[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640438":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":39,"locations":44,"responsibleParty":177,"collaborators":29,"id":179,"slug":180,"hasResults":181,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":29,"eligibilityCriteria":185,"healthyVolunteers":181,"sex":186,"minAge":187,"maxAge":29,"enrollmentInfo":188,"targetDuration":29,"studyType":191,"phases":192,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":47,"whyStopped":29,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":208},{"fullName":5,"class":6},"BeOne Medicines","INDUSTRY",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 1a: Part A: Dose escalation, BG-75202 monotherapy","EXPERIMENTAL","Sequential cohorts of increasing dose levels of BG-75202 will be evaluated as monotherapy.",[13],"Drug: BG-75202",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase 1a: Part B: Dose escalation, BG-75202 + Hypomethylation Agent (HMA)","Sequential cohorts of increasing dose levels of BG-75202 in combination with Hypomethylation Agent (HMA) will be evaluated.",[13,18],"Drug: Hypomethylation Agent (HMA)",{"label":20,"type":10,"description":21,"interventionNames":22},"Phase 1b: Dose optimization, BG-75202 monotherapy","Participants will receive BG-75202 monotherapy",[13],[24,30],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","BG-75202","Administered orally",[9,15,20],null,{"type":25,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"Hypomethylation Agent (HMA)","Administered Intravenous (IV) or Subcutaneous (SC)",[15],[35],{"name":36,"affiliation":37,"role":38},"Study Director","BeOne 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University","Guangzhou","Guangdong","510000",{"type":54,"coordinates":106},[107,108],113.25,23.11667,{"lat":108,"lon":107},{"facility":111,"status":47,"city":112,"state":113,"zip":114,"country":93,"countryCode":94,"cosmosGeoPoint":115,"geoPoint":119,"contacts":29},"The Second Hospital of Hebei Medical University","Shijiazhuang","Hebei","050000",{"type":54,"coordinates":116},[117,118],114.47861,38.04139,{"lat":118,"lon":117},{"facility":121,"status":47,"city":122,"state":123,"zip":124,"country":93,"countryCode":94,"cosmosGeoPoint":125,"geoPoint":129,"contacts":29},"Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology","Wuhan","Hubei","430030",{"type":54,"coordinates":126},[127,128],114.26667,30.58333,{"lat":128,"lon":127},{"facility":131,"status":47,"city":132,"state":133,"zip":134,"country":93,"countryCode":94,"cosmosGeoPoint":135,"geoPoint":139,"contacts":29},"The First Affiliated Hospital of Soochow University","Suzhou","Jiangsu","215006",{"type":54,"coordinates":136},[137,138],120.59538,31.30408,{"lat":138,"lon":137},{"facility":141,"status":47,"city":142,"state":143,"zip":144,"country":93,"countryCode":94,"cosmosGeoPoint":145,"geoPoint":149,"contacts":29},"The First Affiliated Hospital of Nanchang University Branch Donghu","Nanchang","Jiangxi","330006",{"type":54,"coordinates":146},[147,148],115.85306,28.68396,{"lat":148,"lon":147},{"facility":151,"status":47,"city":142,"state":143,"zip":152,"country":93,"countryCode":94,"cosmosGeoPoint":153,"geoPoint":155,"contacts":29},"The First Affiliated Hospital of Nanchang University Branch Xianghu","332000",{"type":54,"coordinates":154},[147,148],{"lat":148,"lon":147},{"facility":157,"status":47,"city":158,"state":159,"zip":160,"country":93,"countryCode":94,"cosmosGeoPoint":161,"geoPoint":165,"contacts":29},"Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch","Tianjin","Tianjin Municipality","301617",{"type":54,"coordinates":162},[163,164],117.17667,39.14222,{"lat":164,"lon":163},{"facility":167,"status":47,"city":168,"state":29,"zip":169,"country":170,"countryCode":171,"cosmosGeoPoint":172,"geoPoint":176,"contacts":29},"Auckland City Hospital","Auckland","1023","New Zealand","NZ",{"type":54,"coordinates":173},[174,175],174.76349,-36.84853,{"lat":175,"lon":174},{"type":178,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100640438","an-investigational-study-of-bg-75202-alone-and-in-combination-with-other-agents-in-patients-with-myeloid-malignancies-100640438",false,"NCT07619287","An Investigational Study of BG-75202 Alone and in Combination With Other Agents in Patients With Myeloid Malignancies","A Phase 1a\u002F1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of BG-75202, Alone and in Combination With Other Agents, in Patients With Myeloid Malignancies","Inclusion Criteria:\n\n* Patients must be ≥ 18 years of age (or the legal age of consent in the jurisdiction in which the study is taking place), inclusive, at the time of signing the Informed consent form (ICF).\n* Patients must have a confirmed diagnosis of myeloid malignancies based on 2016 World Health Organization criteria, and meet the following categories:\n\n  * Relapsed\u002Frefractory; myeloid malignancies after ≥1 prior systemic therapy, per ELN; 2022 criteria; patients with actionable genetic alteration must have previously received targeted therapies unless contraindicated, unavailable\u002Finaccessible, or declined by patient.\n* Patients must have a stable Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2.\n\nExclusion Criteria:\n\n* Prior exposure to KAT6A\u002FB inhibitors\u002Fdegraders.\n* A diagnosis of acute promyelocytic leukemia or BCR-ABL-positive leukemia.\n* Known central nervous system involvement by leukemia\n* Use of antileukemic therapies without sufficient washout period\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":189,"type":190},118,"ESTIMATED","INTERVENTIONAL",[193],"PHASE1","The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of BG-75202 (KAT6A\u002FB inhibitor) alone and in combination with other agents in patients with myeloid malignancies.",[196],"Myeloid Malignancy",[198],"KAT6 inhibitor","2026-08-17",{"date":201,"type":202},"2026-08-18","ACTUAL",{"date":204,"type":202},"2026-06-23",{"date":206,"type":190},"2028-09-30",{"name":5,"class":6},13]