[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645392":3},{"organization":4,"outcomesModule":7,"designInfo":20,"detailedDescription":23,"studyPopulation":24,"armGroups":25,"interventions":31,"overallOfficials":36,"centralContacts":43,"locations":53,"responsibleParty":71,"collaborators":11,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":11,"studyType":87,"phases":11,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":56,"whyStopped":11,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Fakih IVF Fertility Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"Concentration of serum 25-hydroxyvitamin D levels measured on the day of FET",null,"Vitamin D level tested on the day of FET.",{"measure":14,"description":11,"timeFrame":15},"Clinical pregnancy test","From enrollment on day of FET to 1 month post FET",[17],{"measure":18,"description":11,"timeFrame":19},"Live birth rate, miscarriage rate, and preterm birth rate.","From enrollment to six weeks post partum",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":21,"timePerspective":22,"maskingInfo":11},"COHORT","PROSPECTIVE","Serum vitamin D3 has attracted growing research interest for its potential role in female reproductive physiology. While some studies associate sufficient vitamin D3 levels with improved IVF outcomes, others have failed to confirm this, leaving the evidence base contested. Despite this uncertainty, pre-In vitro fertilization (IVF) vitamin D screening and supplementation of insufficient patients has become widespread clinical practice. Evidence specific to frozen embryo transfer (FET) cycles remains particularly limited. Recent prospective studies found no significant difference in ongoing pregnancy, live birth, or implantation rates between vitamin D3-insufficient women receiving supplementation and vitamin D3-replete women who did not, underscoring the need for higher-quality, targeted research. While emerging data support a role for vitamin D in endometrial receptivity, it remains unclear whether correcting insufficiency prior to FET meaningfully improves reproductive success.\n\nTo address these gaps, our study will evaluate the association between serum vitamin D3 levels on the day of FET and subsequent pregnancy and delivery outcomes at a UAE fertility center. Supplementation history and relevant clinical variables will be captured via patient questionnaire. Vitamin D status will be classified per International Society of Endocrinology guidance: deficient (\\\u003C20 ng\u002FmL), insufficient (20-29 ng\u002FmL), and sufficient (≥30 ng\u002FmL). Given the high regional prevalence of vitamin D deficiency, this study is well-positioned to determine whether vitamin D status represents a modifiable determinant of reproductive success, with direct implications for clinical screening and management protocols in this population.","Women undergoing FET cycle who do not suffer from conditions affecting implantation and have got vitamin D levels tested 3 - 6 months before FET cycle.",[26],{"label":27,"type":11,"description":28,"interventionNames":29},"Women undergoing frozen embryo transfer (FET) at Fakih IVF","The study will enroll women aged 18-40 years with a BMI of 18-40 kg\u002Fm² undergoing FET at Fakih IVF, who had serum vitamin D assessed within three months prior to transfer. Women with deficient levels (\\\u003C30 ng\u002FmL) must have received supplementation prior to FET to be eligible.\n\nExclusions are designed to reduce confounding: women are excluded if vitamin D was not measured within the required window, if identified deficiency went untreated, or if they have a history of recurrent implantation failure (RIF). Women with uterine factors known to impair implantation including congenital anomalies, intrauterine adhesions, or submucosal fibroids are also excluded, as are those with significant medical comorbidities that may independently affect pregnancy outcomes.",[30],"Other: No Intervention: Observational Cohort",[32],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":11},"No Intervention: Observational Cohort","There are no interventions in this study. This is an observational cohort study.",[27],[37,41],{"name":38,"affiliation":39,"role":40},"Lamiya Mohiyiddeen, MD, FRCOG","Fakih IVF Abu Dhabi","PRINCIPAL_INVESTIGATOR",{"name":42,"affiliation":39,"role":40},"Michael Fakih, MD",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":11,"email":48},"Dr. Lamiya Mohiyiddeen, MD, FRCOG","CONTACT","+971543676002","lamiya.mohiyiddeen@fakihivf.com",{"name":50,"role":46,"phone":51,"phoneExt":11,"email":52},"Fatma Bathawab, PhD","+971585707393","fatma.bathawab@fakihivf.com",[54],{"facility":55,"status":56,"city":57,"state":11,"zip":11,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Fakih IVF Fertility Centre LLC","RECRUITING","Abu Dhabi","United Arab Emirates","AE",{"type":61,"coordinates":62},"Point",[63,64],54.39696,24.45118,{"lat":64,"lon":63},[67,68,69,70],{"name":45,"role":46,"phone":47,"phoneExt":11,"email":48},{"name":50,"role":46,"phone":51,"phoneExt":11,"email":52},{"name":42,"role":40,"phone":11,"phoneExt":11,"email":11},{"name":38,"role":40,"phone":11,"phoneExt":11,"email":11},{"type":72,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100645392","an-investigation-of-the-effect-of-vitamin-d-level-during-frozen-embryo-transfer-fet-in-ivf-and-pregnancy-outcomes-100645392",false,"NCT07681115","An Investigation of the Effect of Vitamin D Level During Frozen Embryo Transfer (FET) in IVF and Pregnancy Outcomes","Vitamin D Levels and Pregnancy Outcomes Following Frozen Embryo Transfer (FET) in the UAE","VitD in FET","Inclusion:\n\n* Women undergoing frozen embryo transfer (FET) at Fakih IVF.\n* Age between 18 and 40 years.\n* Body mass index (BMI) between 18 and 40 kg\u002Fm².\n* Patients who had serum vitamin D levels assessed within three months prior to FET\n* Supplementation with Vitamin D if deficient \\\u003C 30 ng\u002FmL (75 nmol\u002FL).\n\nExclusion:\n\n* Age below 18 years or above 40 years.\n* BMI below 18 kg\u002Fm² or above 40 kg\u002Fm².\n* Patients who did not have vitamin D levels measured within three months prior to FET.\n* Patients who were found to have low vitamin D levels but did not receive supplementation.\n* Patients with recurrent implantation failure (RIF).\n* Patients with known uterine factors affecting implantation (e.g., congenital uterine anomalies, intrauterine adhesions, submucosal fibroids).\n* Patients with significant medical comorbidities that may affect pregnancy outcomes.","FEMALE","18 Years","40 Years",{"count":85,"type":86},126,"ESTIMATED","OBSERVATIONAL","Vitamin D is best known for keeping our bones healthy, but growing research suggests it may also play a role in fertility. Many In vitro fertilization (IVF) clinics now routinely check vitamin D levels and prescribe supplements before treatment, but the science is still unclear on whether this actually improves the chances of pregnancy.\n\nOur study, based in the United Arab Emirates (UAE), aims to find out whether a woman's vitamin D level on the day of her frozen embryo transfer (FET) makes a difference to whether she becomes pregnant and delivers a baby. The UAE is an ideal setting for this research, as vitamin D deficiency is particularly common in the region. The findings could shape how fertility clinics screen and treat women seeking fertility treatment in the future.",[90,91],"Vitamin D Insufficiency","In Vitro Fertilization and Embryo Transfer",[93,94],"frozen embryo transfer cycle","Vitamin D","2026-07-13",{"date":97,"type":98},"2026-07-15","ACTUAL",{"date":100,"type":98},"2026-06-01",{"date":102,"type":86},"2027-08",{"name":5,"class":6},1]