[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508736":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":24,"studyPopulation":25,"armGroups":26,"interventions":31,"overallOfficials":36,"centralContacts":41,"locations":48,"responsibleParty":128,"collaborators":20,"id":130,"slug":131,"hasResults":132,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":132,"sex":138,"minAge":20,"maxAge":20,"enrollmentInfo":139,"targetDuration":20,"studyType":142,"phases":20,"briefSummary":143,"conditions":144,"keywords":154,"overallStatus":51,"whyStopped":20,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":173},{"fullName":5,"class":6},"Santé Arménie French-Armenian Research Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"Systemic manifestations and evolution of the diseases under treatment by disease-specific activity scores","Description of Initial manifestations and the progress of these diseases.\n\nThe progress of these diseases is assessed in the form of disease-specific activity scores:\n\n* ANCA-positive vasculitis - BVAS\n* Takayasu arthritis - NIH criteria\n* Rheumatoid arthritis - DAS28\n* Sjogren syndrome - ESSDAI, ESSRPI","Through study completion, an average of 5 years",[14,17],{"measure":15,"description":16,"timeFrame":12},"Identification of rare clinical forms","Clinical and biological correlations to characterize rare clinical forms of each pathology",{"measure":18,"description":19,"timeFrame":12},"Prognostic factors of the diseases","Interest in prognostic factors obtained through more targeted radiological examinations and correlation with the response to different treatments.",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","PROSPECTIVE","Autoimmune and auto inflammatory diseases are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation.\n\nThey represent a group of diseases characterized by excessive autoimmune or inflammatory reaction leading to various organ damage and drop in patient's quality of life, usually underlined by particular genetic factors and environmental triggers.\n\nThe progress of these diseases is often evaluated in the form of activity scores.\n\nA number of scores are available to predict the evolution of autoimmune autoinflammatory diseases.\n\nFor a long time, these pathologies have remained slightly explored because of their complex physiopathology and the absence of specific therapies.\n\nIn the last few years, significant progress has been made in terms of both pathophysiology and treatment.\n\nTreatment with biological targeted therapies transformed the prognosis and survival of the patients, improved their quality of life and underlined the necessity of a global management of these patients.\n\nIn Armenia, the epidemiological elements of these pathologies are not known, nor are the circumstances of their discovery. The initial biological manifestations and the management of these patients are variable from one center to another, whether in terms of supportive or specific therapeutic elements.","Outpatients and inpatients at participating centers, major and minor patients with a confirmed diagnosis of at least one of autoimmune systemic diseases",[27],{"label":28,"type":20,"description":20,"interventionNames":29},"Systemic autoimmune and autoinflammatory diseases",[30],"Other: Usual medical management of patients, additional blood and stool samples for biobanking",[32],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":20},"Usual medical management of patients, additional blood and stool samples for biobanking","For all systemic diseases the following data will be collected:\n\nClinical examination, Laboratory data, Current medications, Constitution of biobanking.\n\nFor each disease:\n\nPathology specific Activity score, Global subjective disease activity by patient and by physician.",[28],[37],{"name":38,"affiliation":39,"role":40},"Merry Mazmanian, Dr.","Santé Arménie French - Armenian Academic Research Organization FAARO","STUDY_DIRECTOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Arsene Mekinian, Prof.","CONTACT","01 49 28 23 92","+33","arsene.mekinian@aphp.fr",[49,68,80,94,104,116],{"facility":50,"status":51,"city":52,"state":20,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Hematology Center after Prof.R.H. Yeolyan","RECRUITING","Yerevan","0014","Armenia","AM",{"type":57,"coordinates":58},"Point",[59,60],44.5126,40.17765,{"lat":60,"lon":59},[63,66],{"name":64,"role":44,"phone":20,"phoneExt":20,"email":65},"Liana Hambardzumyan, Dr.","lianahambardzumyan00@gmail.com",{"name":64,"role":67,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"facility":69,"status":51,"city":52,"state":20,"zip":70,"country":54,"countryCode":55,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"Nairi Medical Center, Rheumatology Department","0015",{"type":57,"coordinates":72},[59,60],{"lat":60,"lon":59},[75,78],{"name":76,"role":44,"phone":20,"phoneExt":20,"email":77},"Vahan Mukuchayn, Dr.","vmukuchyan@gmail.com",{"name":79,"role":67,"phone":20,"phoneExt":20,"email":20},"Vahan Mukuchyan, Dr.",{"facility":81,"status":82,"city":52,"state":20,"zip":83,"country":54,"countryCode":55,"cosmosGeoPoint":84,"geoPoint":86,"contacts":87},"Heratsi Hospital Complex n°1, Rheumatology Department","NOT_YET_RECRUITING","0025",{"type":57,"coordinates":85},[59,60],{"lat":60,"lon":59},[88,91,93],{"name":89,"role":44,"phone":20,"phoneExt":20,"email":90},"Knarik Ginosyan, Dr.","kginosyan@gmail.com",{"name":38,"role":44,"phone":20,"phoneExt":20,"email":92},"merry.mazmanian@santearmenie.org",{"name":89,"role":67,"phone":20,"phoneExt":20,"email":20},{"facility":95,"status":51,"city":52,"state":20,"zip":83,"country":54,"countryCode":55,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Heratsi Hospital Complex №1, Allergology Department",{"type":57,"coordinates":97},[59,60],{"lat":60,"lon":59},[100,103],{"name":101,"role":44,"phone":20,"phoneExt":20,"email":102},"Armine Hakobyan, Dr.","arminehakobyan.v@gmail.com",{"name":101,"role":67,"phone":20,"phoneExt":20,"email":20},{"facility":105,"status":51,"city":52,"state":20,"zip":106,"country":54,"countryCode":55,"cosmosGeoPoint":107,"geoPoint":109,"contacts":110},"Mikaelyan Institute of Surgery, Rheumatology Department","0052",{"type":57,"coordinates":108},[59,60],{"lat":60,"lon":59},[111,115],{"name":112,"role":44,"phone":113,"phoneExt":20,"email":114},"Valentina Vardanyan, Dr.","+37499066115","valentina.vardanyan@gmail.com",{"name":112,"role":67,"phone":20,"phoneExt":20,"email":20},{"facility":117,"status":82,"city":52,"state":20,"zip":118,"country":54,"countryCode":55,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},"Erebouni Medical Center, Rheumatology Department","0087",{"type":57,"coordinates":120},[59,60],{"lat":60,"lon":59},[123,125],{"name":124,"role":67,"phone":20,"phoneExt":20,"email":20},"Armine Haroyan, Dr.",{"name":126,"role":127,"phone":20,"phoneExt":20,"email":20},"Magda Osipyan, Dr.","SUB_INVESTIGATOR",{"type":129,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100508736","armenian-nationwide-registry-of-systemic-autoimmune-and-autoinflammatory-diseases-100508736",false,"NCT05904301","Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases","Armenian Nationwide Registry of Systemic Autoimmune and Autoinflammatory Diseases","NAREG","Inclusion Criteria:\n\n1. Patients with a confirmed diagnosis of at least one of following autoimmune systemic diseases:\n\n   Behcet disease, ANCA -positive vasculitis, Takayasu arteritis, Giant cell arteritis, Systemic sclerosis, Sjogren syndrome, Rheumatoid arthritis, Spondylarthritis (psoriatic, ankylosing, crohn's related), Angioedema hereditary and acquired, Pediatric dermatology, Autoinflammatory diseases (hereditary and acquired), Unexplained infertility, Immune thrombocytopenic purpura\u002F Autoimmune hemolytic anemia (ITP, AHA), Primary anti-phospholipid syndrome (APS), Celiac disease.\n2. Age: major and minor\n3. Patients who have been informed and provided with written informed consent to participate Or consent from legal representative\n\nExclusion Criteria:\n\n1. Patients refusing to participate in the registry\n2. Non-consent from legal representative\n3. Breastfeeding or pregnant patients","ALL",{"count":140,"type":141},800,"ESTIMATED","OBSERVATIONAL","Longitudinal prospective multicenter Armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.",[145,146,147,148,149,150,151,152,153],"Behcet Disease","Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis","Takayasu Arteritis","Giant Cell Arteritis","Sjogren's Syndrome","Rheumatoid Arthritis","Hereditary and Acquired Angioedema","Primary Antiphospholipid Syndrome","Celiac Disease",[155,156,157,158,159,160,161,162,163],"arthritis","autoimmune","systemic","autoinflammatory","Behcet","Takayasu","Giant Cell","Angioedema","APS","2025-04-04",{"date":166,"type":167},"2025-04-08","ACTUAL",{"date":169,"type":167},"2023-06-21",{"date":171,"type":141},"2028-06-30",{"name":5,"class":6},6]