[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100659357":3},{"organization":4,"outcomesModule":7,"designInfo":71,"detailedDescription":79,"studyPopulation":76,"armGroups":80,"interventions":87,"overallOfficials":92,"centralContacts":96,"locations":104,"responsibleParty":120,"collaborators":76,"id":123,"slug":124,"hasResults":125,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":76,"eligibilityCriteria":128,"healthyVolunteers":125,"sex":129,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":76,"studyType":135,"phases":136,"briefSummary":137,"conditions":138,"keywords":144,"overallStatus":147,"whyStopped":76,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":26,"otherOutcomes":62},[9,13,16,19,23],{"measure":10,"description":11,"timeFrame":12},"PTSD Checklist for DSM-5","PCL-5","Week -2, week -1, week 0, weeks 1-12, week 24, week 36",{"measure":14,"description":15,"timeFrame":12},"Social Functioning Questionnaire","SFQ; measure of functioning\u002Fimpairment",{"measure":17,"description":18,"timeFrame":12},"Post-Traumatic Cognitions Inventory-9","PTCI-9; brief measure of beliefs about the self, others, and the world",{"measure":20,"description":21,"timeFrame":22},"Clinician-Administered PTSD Scale for DSM-5","CAPS-5; clinician-administered measure of post-traumatic stress disorder symptoms","Weeks -2, 12",{"measure":24,"description":25,"timeFrame":22},"Post-Traumatic Growth Inventory-10","PTGI-10",[27,31,35,38,41,45,48,52,56,59],{"measure":28,"description":29,"timeFrame":30},"Generalized Anxiety Disorder-7","GAD-7; measure of generalized anxiety symptoms","Screening\u002Fweek -2; week 12",{"measure":32,"description":33,"timeFrame":34},"Generalized Anxiety Disorder-2","GAD-2; brief measure of generalized anxiety symptoms","Weeks 1-12, 24, and 36",{"measure":36,"description":37,"timeFrame":30},"Patient Health Questionnaire-9","PHQ-9; measure of depressive symptoms",{"measure":39,"description":40,"timeFrame":34},"Patient Health Questionnaire-2","PHQ-2; brief measure of depressive symptoms",{"measure":42,"description":43,"timeFrame":44},"Inventory of Interpersonal Problems-32","IIP-32; measure of interpersonal problems","Weeks -2, 12, 24, 36",{"measure":46,"description":47,"timeFrame":22},"Experiences in Close Relationships-Short Form","ECR-SF; brief measure of attachment anxiety and avoidance",{"measure":49,"description":50,"timeFrame":51},"Experiential Avoidance Rating Scale","EARS; brief measure of experiential avoidance","Week -2, weeks 1-12",{"measure":53,"description":54,"timeFrame":55},"Cognitive Fusion Questionnaire","CFQ; brief measure of cognitive fusion","Week -2, Weeks 1-12",{"measure":57,"description":58,"timeFrame":22},"Difficulty in Emotion Regulation Scale-16","DERS-16",{"measure":60,"description":61,"timeFrame":22},"Therapeutic Reactance Scale","TRS",[63,67],{"measure":64,"description":65,"timeFrame":66},"Credibility\u002FExpectancy of Therapy","CEQ; measure of participant's expectations about the intervention","Week -2",{"measure":68,"description":69,"timeFrame":70},"Agnew Relationship Measure-5","ARM-5; brief measure of therapeutic alliance","Weeks 2-12",{"allocation":72,"interventionModel":73,"interventionModelDescription":74,"primaryPurpose":75,"observationalModel":76,"timePerspective":76,"maskingInfo":77},"NA","SINGLE_GROUP","Interrupted time-series model with three pre-intervention baseline assessment points.","TREATMENT",null,{"masking":78,"maskingDescription":76,"whoMasked":76},"NONE","We are using an interrupted time-series design with multiple baseline measurements to assess the effectiveness of a 12-session LGBTQ-affirming cognitive processing therapy (CPT) intervention for post-traumatic stress and associated outcomes related to interpersonal (e.g., sexual assault, intimate partner violence) and developmental (e.g., child physical\u002Fsexual\u002Femotional abuse\u002Fneglect).",[81],{"label":82,"type":83,"description":84,"interventionNames":85},"Cognitive Processing Therapy","EXPERIMENTAL","Standard, manualized 12-session cognitive processing therapy",[86],"Behavioral: Cognitive Processing Therapy",[88],{"type":89,"name":82,"description":90,"armGroupLabels":91,"otherNames":76},"BEHAVIORAL","n\u002Fa; this is the only intervention within the study",[82],[93],{"name":94,"affiliation":5,"role":95},"Nicholas C Borgogna, PhD","PRINCIPAL_INVESTIGATOR",[97,101],{"name":94,"role":98,"phone":99,"phoneExt":76,"email":100},"CONTACT","(205) 934-3850","borgogna@uab.edu",{"name":102,"role":98,"phone":76,"phoneExt":76,"email":103},"Drew Whittington, MS, MA","whitdrew@uab.edu",[105],{"facility":5,"status":76,"city":106,"state":107,"zip":108,"country":109,"countryCode":110,"cosmosGeoPoint":111,"geoPoint":116,"contacts":117},"Birmingham","Alabama","35233","United States","US",{"type":112,"coordinates":113},"Point",[114,115],-86.80249,33.52066,{"lat":115,"lon":114},[118],{"name":119,"role":98,"phone":99,"phoneExt":76,"email":100},"Nicholas Borgogna, PhD",{"type":95,"investigatorFullName":121,"investigatorTitle":122,"investigatorAffiliation":5,"oldNameTitle":76,"oldOrganization":76},"Nicholas C. Borgogna","Assistant Professor","100659357","an-interrupted-time-series-pilot-trial-of-lgbtq-affirming-cognitive-processing-therapy-for-interpersonal-and-developmental-trauma-100659357",false,"NCT07863817","An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma","Inclusion Criteria:\n\n* LGBTQ+-identifying\n* PCL-5 score ≥ 30 (clinically significant PTSD symptoms) OR verifiable PTSD diagnosis based on CAPS interview\n* 18 years or older\n* Documented interpersonal or developmental trauma (e.g., a history of childhood physical, emotional, or sexual abuse; sexual assault; or intimate partner violence)\n* English-speaking\n\nExclusion Criteria:\n\n* Prior 12-month history of non substance-induced psychosis or mania\n* Non-suicidal self-injury within three months prior to screening\n* Suicide attempt within 12 months prior to screening\n* Illicit substance use within 7 days prior to screening\n* Active diagnosis of anorexia nervosa or bulimia nervosa\n* Active plan for suicide within one month prior to screening","ALL","18 Years","85 Years",{"count":133,"type":134},25,"ESTIMATED","INTERVENTIONAL",[72],"We are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults. This study requires in-person participation weekly at the UAB campus in Birmingham, AL.",[139,140,141,142,143],"Post-Traumatic Stress Disorder, Chronic","Depressed Mood","Depressive and Anxiety Disorders","Anxiety","Depression - Major Depressive Disorder",[145,146],"cognitive processing therapy","LGBTQ","NOT_YET_RECRUITING","2026-10-02",{"date":150,"type":151},"2026-10-07","ACTUAL",{"date":153,"type":134},"2027-01",{"date":155,"type":134},"2028-12",{"name":5,"class":6},1]