[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607839":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":29,"studyPopulation":30,"armGroups":31,"interventions":49,"overallOfficials":25,"centralContacts":56,"locations":66,"responsibleParty":327,"collaborators":329,"id":334,"slug":335,"hasResults":336,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":336,"sex":342,"minAge":343,"maxAge":344,"enrollmentInfo":345,"targetDuration":25,"studyType":348,"phases":25,"briefSummary":349,"conditions":350,"keywords":25,"overallStatus":69,"whyStopped":25,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":363},{"fullName":5,"class":6},"Latin American Pediatric Collaborative Network","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"In-hospital mortality","Proportion of patients with PARDS who die during hospitalization. Mortality is defined as death during the same hospitalization period in which PARDS was diagnosed.","From PICU admission until hospital discharge (up to 90 days)",[14,17,21],{"measure":15,"description":16,"timeFrame":12},"New morbidity at hospital discharge","Presence of new functional morbidity measured using Functional Status Score greater than 2.",{"measure":18,"description":19,"timeFrame":20},"Ventilator-free days at 28 days.","Defined as the number of days a patient is alive and free from invasive mechanical ventilation during the first 28 days after initiation of ventilation. Patients who die within 28 days of initiation will be assigned a value of 0. For survivors, ventilator-free days will be calculated as 28 minus the total number of days on invasive mechanical ventilation during this period.","28 days after initiation of invasive mechanical ventilation",{"measure":22,"description":23,"timeFrame":24},"ICU-free days at 28 days.","Defined as the number of days a patient is alive and not admitted to the ICU during the first 28 days after ICU admission. Patients who die within 28 days of ICU admission will be assigned a value of 0. For survivors, ICU-free days will be calculated as 28 minus the total number of days spent in the ICU during this period.","28 days after ICU admission",null,{"allocation":25,"interventionModel":25,"interventionModelDescription":25,"primaryPurpose":25,"observationalModel":27,"timePerspective":28,"maskingInfo":25},"COHORT","PROSPECTIVE","Pediatric acute respiratory distress syndrome (PARDS) is a major cause of admission and mortality in pediatric intensive care units (PICUs). In high-altitude regions, hypoxemia may be exacerbated, complicating diagnostic interpretation and clinical decision-making. At the same time, variability in the availability of advanced resources-such as mechanical ventilation modes, monitoring systems, and trained personnel-could significantly influence outcomes.\n\nThis study will prospectively and retrospectively collect clinical, physiological, and institutional data from pediatric cohorts admitted to PICUs situated at different altitudes worldwide. The analysis will explore how altitude and structural resource differences interact with oxygenation and ventilation parameters to affect patient outcomes. The ultimate goal is to generate evidence that supports context-specific guidelines, reduces inequities in critical care delivery, and strengthens pediatric intensive care practices globally.","Mechanically ventilated children and adolescents (1 month-18 years) admitted to PICUs at different altitudes worldwide, who fulfill PALICC criteria for PARDS within 24 hours before or after intubation.",[32,37,41,45],{"label":33,"type":25,"description":34,"interventionNames":35},"Low Altitude PICUs","Children with PARDS admitted to pediatric intensive care units located at altitudes between 0-1500 meters above sea level.",[36],"Other: Geographic Altitude",{"label":38,"type":25,"description":39,"interventionNames":40},"Intermediate Altitude PICUs","Children with PARDS admitted to pediatric intensive care units located at altitudes between 1501-2500 meters above sea level.",[36],{"label":42,"type":25,"description":43,"interventionNames":44},"High Altitude PICUs","Children with PARDS admitted to pediatric intensive care units located at altitudes between 2501-3500 meters above sea level.",[36],{"label":46,"type":25,"description":47,"interventionNames":48},"Very High Altitude PICUs","Children with PARDS admitted to pediatric intensive care units located at altitudes above 3500 meters above sea level.",[36],[50],{"type":6,"name":51,"description":52,"armGroupLabels":53,"otherNames":54},"Geographic Altitude","Participants are grouped according to the altitude of the pediatric intensive care unit (PICU) where they are admitted: low altitude (0-1500 m), intermediate altitude (1501-2500 m), high altitude (2501-3500 m), and very high altitude (\\>3500 m). Altitude is treated as the primary exposure variable. No therapeutic intervention is administered as part of this study.",[42,38,33,46],[55],"Altitude Exposure",[57,62],{"name":58,"role":59,"phone":60,"phoneExt":25,"email":61},"PABLO VASQUEZ-HOYOS, MD, MSc","CONTACT","573187172029","pablovasquezmd@gmail.com",{"name":63,"role":59,"phone":64,"phoneExt":25,"email":65},"SEBASTIAN GONZALEZ-DAMBRAUSKAS, MD","59899585225","sgdambrauskas@gmail.com",[67,85,99,113,127,142,159,170,181,191,199,208,218,232,247,262,273,289,302,317],{"facility":68,"status":69,"city":70,"state":71,"zip":25,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Hospital del Niño Sor Teresa Huarte Tama","RECRUITING","Sucre","Chuquisaca Department","Bolivia","BO",{"type":75,"coordinates":76},"Point",[77,78],-65.26274,-19.03332,{"lat":78,"lon":77},[81],{"name":82,"role":59,"phone":83,"phoneExt":25,"email":84},"Jhovana Elizabeth Paco Barral, MD","+59165707332","jpacobarral@gmail.com",{"facility":86,"status":69,"city":87,"state":88,"zip":25,"country":72,"countryCode":73,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Hospital del Norte - El Alto","La Paz","La Paz Department",{"type":75,"coordinates":90},[91,92],-68.15,-16.5,{"lat":92,"lon":91},[95],{"name":96,"role":59,"phone":97,"phoneExt":25,"email":98},"Ingrid Dávalos, MD","+59175411754","narelita.dz@hotmail.com",{"facility":100,"status":69,"city":101,"state":102,"zip":25,"country":72,"countryCode":73,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Hospital Daniel Brancamonte","Potosí","Potosí Department",{"type":75,"coordinates":104},[105,106],-65.75306,-19.58361,{"lat":106,"lon":105},[109],{"name":110,"role":59,"phone":111,"phoneExt":25,"email":112},"Milenka Gamboa, MD","+59172416966","milicita@yahoo.com",{"facility":114,"status":69,"city":115,"state":116,"zip":25,"country":72,"countryCode":73,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"Hospital Regional San Juan de Dios","Tarija","Tarija Department",{"type":75,"coordinates":118},[119,120],-64.72956,-21.53549,{"lat":120,"lon":119},[123],{"name":124,"role":59,"phone":125,"phoneExt":25,"email":126},"Nils Casson, MD","+59176187393","nilsjefe1@hotmail.com",{"facility":128,"status":69,"city":129,"state":25,"zip":25,"country":130,"countryCode":131,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Clinica Indisa","Santiago","Chile","CL",{"type":75,"coordinates":133},[134,135],-70.64827,-33.45694,{"lat":135,"lon":134},[138],{"name":139,"role":59,"phone":140,"phoneExt":25,"email":141},"Victor Monreal, MD","+5693373202","victor.monreal@indisa.cl",{"facility":143,"status":69,"city":144,"state":145,"zip":146,"country":147,"countryCode":148,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Hospital Universitario Clinica San Rafael","Bogotá","DC","110411","Colombia","CO",{"type":75,"coordinates":150},[151,152],-74.08175,4.60971,{"lat":152,"lon":151},[155],{"name":156,"role":59,"phone":157,"phoneExt":25,"email":158},"Jennifer Morantes, MD","+573007763472","jennmorantes@gmail.com",{"facility":160,"status":69,"city":144,"state":145,"zip":161,"country":147,"countryCode":148,"cosmosGeoPoint":162,"geoPoint":164,"contacts":165},"Sociedad de Cirugia de Bogota Hospital de San Jose","110421",{"type":75,"coordinates":163},[151,152],{"lat":152,"lon":151},[166],{"name":167,"role":59,"phone":168,"phoneExt":25,"email":169},"Pablo Vasquez Hoyos, MD, MSc","57318717-2029","pvasquez@fucsalud.edu.co",{"facility":171,"status":69,"city":144,"state":145,"zip":172,"country":147,"countryCode":148,"cosmosGeoPoint":173,"geoPoint":175,"contacts":176},"Fundación HOMI","111411",{"type":75,"coordinates":174},[151,152],{"lat":152,"lon":151},[177],{"name":178,"role":59,"phone":179,"phoneExt":25,"email":180},"Diana Escobar, MD","+573147045321","dpescobars@unal.edu.co",{"facility":182,"status":69,"city":144,"state":145,"zip":25,"country":147,"countryCode":148,"cosmosGeoPoint":183,"geoPoint":185,"contacts":186},"Hospital Militar Central de Bogotá",{"type":75,"coordinates":184},[151,152],{"lat":152,"lon":151},[187],{"name":188,"role":59,"phone":189,"phoneExt":25,"email":190},"Ledys Izquierdo, MD","+573124819193","lizquierdo@homil.gov.co",{"facility":192,"status":69,"city":144,"state":145,"zip":25,"country":147,"countryCode":148,"cosmosGeoPoint":193,"geoPoint":195,"contacts":196},"Hospital Santa Clara",{"type":75,"coordinates":194},[151,152],{"lat":152,"lon":151},[197],{"name":188,"role":59,"phone":189,"phoneExt":25,"email":198},"lizquierdo@unal.edu.co",{"facility":200,"status":69,"city":144,"state":145,"zip":25,"country":147,"countryCode":148,"cosmosGeoPoint":201,"geoPoint":203,"contacts":204},"Hospital Universitario San Ignacio",{"type":75,"coordinates":202},[151,152],{"lat":152,"lon":151},[205],{"name":206,"role":59,"phone":25,"phoneExt":25,"email":207},"Deyanira Quiñones, MD","adquinonez@husi.org.co",{"facility":209,"status":69,"city":144,"state":145,"zip":25,"country":147,"countryCode":148,"cosmosGeoPoint":210,"geoPoint":212,"contacts":213},"Los Cobos Medical Center",{"type":75,"coordinates":211},[151,152],{"lat":152,"lon":151},[214],{"name":215,"role":59,"phone":216,"phoneExt":25,"email":217},"Andrea Rodríguez Mayorga, MD","+573142128477","andrerodriguezmayorga@gmail.com",{"facility":219,"status":69,"city":220,"state":221,"zip":222,"country":147,"countryCode":148,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Fundacion Hospital Infantil Los Angeles","Pasto","Departamento de Nariño","520002",{"type":75,"coordinates":224},[225,226],-77.27846,1.21456,{"lat":226,"lon":225},[229],{"name":230,"role":59,"phone":25,"phoneExt":25,"email":231},"Liliana Mazzillo, MD","lilianamazzillo@gmail.com",{"facility":233,"status":69,"city":234,"state":235,"zip":236,"country":147,"countryCode":148,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"Clínica UROS S.A","Neiva","Huila Department","410010",{"type":75,"coordinates":238},[239,240],-75.27973,2.93001,{"lat":240,"lon":239},[243],{"name":244,"role":59,"phone":245,"phoneExt":25,"email":246},"Ivan Ardila, MD","+573174301866","ivanjoardila@hotmail.com",{"facility":248,"status":249,"city":250,"state":251,"zip":25,"country":147,"countryCode":148,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"Fundación Valle de Lili","NOT_YET_RECRUITING","Cali","Valle del Cauca Department",{"type":75,"coordinates":253},[254,255],-76.5199,3.43054,{"lat":255,"lon":254},[258],{"name":259,"role":59,"phone":260,"phoneExt":25,"email":261},"Ruben Lasso, MD","+573008200144","rubenlasso@gmail.com",{"facility":263,"status":249,"city":144,"state":25,"zip":264,"country":147,"countryCode":148,"cosmosGeoPoint":265,"geoPoint":267,"contacts":268},"LaCardio","110131",{"type":75,"coordinates":266},[151,152],{"lat":152,"lon":151},[269],{"name":270,"role":59,"phone":271,"phoneExt":25,"email":272},"Jaime Fernandez Sarmiento, MD, PHD","+573103249002","jaimefe@unisabana.edu.co",{"facility":274,"status":69,"city":275,"state":276,"zip":25,"country":277,"countryCode":278,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"Hospital de Emergencias Pediatricas","Lima","Lima Province","Peru","PE",{"type":75,"coordinates":280},[281,282],-77.02824,-12.04318,{"lat":282,"lon":281},[285],{"name":286,"role":59,"phone":287,"phoneExt":25,"email":288},"Yhuri Carreazo, MD","+51997252543","yhuroc@gmail.com",{"facility":290,"status":69,"city":291,"state":25,"zip":25,"country":277,"countryCode":278,"cosmosGeoPoint":292,"geoPoint":296,"contacts":297},"Hospital Nacional Adolfo Guevara Velasco","Cusco",{"type":75,"coordinates":293},[294,295],-71.96701,-13.53188,{"lat":295,"lon":294},[298],{"name":299,"role":59,"phone":300,"phoneExt":25,"email":301},"Yesica Luna, MD","+51992818282","yesilunde@hotmail.com",{"facility":303,"status":69,"city":304,"state":305,"zip":306,"country":307,"countryCode":308,"cosmosGeoPoint":309,"geoPoint":313,"contacts":314},"Centro Hospitalario Pereira Rossell","Montevideo","Montevideo Department","11600","Uruguay","UY",{"type":75,"coordinates":310},[311,312],-56.18816,-34.90328,{"lat":312,"lon":311},[315],{"name":63,"role":59,"phone":316,"phoneExt":25,"email":65},"+5759899585225",{"facility":318,"status":69,"city":304,"state":25,"zip":25,"country":307,"countryCode":308,"cosmosGeoPoint":319,"geoPoint":321,"contacts":322},"Círculo Católico",{"type":75,"coordinates":320},[311,312],{"lat":312,"lon":311},[323],{"name":324,"role":59,"phone":325,"phoneExt":25,"email":326},"Mónica Decia, MD","+59899664031","monicadecia@gmail.com",{"type":328,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[330,332],{"name":331,"class":6},"Universidad Nacional de Colombia",{"name":333,"class":6},"Fundación Universitaria de Ciencias de la Salud","100607839","altitude-and-outcomes-in-pediatric-ards-a-multicenter-study-100607839",false,"NCT07193771","Altitude and Outcomes in Pediatric ARDS: A Multicenter Study","Evaluation of Altitude as an Independent Risk Factor for Mortality in Pediatric Acute Respiratory Distress Syndrome: Influence of Oxygenation, Ventilation, and Hospital Structure in a Multicenter Observational Study.","LARed-ALT","Inclusion Criteria:\n\n* Age between 1 month (corrected gestational age) and 18 years.\n* Admission to a pediatric intensive care unit (PICU) or facility where mechanically ventilated children are cared for.\n* Requirement of invasive mechanical ventilation.\n* Diagnosis of pediatric acute respiratory distress syndrome (PARDS) according to PALICC criteria, confirmed within 24 hours before or after endotracheal intubation.\n\nExclusion Criteria:\n\n* Patients with active perinatal lung disease (e.g., neonatal respiratory distress syndrome, pulmonary hemorrhage, persistent pulmonary hypertension of the newborn, early bronchopulmonary dysplasia, meconium aspiration).\n* Patients who have received extracorporeal membrane oxygenation (ECMO) prior to or within the first 24 hours of PARDS diagnosis.\n* Patients with pre-established limitation of therapeutic effort (LTE) orders or palliative care directives documented before the initiation of invasive mechanical ventilation.\n* Readmissions to the PICU during the study period (only the first episode per patient will be included).","ALL","1 Month","18 Years",{"count":346,"type":347},1600,"ESTIMATED","OBSERVATIONAL","This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome (PARDS). Data on demographics, physiology, and hospital structure will be collected from PICUs located at different altitudes worldwide. The study aims to identify gaps in PARDS management and provide recommendations adapted to diverse resource settings.",[351,352,353],"Respiratory Distress Syndrome, Pediatric","Altitude Hypoxia","High Altitude Effects","2026-05-29",{"date":356,"type":357},"2026-06-02","ACTUAL",{"date":359,"type":357},"2025-11-01",{"date":361,"type":347},"2028-03",{"name":5,"class":6},20]