[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100653262":3},{"organization":4,"outcomesModule":7,"designInfo":33,"detailedDescription":41,"studyPopulation":11,"armGroups":42,"interventions":53,"overallOfficials":11,"centralContacts":58,"locations":68,"responsibleParty":86,"collaborators":11,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":11,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":11,"enrollmentInfo":99,"targetDuration":11,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":71,"whyStopped":11,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Capital Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"The proportion of patients receiving intravenous thrombolysis.",null,"24 hours within last known well",[14,17,19,23],{"measure":15,"description":11,"timeFrame":16},"Proportion of patients with an modified Rankin Scale score (the total score ranges from 0 to 6; a higher score indicates a more severe disability) of 0-1 at 90 days","90 days after stroke onset",{"measure":18,"description":11,"timeFrame":16},"90-Day modified Rankin Scale score (the total score ranges from 0 to 6; a higher score indicates a more severe disability)",{"measure":20,"description":21,"timeFrame":22},"Early neurological improvement","Defined as an improvement of at least 4 points on the National Institutes of Health Stroke Scale (NIHSS, 0-42 score, a higher score indicates a more severe condition) score within 24 hours, or a score of 0.","24 hours after admission",{"measure":24,"description":11,"timeFrame":12},"Time from admission to intravenous thrombolysis (DNT) in patients receiving intravenous thrombolysis",[26,29,31],{"measure":27,"description":11,"timeFrame":28},"Proportion of symptomatic intracranial hemorrhage within 36 hours of thrombolysis","within 36 hours of thrombolysis",{"measure":30,"description":11,"timeFrame":28},"Proportion of any type of intracranial hemorrhage within 36 hours of thrombolysis",{"measure":32,"description":11,"timeFrame":16},"90-day all-cause mortality rate.",{"allocation":34,"interventionModel":35,"interventionModelDescription":11,"primaryPurpose":36,"observationalModel":11,"timePerspective":11,"maskingInfo":37},"RANDOMIZED","PARALLEL","HEALTH_SERVICES_RESEARCH",{"masking":38,"maskingDescription":11,"whoMasked":39},"SINGLE",[40],"OUTCOMES_ASSESSOR","This single-center, randomized controlled, open-label, blinded-endpoint trial aims to evaluate whether an AI-assisted decision support tool increases the proportion of acute ischemic stroke patients (onset \\\u003C24 h) receiving intravenous thrombolysis at a primary hospital in China, and to assess its impact on clinical outcomes. Using cluster randomization at the level of attending physicians , the intervention group adds the AI tool to routine assessment, while the control group follows current guidelines and standard institutional protocols; both groups are not permitted to delay routine care for research purposes.",[43,49],{"label":44,"type":45,"description":46,"interventionNames":47},"AI-Assisted Group","EXPERIMENTAL","Patients receive care from attending physicians who use the AI-assisted thrombolysis decision support tool in addition to routine assessment, with the final treatment decision left to the physician's clinical judgment.",[48],"Other: AI-assisted thrombolysis decision support",{"label":50,"type":51,"description":52,"interventionNames":11},"Standard Treatment Group","NO_INTERVENTION","Patients receive standard acute ischemic stroke care according to the hospital's current protocols without the use of the AI tool.",[54],{"type":6,"name":55,"description":56,"armGroupLabels":57,"otherNames":11},"AI-assisted thrombolysis decision support","The AI-assisted thrombolysis decision support tool is used by attending physicians in addition to routine stroke evaluation. After the physician enters key patient data, the system generates real-time prompts on whether the patient meets criteria for intravenous thrombolysis, recommended additional tests and risk alerts for thrombolysis. The final treatment decision remains with the treating clinician.",[44],[59,64],{"name":60,"role":61,"phone":62,"phoneExt":11,"email":63},"Xunming Ji","CONTACT","01083198962","jixm@ccmu.edu.cn",{"name":65,"role":61,"phone":66,"phoneExt":11,"email":67},"Chuanjie Wu","01083199439","wuchuanjie@ccmu.edu.cn",[69],{"facility":70,"status":71,"city":72,"state":73,"zip":11,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"Liuyang Jili Hospital","RECRUITING","Changsha","Hunan","China","CN",{"type":77,"coordinates":78},"Point",[79,80],112.97087,28.19874,{"lat":80,"lon":79},[83],{"name":84,"role":61,"phone":85,"phoneExt":11,"email":11},"Yong He","073183615622",{"type":87,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ji Xunming,MD,PhD","Professor of Neurology, Xuanwu Hospital, Capital Medical University","100653262","artificial-intelligence-support-for-stroke-100653262",false,"NCT07785492","Artificial Intelligence Support for Stroke","Artificial Intelligence-Assisted Decision Support for Intravenous Thrombolysis in Acute Ischemic Stroke at Basic Hospitals in China (ASSIST)","Inclusion Criteria:\n\n1. Age ≥18 years.\n2. Clinical diagnosis of acute ischemic stroke.\n3. Onset time (last known well) \\\u003C24 hours.\n4. CT or MRI examination excluding intracerebral hemorrhage.\n5. Signed informed consent by the patient or a legally authorized representative\n\nExclusion Criteria:\n\n1. Currently participating in another interventional clinical trial related to drugs or devices.\n2. Pregnant women.\n3. Has received intravenous thrombolysis at another hospital.\n4. Has completed a definitive reperfusion therapy decision at another hospital and is transferred to this hospital solely for follow-up observation or rehabilitation.","ALL","18 Years",{"count":100,"type":101},516,"ESTIMATED","INTERVENTIONAL",[104],"NA","This study investigates whether an AI-assisted decision support tool, compared with standard care, increases the proportion of acute ischemic stroke patients receiving intravenous thrombolysis within 24 hours of symptom onset at a primary hospital in China, while also evaluating its impact on clinical outcomes, treatment timelines, and safety.",[107],"Ischemic Stroke, Acute",[109,110,111,112],"Randomized Controlled Trial","Stroke","AI","Thrombolysis","2026-08-26",{"date":115,"type":116},"2026-08-27","ACTUAL",{"date":113,"type":116},{"date":119,"type":101},"2027-03-31",{"name":5,"class":6},1]