[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653091":3},{"organization":4,"outcomesModule":7,"designInfo":39,"detailedDescription":38,"studyPopulation":38,"armGroups":45,"interventions":67,"overallOfficials":38,"centralContacts":80,"locations":87,"responsibleParty":104,"collaborators":38,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":38,"eligibilityCriteria":114,"healthyVolunteers":115,"sex":116,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":38,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":132,"overallStatus":89,"whyStopped":38,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":147},{"fullName":5,"class":6},"University of Ottawa","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":38},[9],{"measure":10,"description":11,"timeFrame":12},"Core temperature","Core temperature indexed by visceral (telemetry pill) temperature","End of each of the four 15 minutes exercise bouts (average of last 5 minutes)",[14,17,20,23,27,30,32,35],{"measure":15,"description":16,"timeFrame":12},"Evaporative heat loss","Evaporative heat loss as assessed using a direct air calorimeter",{"measure":18,"description":19,"timeFrame":12},"Dry heat loss","Dry heat loss as assessed using a direct air calorimeter",{"measure":21,"description":22,"timeFrame":12},"Whole-body total heat loss","Total heat loss (evaporative + dry) as assessed using a direct air calorimeter",{"measure":24,"description":25,"timeFrame":26},"Body heat storage","Heat stored in the body for each of the exercise bouts","Change from start to end of exercise for each of the four 15 minutes exercise bouts",{"measure":28,"description":29,"timeFrame":12},"Skin temperature","Skin temperature measured at 8-sites (forehead, chest, scapula, upper arm, forearm, hand, thigh, calf) with mean value calculated as weighted values of 8 sites - forehead 7%, chest 17.5%, scapula 17.5%, upper arm 7%, forearm 7%, hand 5%, thigh 19%, and calf 20%.",{"measure":31,"description":29,"timeFrame":12},"Change in skin temperature",{"measure":33,"description":34,"timeFrame":12},"Heart rate","Heart rate measured continuously with chest-band telemetric device",{"measure":36,"description":37,"timeFrame":12},"Thermal sensation","Thermal sensation will be assessed using the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) 7-point scale (\"0=neutral to 7=extremely hot\")",null,{"allocation":40,"interventionModel":41,"interventionModelDescription":38,"primaryPurpose":42,"observationalModel":38,"timePerspective":38,"maskingInfo":43},"RANDOMIZED","CROSSOVER","BASIC_SCIENCE",{"masking":44,"maskingDescription":38,"whoMasked":38},"NONE",[46,52,57,62],{"label":47,"type":48,"description":49,"interventionNames":50},"Exercise at 22°C","EXPERIMENTAL","Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 22°C (celsius; 72°F, fahrenheit). Exercise will be performed at a metabolic heat production of 160 W\u002Fm² (W = watts, m = meters) and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.",[51],"Other: Exercise at 22°C",{"label":53,"type":48,"description":54,"interventionNames":55},"Exercise at 26°C","Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 26°C (79°F). Exercise will be performed at a metabolic heat production of 160 W\u002Fm² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.",[56],"Other: Exercise at 26°C",{"label":58,"type":48,"description":59,"interventionNames":60},"Exercise at 31°C","Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 31°C (88°F). Exercise will be performed at a metabolic heat production of 160 W\u002Fm² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.",[61],"Other: Exercise at 31°C",{"label":63,"type":48,"description":64,"interventionNames":65},"Exercise at 36°C","Participants will complete intermittent moderate-intensity exercise at an ambient temperature of 36°C (97°F). Exercise will be performed at a metabolic heat production of 160 W\u002Fm² and will consist of four 15-minute exercise periods separated by 15-minute rest periods. Exercise workload will be individually adjusted to achieve the prescribed metabolic heat production.",[66],"Other: Exercise at 36°C",[68,71,74,77],{"type":6,"name":47,"description":69,"armGroupLabels":70,"otherNames":38},"Participants complete intermittent exercise at a metabolic heat production of 160 W\u002Fm² in an ambient temperature of 22°C (72°F).",[47],{"type":6,"name":53,"description":72,"armGroupLabels":73,"otherNames":38},"Participants complete intermittent exercise at a metabolic heat production of 160 W\u002Fm² in an ambient temperature of 26°C (79°F).",[53],{"type":6,"name":58,"description":75,"armGroupLabels":76,"otherNames":38},"Participants complete intermittent exercise at a metabolic heat production of 160 W\u002Fm² in an ambient temperature of 31°C (88°F).",[58],{"type":6,"name":63,"description":78,"armGroupLabels":79,"otherNames":38},"Participants complete intermittent exercise at a metabolic heat production of 160 W\u002Fm² in an ambient temperature of 36°C (97°F).",[63],[81],{"name":82,"role":83,"phone":84,"phoneExt":85,"email":86},"Glen P Kenny, PhD","CONTACT","6135625800","4282","gkenny@uottawa.ca",[88],{"facility":5,"status":89,"city":90,"state":91,"zip":92,"country":93,"countryCode":94,"cosmosGeoPoint":95,"geoPoint":100,"contacts":101},"RECRUITING","Ottawa","Ontario","K1N 6N5","Canada","CA",{"type":96,"coordinates":97},"Point",[98,99],-75.69812,45.41117,{"lat":99,"lon":98},[102],{"name":82,"role":83,"phone":103,"phoneExt":85,"email":86},"613-562-5800",{"type":105,"investigatorFullName":106,"investigatorTitle":107,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"PRINCIPAL_INVESTIGATOR","Glen P. Kenny","Full Professor","100653091","ambient-temperature-and-thermoregulation-during-exercise-in-children-and-youth-100653091",false,"NCT07781605","Ambient Temperature and Thermoregulation During Exercise in Children and Youth","Ambient Temperature and Thermoregulation During Moderate-Intensity Exercise in Children and Youth","Inclusion Criteria:\n\n* Healthy male or female.\n* Aged 9-16 years or 20-25 years.\n* Habitually active, defined as participating in regular physical activity at least 3 times per week for at least 20 minutes per session over the previous 6 months.\n* Able to understand and communicate in English or French.\n* For participants younger than 18 years, written parental or guardian consent and participant assent are required.\n\nExclusion Criteria:\n\n* Acute illness at the time of testing (e.g., cold, flu, or infection).\n* History of a chronic medical condition that may affect thermoregulation, cardiovascular function, or exercise capacity (e.g., cardiovascular disease, metabolic disorders, respiratory disease including asthma requiring regular medication, or neurological disorders).\n* Use of medications known to affect thermoregulation, hydration status, or cardiovascular responses.\n* History of heat-related illness (e.g., heat exhaustion or heat stroke).\n* Digestive abnormalities or gastrointestinal conditions that may contraindicate ingestion of a telemetry pill.\n* Any condition that, in the opinion of the investigators, would compromise participant safety or the integrity of the data.",true,"ALL","9 Years","25 Years",{"count":120,"type":121},12,"ESTIMATED","INTERVENTIONAL",[124],"NA","Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute to their responses. The goal of this clinical trial is to determine how ambient temperature affects thermoregulation during exercise in boys and girls aged 9-16 years compared with young adult men and women aged 20-25 years. Participants will complete four study visits at ambient temperatures of 22°C (Celsius; 72°F, Fahrenheit), 26°C (79°F), 31°C (88°F), and 36°C (97°F), while exercising at the same moderate-intensity metabolic heat production of 160 W\u002Fm² (W = watts, m = meters). During each visit, participants will complete four 15-minute periods of exercise (exercise bouts 1, 2, 3 and 4 respectively) separated by 15-minute rest periods. Testing will be performed in a whole-body air calorimeter, a specialized chamber that precisely measures heat lost through evaporation and dry heat exchange and the amount of heat stored in the body. These measurements, together with core temperature and heart rate, will allow researchers to determine how increasing ambient temperature affects the body's ability to lose heat and whether these responses differ between children and youth and young adults.",[127,128,129,130,131],"Body Temperature Changes","Heat Stress","Child Development","Heat","Physiological Stress",[133,134,135,136,137],"Thermoregulation","Heat loss","Heat tolerance","Heat strain","Physical activity","2026-08-20",{"date":140,"type":141},"2026-08-24","ACTUAL",{"date":143,"type":141},"2026-07-19",{"date":145,"type":121},"2027-06-30",{"name":5,"class":6},1]