[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650930":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":30,"locations":30,"responsibleParty":39,"collaborators":30,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":30,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":30,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":69,"whyStopped":30,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":30},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Aquatic therapy group","EXPERIMENTAL","Supervised 12- week water-based exercise program. Each aquatic session consists of four standardized phases. The first five minutes include supported standing, diaphragmatic breathing, and lateral-costal expansion. The subsequent eight-minute warm-up includes forward, backward, and lateral water walking; ankle dorsiflexion and plantarflexion; heel raises; gentle knee flexion; marching; and controlled hip movement.\n\nThe 25-minute main phase comprises brisk water walking, marching, hip abduction and extension, hamstring curls, supported mini-squats, step-touch movements, calf raises, controlled leg circles, and upper-limb sweeping movements coordinated with breathing.\n\nThe final seven-minute cool-down includes progressively slower water walking, ankle pumps, and gentle stretching of the gastrocnemius-soleus complex, hamstrings, quadriceps, and hip flexors.",[13],"Other: aquatic therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"land-based exercise group","ACTIVE_COMPARATOR","The land-based 12- week program combined low-impact aerobic training, lower-limb strengthening, muscle-pump exercises, flexibility training, postural control, and breathing exercises. Each session will begin with an eight-minute warm-up consisting of diaphragmatic breathing, ankle dorsiflexion and plantarflexion, heel and toe raises, slow marching, gentle trunk rotation, and low-intensity walking.\n\nThe aerobic phase will last approximately 12 minutes and consist of walking on level ground or on a treadmill. The 18-minute strengthening phase will include sit-to-stand exercises, supported mini-squats, heel raises, standing hip abduction and extension, knee flexion and extension, low step-ups, supine bridging, and side-lying hip abduction.",[19],"Other: land- based exercise",{"label":21,"type":6,"description":22,"interventionNames":23},"control group","Participants will receive manual lymphatic drainage, intermittent pneumatic compression, a weight-reduction diet, and a compression garment will be provided by the research team.",[24],"Other: usual care",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"aquatic therapy","Hydotherapy for lipedema. Sessions will be conducted in a therapeutic pool maintained at approximately 28-30°C. Immersion depth will be individualized between the xiphoid process and shoulder level according to participant height, balance, symptom severity, and exercise tolerance.",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"land- based exercise","Sessions will be supervised by a physiotherapist and conducted in an area equipped with supportive chairs, stable handrails, low steps, exercise mats, and light resistance bands. Participants wear comfortable clothing and supportive footwear.",[15],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"usual care","Participants will receive a standardized education session at baseline addressing lipedema, skin care, symptom monitoring, avoidance of prolonged immobility, maintenance of habitual daily activity, and clinical warning signs requiring medical review",[21],{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Ebtesam Nabil","Assistant professor at Physical Therapy Department for Cardiovascular\u002FRespiratory Disorder and Geriartics","100650930","aquatic-versus-land-based-exercise-in-women-with-lipedema-100650930",false,"NCT07756463","Aquatic Versus Land-Based Exercise in Women With Lipedema","Effects of Aquatic and Land-Based Exercise on Functional, Clinical, and Lymphatic Outcomes in Women With Lipedema: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Women diagnosed with lipedema for at least five years\n* Had stage 2 or 3 and type 2 or 3 disease\n* Had a body mass index of ≥25 and \\\u003C40 kg\u002Fm²\n* Able to walk independently, with or without their usual assistive device\n* Had received medical clearance to participate in moderate-intensity aquatic and land-based exercise\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Had clinically significant lymphedema, uncontrolled chronic venous insufficiency, acute thrombosis, or another major cause of lower-limb edema\n* Had open wounds, active skin infection, fever, or another infectious condition incompatible with pool use\n* Had uncontrolled cardiovascular, metabolic, respiratory, or neurological disorder that could compromise exercise safety; a cardiac pacemaker or congestive heart failure; pregnancy; active cancer or ongoing chemotherapy, immunotherapy, or radiotherapy\n* Had history of bariatric surgery, recent major surgery, or liposuction; current use of weight-loss medication\n* Had current participation in structured aquatic or lower-limb exercise exceeding the protocol-defined threshold; or severe fear of water or inability to enter and exit the pool safely.","FEMALE","35 Years","45 Years",{"count":54,"type":55},60,"ESTIMATED","INTERVENTIONAL",[58],"NA","To evaluate optimal workout environments, a 12-week study assigned women with moderate-to-severe lipedema to three distinct protocols: supervised pool workouts, equivalent land-based training, or basic standard monitoring. Researchers tracked walking endurance alongside tissue composition, fluid levels, pain intensity, and general well-being. The trial posited that structured activity beats routine care alone, with water-based exercise potentially offering superior relief due to buoyancy and hydrostatic fluid compression.",[61],"Lipedema",[63,64,65,66,67,68],"lipedema","hydrotherapy","therapeutic exercise","six-minute walk test","symptom burden","quality of life","NOT_YET_RECRUITING","2026-08-08",{"date":72,"type":73},"2026-08-11","ACTUAL",{"date":75,"type":55},"2026-08-27",{"date":77,"type":55},"2027-10",{"name":5,"class":6}]