[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100367385":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":33,"responsibleParty":79,"collaborators":82,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":20,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":20,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":53,"whyStopped":20,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Subjects undergoing the proposed operative intervention. Intervention patients will serve as their own control for all outcome measures",[13],"Procedure: Residual limb revision",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Residual limb revision","Surgical procedure involving construction of agonist-antagonist myoneural interfaces (AMIs)",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Matthew J Carty, MD","PRINCIPAL_INVESTIGATOR",[26,30],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","6179834555","mcarty@partners.org",{"name":31,"role":27,"phone":20,"phoneExt":20,"email":32},"Research Coordinators","limbrestoration@bwh.harvard.edu",[34,52,65],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Walter Reed National Military Medical Center","NOT_YET_RECRUITING","Bethesda","Maryland","20889","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-77.10026,38.98067,{"lat":46,"lon":45},[49],{"name":50,"role":27,"phone":20,"phoneExt":20,"email":51},"Kyle Potter, MD","benjamin.k.potter.mil@mail.mil",{"facility":5,"status":53,"city":54,"state":55,"zip":56,"country":40,"countryCode":41,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"RECRUITING","Boston","Massachusetts","02115",{"type":43,"coordinates":58},[59,60],-71.05977,42.35843,{"lat":60,"lon":59},[63],{"name":23,"role":27,"phone":64,"phoneExt":20,"email":29},"617-983-4555",{"facility":66,"status":53,"city":67,"state":55,"zip":68,"country":40,"countryCode":41,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Massachusetts Institute of Technology","Cambridge","02139",{"type":43,"coordinates":70},[71,72],-71.10561,42.3751,{"lat":72,"lon":71},[75],{"name":76,"role":27,"phone":77,"phoneExt":20,"email":78},"Hugh Herr, PhD","617-314-3661","hherr@media.mit.edu",{"type":24,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Matthew Carty","Principal Investigator",[83],{"name":66,"class":6},"100367385","ami-construction-in-lower-extremity-residual-limbs-100367385",false,"NCT04063592","AMI Construction in Lower Extremity Residual Limbs","A Novel Approach to Lower Extremity Residual Limb Revision to Augment Volitional Motor Control, Restore Proprioception and Reverse Limb Atrophy","Inclusion Criteria:\n\n* Between the ages of 18-65\n* Has already undergone a standard AKA or BKA procedure\n* Suffers from symptoms such as:\n\n  * Intractable pain\n  * Deterioration of skin on or around stump\n  * Suffering from other sources of discomfort arising from stump\n* Intact inherent wound healing\n* Adequate communication skills\n* High motivation\n\nExclusion Criteria:\n\n* Inadequate health to undergo operative procedure using standard anesthesia (i.e. cardiopulmonary)\n* Individuals with impaired wound healing\n* Individuals suffering from extensive peripheral neuropathies\n* Active smokers\n* Individuals with a history of poor compliance\n* Women who are pregnant or plan to become pregnant before surgical intervention",true,"ALL","18 Years","65 Years",{"count":96,"type":97},26,"ESTIMATED","INTERVENTIONAL",[100],"NA","This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy",[103],"Amputation",[103,105,106,107,108],"Residual limb pain","Phantom pain","Residual limb atrophy","Prosthesis control","2026-07-07",{"date":111,"type":112},"2026-07-09","ACTUAL",{"date":114,"type":112},"2020-02-24",{"date":116,"type":97},"2026-09-30",{"name":5,"class":6},3]