[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100647849":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":21,"centralContacts":26,"locations":10,"responsibleParty":36,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"Coventry University","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Heart Failure with reserved ejection fraction",null,[12],"Other: Study Assessment",{"label":14,"type":10,"description":10,"interventionNames":15},"Heart failure with preserved ejection fraction",[12],[17],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Study Assessment","* Collection of demographic details (age, sex, ethnicity, alcohol consumption, and smoking status)\n* Collection of previous\u002Fexisting results from the participants medical records will include the following:\n* Medical History: Documented diagnoses, comorbidities, and history of cardiovascular conditions.\n* Concomitant Medications: Details of all current prescribed and over-the-counter medications relevant to their clinical care.\n* Physical Examination and Vital Signs: Blood pressure, pulse rate, and any other routinely recorded cardiovascular parameters available within their clinical record.\n\nAll data will be collected only from information already recorded as part of routine clinical care.\n\nIn addition to these, the participant will undergo the study assessments: Arterial stiffness, endothelial function, Cardiac output response to stress test and Voice recognition.",[9,14],[22],{"name":23,"affiliation":24,"role":25},"Prithwish Banerjee","University Hospitals Coventry & Warwickshire NHS Trust","PRINCIPAL_INVESTIGATOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Prithwish Banerjee, MBBS, Dip Card, MD, MRCP, FES","CONTACT","07803711713","Prithwish.Banerjee@uhcw.nhs.uk",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"Djordje Jakovljevic","07522694321","djordje.jakovljevic@coventry.ac.uk",{"type":37,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100647849","arterial-stiffness-and-endothelial-function-in-heart-failure-100647849",false,"NCT07713719","Arterial Stiffness and Endothelial Function in Heart Failure","Pathophysiology of Heart Failure: the Role of Arterial Stiffness and Endothelial Function","ASEF-HF","Inclusion Criteria:\n\n* Male and female ≥ 18 years old.\n\n  * Have a confirmed de-novo diagnosis of Heart failure with preserved ejection fraction or Heart failure with reserved ejection fraction. Common HF phenotypes (e.g., hypertension, diabetes, obesity) will be recorded as part of routine baseline data but will not influence recruitment or sampling. .\n  * Have stable Heart failure in the opinion of the investigator.\n  * Have ability, in the opinion of the investigator, to participate in study activities.\n  * Able to provide written informed consent.\n\nExclusion Criteria:\n\n* • Inability to provide verbal informed consent.\n\n  * Presenting with severe symptoms; major co-morbidity or other alternative diagnoses (e.g., malignancy, severe respiratory disease, severe mental health problem\u002Fs).\n  * Recent acute coronary syndrome (within 60 days).\n  * Severe physical disability preventing independence.\n  * Severe renal insufficiency.\n  * Pregnancy (Present or planned).\n  * Life expectancy less than 12 months","ALL","18 Years","90 Years",{"count":50,"type":51},50,"ESTIMATED","OBSERVATIONAL","Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes. This study aims to improve understanding of the role of blood vessels in people with heart failure.\n\nThe study will assess how arterial stiffness (how stiff blood vessels are) and endothelial function (how well the lining of blood vessels functions) change over time and respond to treatments received as part of routine clinical care. Blood vessel function and heart performance will be assessed at three time points:\n\n* At baseline (when Patients are first diagnosed with heart failure).\n* After completing 4 ± 2 weeks of heart-failure medicines prescribed to patients as part of their routine clinical care.\n* After completion of cardiac rehabilitation program as a part of their routine clinical care.\n\nAll assessments are non-invasive.",[55],"Heart Failure",[57,58,59],"Arterial stiffness","Endothelial Function","Heart failure","NOT_YET_RECRUITING","2026-07-14",{"date":63,"type":64},"2026-07-20","ACTUAL",{"date":66,"type":51},"2026-08",{"date":68,"type":51},"2028-06",{"name":5,"class":6}]