[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636400":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":25,"responsibleParty":39,"collaborators":25,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":25,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":25,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":64,"whyStopped":25,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":25},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"cTBS","EXPERIMENTAL","cTBS: Each session will consist of a single continuous 600-pulse train delivered over 40 seconds, comprising 50 Hz bursts repeated at 5 Hz.",[13,14],"Device: Active TMS","Device: Sham TMS",{"label":16,"type":10,"description":17,"interventionNames":18},"iTBS","iTBS: Each session (\\~3.5 min) will consist of 20 trains of 10 seconds, comprising 2 seconds of 50 Hz bursts repeated at 5 Hz, with 8-second inter-train intervals, totaling 600 pulses per session.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active TMS","Theta Burst Stimulation (TBS): TBS will be delivered using a MagVenture MagPro X100 stimulator with a Cool-B65 A\u002FP coil. One session of 600 pulses will be delivered per visit.",[9,16],null,{"type":21,"name":27,"description":23,"armGroupLabels":28,"otherNames":25},"Sham TMS",[9,16],[30],{"name":31,"affiliation":5,"role":32},"Nicholas L Balderston","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Nicholas Balderston","CONTACT","12157463058","nicholas.balderston@pennmedicine.upenn.edu",{"type":40,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100636400","arousal-related-memory-following-theta-burst-stimulation-100636400",false,"NCT07565194","Arousal-related Memory Following Theta Burst Stimulation.","Arousal-related Memory of Movie Clips During Individualized IPS Targeting fMRI and TBS.","Inclusion Criteria:\n\n* Able to provide informed consent\n* Right-handed (to ensure consistency in motor threshold determination)\n\nExclusion Criteria:\n\n* Non-English speaking\n* Significant medical problems\n* Current or past psychiatric disorder\n* Active or history of suicidal ideation\n* Alcohol or drug problems in the past year, or lifetime alcohol or drug dependence\n* Medications affecting the central nervous system\n* History of seizure, epilepsy, or other neurological problems\n* Any increased risk for seizure\n* Pregnancy\n* Medical conditions that increase risk for fMRI or TMS\n* Metal in the body that makes MRI unsafe\n* Medical implants\n* Claustrophobia\n* Orthostatic hypotension",true,"ALL","18 Years","50 Years",{"count":53,"type":54},120,"ESTIMATED","INTERVENTIONAL",[57],"NA","Aim 1: Active cTBS to IPS will disrupt arousal-dependent temporal memory, reflected in reduced relative order discrimination accuracy and expanded temporal distance estimates, relative to sham.\n\nAim 2: Active iTBS to IPS will enhance arousal-dependent temporal memory, reflected in improved relative order discrimination accuracy and compressed temporal distance estimates, relative to sham.\n\nAim 3: Baseline physiological arousal, trait anxiety (STAI), Beck Anxiety Inventory (BAI), trauma symptoms (PCL-5), and individualized E-field strength will predict the magnitude of TBS-induced behavioral changes in temporal memory.",[60],"Anxiety",[62,63],"anxiety","transcranial magnetic stimulation","NOT_YET_RECRUITING","2026-08-04",{"date":67,"type":68},"2026-08-05","ACTUAL",{"date":70,"type":54},"2026-10-01",{"date":72,"type":54},"2030-05-30",{"name":5,"class":6}]