":11,"interventionNames":89},"Acupressure then add Duloxetine",[13,53,18],{"label":91,"type":10,"description":11,"interventionNames":92},"Acupressure then add PRISM-CBT",[13,43,53],{"label":94,"type":10,"description":11,"interventionNames":95},"Duloxetine followed by Acupressure",[13,18],{"label":97,"type":10,"description":11,"interventionNames":98},"Acupressure followed by Physical Therapy & Exercise",[13,14,53],[100,105,110,114,118],{"type":101,"name":102,"description":103,"armGroupLabels":104,"otherNames":11},"DEVICE","Algorithmically informed randomization (taking into account phenotypes)","After Phenotypic data is collected from participants, the algorithm will use that data to \"rank\" the likelihood of success of different treatments for an individual; it will then,randomize participants based on two patterns of assignment. And at visit 3, it will re-randomize those participants who wish to add an additional treatment modality or transfer from one modality to another.",[79,82,97,88,91,85,76,35,94,41,38,51,48,45,55,64,61,58,73,70,67,9,23,16,20,32,26,29],{"type":106,"name":107,"description":108,"armGroupLabels":109,"otherNames":11},"BEHAVIORAL","Physical Therapy (PT) and Exercise","A high-contact intervention (10 in-person sessions) involving individualized programs tailored to participant needs and guided by physical therapy best-practice guidelines. Treatment emphasizes home exercise, progressive low-intensity conditioning, and functional endurance.",[97,85,45,58,67,9,23,16,20,32,26,29],{"type":106,"name":111,"description":112,"armGroupLabels":113,"otherNames":11},"Cognitive-Behavioral Therapy for Pain (PRISM-CBT)","A moderate-contact telehealth intervention (8 virtual sessions) integrating standard CBT techniques with positive activity modules to enhance engagement, mood, and self-efficacy. Weekly modules focus on pacing, cognitive reframing, relaxation, gratitude, and acts of kindness.",[82,91,41,48,55,64,61,58,73,70,67],{"type":106,"name":115,"description":116,"armGroupLabels":117,"otherNames":11},"mHealth Acupressure Self-Management:","A low-contact, self-guided intervention delivered via the MeTime mobile application, supported by brief staff instruction. Participants practice daily self-acupressure at ten standardized points for approximately 30 minutes per day, stimulating key acupoints associated with pain modulation.",[79,82,97,88,91,85,76,51,64,73],{"type":119,"name":120,"description":121,"armGroupLabels":122,"otherNames":11},"DRUG","Duloxetine","This is a serotonin-norepinephrine reuptake inhibitor (SNRI) FDA-approved for chronic pain. A low-contact pharmacologic intervention consisting of an 8-week dose escalation of 60 mg duloxetine, followed by taper as indicated. Participants initiate medication at home after a standardized orientation, with remote safety and adherence check-ins.",[79,88,35,94,41,38,51,48,45,61,70,16,26],[124,127],{"name":125,"affiliation":5,"role":126},"Afton Hassett, PsyD","PRINCIPAL_INVESTIGATOR",{"name":128,"affiliation":5,"role":126},"Daniel Clauw, MD",[130,135],{"name":131,"role":132,"phone":133,"phoneExt":11,"email":134},"Beth Banner","CONTACT","734-763-5226","eledward@med.umich.edu",{"name":136,"role":132,"phone":133,"phoneExt":11,"email":137},"Sana Shaikh","skazi@med.umich.edu",[139],{"facility":5,"status":11,"city":140,"state":141,"zip":142,"country":143,"countryCode":144,"cosmosGeoPoint":145,"geoPoint":150,"contacts":151},"Ann Arbor","Michigan","48109","United States","US",{"type":146,"coordinates":147},"Point",[148,149],-83.74088,42.27756,{"lat":149,"lon":148},[152,153,154,155],{"name":131,"role":132,"phone":133,"phoneExt":11,"email":134},{"name":136,"role":132,"phone":133,"phoneExt":11,"email":137},{"name":125,"role":126,"phone":11,"phoneExt":11,"email":11},{"name":128,"role":126,"phone":11,"phoneExt":11,"email":11},{"type":126,"investigatorFullName":157,"investigatorTitle":158,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Afton Hassett, Psy.D.","Associate Professor of Anesthesiology, Associate Professor of Internal Medicine and Program Director, Anesthesiology",[160],{"name":161,"class":162},"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","NIH","100649192","algorithm-informed-decision-making-to-advance-pain-treatment-100649192",false,"NCT07731750","Algorithm-informed Decision-making to Advance Pain Treatment","Algorithm-informed Decision-making to Advance Pain Treatment (ADAPT Study)","ADAPT","Inclusion Criteria:\n\n* Participants must meet the definition of Chronic Low Back Pain (cLBP) described in the NIH Task Force Report on Research Standards for cLBP, i.e., low back pain present at least six months, and present more than half of those days.2\n* Individuals must have a pain interference score of ≥60 on PROMIS Pain Interference. The normal population mean for pain interference is 50. Participants must be 1 standard deviation (SD) above the population mean (\\>=60) for inclusion.\n* Individuals must be willing and eligible to receive at least three of the four proposed interventions.\n* Able to stand for at least 10 minutes\n\nExclusion Criteria:\n\n* Red flags suggesting the presence of an identifiable cause of low back pain, including fever, weight loss, initiation of pain following major trauma, immunosuppression, IV drug use, recent bacterial infection, severe or persistent sensory or motor involvement of bowel, bladder, or lower extremity.\n* Unable to read, write of speak fluent English\n* Visual or hearing difficulties that would preclude participation\n* Active uncontrolled drug\u002Falcohol addiction\n* Individuals receiving new disability or compensation or involved in litigation in the past 12 months.\n* Pregnancy or breastfeeding\n* Individuals on high doses of opioids (over 100 Oral Morphine Equivalents \\[OME\\] per day).\n* Upcoming scheduled back surgery, back surgery within the last year, or more than one back surgery in the past.\n* History of discitis osteomyelitis (spine infection) or spine tumor\n* History of an autoimmune disorder such as ankylosing spondylitis, rheumatoid arthritis, polymyalgia rheumatica, psoriatic arthritis, or lupus\n* History of cauda equina syndrome or spinal radiculopathy\n* Diagnosis of schizophrenia or schizoaffective diagnosis\n* Diagnosis of any vertebral fracture in the last 6 months\n* Osteoporosis requiring treatment (vitamin D and calcium supplements are acceptable)\n* Cancer\n\n  * History of any bone-related cancer or cancer that metastasized to the bone\n  * Currently in treatment for cancer or plan to start cancer treatment in the next 12 months\n  * History of any cancer treatment in the last 24 months\n* Life expectancy is less than 2 years\n* Current\u002Fplanned (in the next 2 years) enrollment in another study of a device or investigational drug that would interfere with this study, this may include participation in a blinded trial.\n* Any other diseases or conditions that would make a patient unsuitable for study participation as determined by the site principal investigators. This would include but not be limited to severe psychiatric disorders, active suicidal ideations or recent suicide attempts","ALL","25 Years",{"count":174,"type":175},500,"ESTIMATED","INTERVENTIONAL",[178],"NA","Researchers are exploring how certain personal factors, such as symptoms, health history, and lifestyle, may help predict which treatments will work best for someone.\n\nThe purpose of this study is to evaluate how well a study algorithm chooses the best treatments for a patient when considering their unique pain characteristics.",[181],"Chronic Low-back Pain","NOT_YET_RECRUITING","2026-07-22",{"date":185,"type":186},"2026-07-28","ACTUAL",{"date":188,"type":175},"2026-07",{"date":190,"type":175},"2030-07",{"name":5,"class":6},1]