[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100646796":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":53,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":18,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":18,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Kaohsiung Veterans General Hospital.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Alpha-Lipoic Acid + IVF","EXPERIMENTAL","Participants receive oral alpha-lipoic acid 600 mg\u002Fday for 2 months, followed by a standard controlled ovarian stimulation IVF cycle",[13],"Dietary Supplement: Alpha-Lipoic Acid (ALA)",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard IVF (Control)","NO_INTERVENTION","Participants proceed directly to a standard controlled ovarian stimulation IVF cycle without alpha-lipoic acid or any other antioxidant supplementation.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIETARY_SUPPLEMENT","Alpha-Lipoic Acid (ALA)","Oral Alpha-Lipoic Acid 600 mg\u002Fday for 2 months prior to IVF cycle initiation",[9],[26],{"name":27,"affiliation":5,"role":28},"Kuan-Hao Tsui","STUDY_DIRECTOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Li-Te Lin","CONTACT","+886-7-3464027","litelin1982@gmail.com",[36],{"facility":37,"status":38,"city":39,"state":18,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Kaohsiung Veterans General Hospital","RECRUITING","Kaohsiung City","813","Taiwan","TW",{"type":44,"coordinates":45},"Point",[46,47],120.31333,22.61626,{"lat":47,"lon":46},[50,51],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"name":31,"role":52,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":31,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Attending Physician","100646796","alpha-lipoic-acid-supplementation-and-ivf-outcomes-in-women-of-advanced-maternal-age-100646796",false,"NCT07685431","Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age","Effects of Alpha-Lipoic Acid Supplementation on Oocyte Quality, Cumulus Cell Mitochondrial Function, and In Vitro Fertilization Outcomes in Infertile Women of Advanced Maternal Age: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age 35-45 years\n* BMI 18-35 kg\u002Fm²\n* Planning to undergo IVF treatment using own oocytes\n\nExclusion Criteria:\n\n* Primary ovarian insufficiency\n* Azoospermia or severe male-factor infertility in the partner\n* Congenital uterine anomaly\n* Severe intrauterine adhesion\n* Known chromosomal anomaly in either partner\n* Malignancy\n* Recipient of donor oocytes\n* Known hypersensitivity\u002Fallergy to alpha-lipoic acid","FEMALE","35 Years","45 Years",{"count":66,"type":67},60,"ESTIMATED","INTERVENTIONAL",[70],"NA","Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment. Alpha-lipoic acid (ALA) is a potent antioxidant that crosses cell and mitochondrial membranes, regenerates other antioxidants (vitamin C, vitamin E, glutathione, coenzyme Q10), and supports mitochondrial respiratory chain activity and ATP production. This prospective study will enroll 60 infertile women aged 35-45 years undergoing in vitro fertilization (IVF) treatment. Thirty participants will receive oral ALA 600 mg\u002Fday for two months before their IVF cycle, and thirty will proceed directly to IVF without supplementation. The study will compare oocyte and embryo quality, cumulus cell mitochondrial function and metabolic gene expression, and clinical pregnancy and live birth rates between the two groups.",[73],"Female Infertility Due to Diminished Ovarian Reserve",[75,76,77,78,79,80],"Alpha-lipoic acid","In vitro fertilization","Advanced maternal age","Oocyte quality","Mitochondrial function","Cumulus cells","2026-07-03",{"date":83,"type":84},"2026-07-07","ACTUAL",{"date":86,"type":84},"2026-06-11",{"date":88,"type":67},"2028-06-30",{"name":5,"class":6},1]