[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100374560":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":14,"centralContacts":18,"locations":29,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":10,"maxAge":10,"enrollmentInfo":60,"targetDuration":63,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Alpha-1 Foundation","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Alpha-1 Diagnosed Individuals",null,"Larger patient cohorts are needed to support the clinical trials coming in the next 3-5 years. Despite widespread invitations to the Alpha-1 community from the Alpha-1 Foundation Research Registry, it is estimated that the Alpha-1 Foundation Research Registry now contains \\\u003C40% of the identified PiZZ individuals in the US.",{"label":13,"type":10,"description":11,"interventionNames":10},"Carriers of Alpha-1",[15],{"name":16,"affiliation":5,"role":17},"Jeanine D'Armiento, MD, PhD","PRINCIPAL_INVESTIGATOR",[19,25],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},"Alison Keaveny, MBBS","CONTACT","1-877-228-7321","252","akeaveny@alpha1.org",{"name":26,"role":21,"phone":22,"phoneExt":27,"email":28},"Randel Plant","306 or 245","rplant@alpha1.org",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Coral Gables","Florida","33134","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-80.26838,25.72149,{"lat":41,"lon":40},[44,45,49],{"name":20,"role":21,"phone":22,"phoneExt":23,"email":24},{"name":46,"role":21,"phone":22,"phoneExt":47,"email":48},"Nadine Nuchovich, MPH","245","nnuchovich@alpha1.org",{"name":16,"role":17,"phone":10,"phoneExt":10,"email":10},{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100374560","alpha-1-research-registry-100374560",false,"NCT04157049","Alpha-1 Research Registry","Alpha-1 Research Registry Protocol","Inclusion Criteria:\n\n* Patients diagnosed with Alpha-1 Antitrypsin Deficiency (PiZZ, PiZNull, PiSZ etc.)\n* Alpha-1 carriers (PiMZ, PiMS etc.)\n\nExclusion Criteria:\n\n* Failure to provide informed consent\n* Normal healthy individuals (MM)","ALL",{"count":61,"type":62},5000,"ESTIMATED","3 Years","OBSERVATIONAL","The Alpha-1 Research Registry is a confidential database made up of individuals diagnosed with Alpha-1 Antitrypsin Deficiency (Alpha-1) and individuals identified as Alpha-1 carriers. The Registry was established to facilitate research initiatives and promote the development of improved treatments and a cure for Alpha-1.",[67],"Alpha 1-Antitrypsin Deficiency",[69,70,71,72,73,74,75,76,77,78],"AATD","ALPHA 1","COPD","AAT","ZZ","MZ","CARRIER","MM","MS","PiZZ","2026-08-18",{"date":81,"type":82},"2026-08-19","ACTUAL",{"date":84,"type":82},"2019-06-20",{"date":86,"type":62},"2029-06-20",{"name":5,"class":6},1]