[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632696":3},{"organization":4,"outcomesModule":7,"designInfo":44,"detailedDescription":11,"studyPopulation":11,"armGroups":55,"interventions":75,"overallOfficials":11,"centralContacts":85,"locations":91,"responsibleParty":287,"collaborators":11,"id":289,"slug":290,"hasResults":291,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":11,"eligibilityCriteria":295,"healthyVolunteers":291,"sex":296,"minAge":297,"maxAge":11,"enrollmentInfo":298,"targetDuration":11,"studyType":301,"phases":302,"briefSummary":304,"conditions":305,"keywords":308,"overallStatus":94,"whyStopped":11,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":323},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Percentage change of body weight",null,"From randomization to Week 52",[14,16,18,20,23,26,28,30,32,35,38,40,42],{"measure":15,"description":11,"timeFrame":12},"Change in body mass index (BMI)",{"measure":17,"description":11,"timeFrame":12},"Change in waist circumference",{"measure":19,"description":11,"timeFrame":12},"Change in total body fat",{"measure":21,"description":22,"timeFrame":12},"Change in abdominal visceral fat area","Abdominal visceral fat area is quantified by CT scan",{"measure":24,"description":25,"timeFrame":12},"Change in hepatic fat content","Hepatic fat content is quantified by controlled attenuation parameter (CAP), measured by Fibroscan.",{"measure":27,"description":11,"timeFrame":12},"Change in blood pressure",{"measure":29,"description":11,"timeFrame":12},"Change in serum lipid profile",{"measure":31,"description":11,"timeFrame":12},"Changes in blood glucose",{"measure":33,"description":34,"timeFrame":12},"Changes in insulin sensitivity","Insulin sensitivity is assessed by HOMA-IR index",{"measure":36,"description":37,"timeFrame":12},"Changes in pancreatic β-cell function","Pancreatic β-cell function is assessed by HOMA-β index",{"measure":39,"description":11,"timeFrame":12},"Change in pulse wave velocity (PWV)",{"measure":41,"description":11,"timeFrame":12},"Quality of sleep measured by the Pittsburgh sleep quality index (PSQI)",{"measure":43,"description":11,"timeFrame":12},"Quality of life measured by the 12-item Short-Form Health Survey Questionnaire (SF-12)",{"allocation":45,"interventionModel":46,"interventionModelDescription":11,"primaryPurpose":47,"observationalModel":11,"timePerspective":11,"maskingInfo":48},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":49,"maskingDescription":11,"whoMasked":50},"QUADRUPLE",[51,52,53,54],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR",[56,62,67,71],{"label":57,"type":58,"description":59,"interventionNames":60},"Placebo plus Intensive Lifestyle Intervention","EXPERIMENTAL","After 16-week intensive treatment with mazdutide, participants are randomized into four different arms. In this arm, participants receive placebo once weekly plus intensive lifestyle intervention for 52 weeks during the weight maintenance period.",[61],"Behavioral: Intensive Lifestyle Intervention",{"label":63,"type":58,"description":64,"interventionNames":65},"Mazdutide","After 16-week intensive treatment with mazdutide, participants are randomized into four different arms. In this arm, participants receive mazdutide 3.0 mg once weekly for 52 weeks during the weight maintenance period.",[66],"Drug: Mazdutide",{"label":68,"type":58,"description":69,"interventionNames":70},"Mazdutide Plus Intensive Lifestyle Intervention","After 16-week intensive treatment with mazdutide, participants are randomized into four different arms. In this arm, participants receive mazdutide 3.0 mg once weekly plus intensive lifestyle intervention for 52 weeks during the weight maintenance period.",[66,61],{"label":72,"type":73,"description":74,"interventionNames":11},"Standard Health Education (Control)","NO_INTERVENTION","After 16-week intensive treatment with mazdutide, participants are randomized into four different arms. In this arm, participants receive standard health education only for 52 weeks during the weight maintenance period.",[76,80],{"type":77,"name":63,"description":78,"armGroupLabels":79,"otherNames":11},"DRUG","Mazdutide is administered subcutaneously at 3.0 mg once weekly for 52 weeks during the weight maintenance period.",[63,68],{"type":81,"name":82,"description":83,"armGroupLabels":84,"otherNames":11},"BEHAVIORAL","Intensive Lifestyle Intervention","A structured intensive lifestyle intervention including individualized dietary counseling, physical activity guidance, and behavioral modification support for 52 weeks during the weight maintenance period.",[68,57],[86],{"name":87,"role":88,"phone":89,"phoneExt":11,"email":90},"JINGJING JIANG, MD, PhD","CONTACT","86-21-64041990","jiang.jingjing@zs-hospital.sh.cn",[92,113,129,145,161,177,192,208,219,230,240,256,272],{"facility":93,"status":94,"city":95,"state":96,"zip":97,"country":98,"countryCode":99,"cosmosGeoPoint":100,"geoPoint":105,"contacts":106},"The Second Affiliated Hospital of Chongqing Medical University","RECRUITING","Chongqing","Chongqing Municipality","400000","China","CN",{"type":101,"coordinates":102},"Point",[103,104],106.55771,29.56026,{"lat":104,"lon":103},[107,111],{"name":108,"role":88,"phone":109,"phoneExt":11,"email":110},"Dongfang Liu, MD","86-023-63693000","ldf023023@qq.com",{"name":108,"role":112,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"facility":114,"status":94,"city":115,"state":116,"zip":117,"country":98,"countryCode":99,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Fujian Provincial Hospital, Affiliated to Fuzhou University","Fuzhou","Fujian","350000",{"type":101,"coordinates":119},[120,121],119.30611,26.06139,{"lat":121,"lon":120},[124,128],{"name":125,"role":88,"phone":126,"phoneExt":11,"email":127},"Gang Chen, MD","86-0591-88216000","chengangfj@163.com",{"name":125,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":130,"status":94,"city":131,"state":116,"zip":132,"country":98,"countryCode":99,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"The First Affiliated Hospital of Xiamen University","Xiamen","361003",{"type":101,"coordinates":134},[135,136],118.08187,24.47979,{"lat":136,"lon":135},[139,143],{"name":140,"role":88,"phone":141,"phoneExt":11,"email":142},"Xin Zheng, MD","86-0592-2132222","zx2001528@163.com",{"name":144,"role":112,"phone":11,"phoneExt":11,"email":11},"Changqin Liu, MD",{"facility":146,"status":94,"city":147,"state":148,"zip":149,"country":98,"countryCode":99,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Zhongnan Hospital of Wuhan University","Wuhan","Hubei","430000",{"type":101,"coordinates":151},[152,153],114.26667,30.58333,{"lat":153,"lon":152},[156,160],{"name":157,"role":88,"phone":158,"phoneExt":11,"email":159},"Zhe Dai, MD","86-027-67812999","daizhewhu@outlook.com",{"name":157,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":162,"status":94,"city":163,"state":164,"zip":165,"country":98,"countryCode":99,"cosmosGeoPoint":166,"geoPoint":170,"contacts":171},"Nanjing First Hospital, Nanjing Medical University","Nanjing","Jiangsu","210000",{"type":101,"coordinates":167},[168,169],118.77778,32.06167,{"lat":169,"lon":168},[172,176],{"name":173,"role":88,"phone":174,"phoneExt":11,"email":175},"Qian Li, MD","86-025-52271000","qbb12345yd@163.com",{"name":173,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":178,"status":94,"city":179,"state":164,"zip":180,"country":98,"countryCode":99,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University","Suzhou","215000",{"type":101,"coordinates":182},[183,184],120.59538,31.30408,{"lat":184,"lon":183},[187,191],{"name":188,"role":88,"phone":189,"phoneExt":11,"email":190},"Zhimin Ma, MD","86-0512-69584800","mazhimin01@sina.com",{"name":188,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":193,"status":94,"city":194,"state":195,"zip":196,"country":98,"countryCode":99,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Huadong Hospital, Fudan University","Shanghai","Shanghai Municipality","200000",{"type":101,"coordinates":198},[199,200],121.45806,31.22222,{"lat":200,"lon":199},[203,207],{"name":204,"role":88,"phone":205,"phoneExt":11,"email":206},"Bin Lu, PhD","86-021-62483180","lubinfd@126.com",{"name":204,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":209,"status":94,"city":194,"state":195,"zip":196,"country":98,"countryCode":99,"cosmosGeoPoint":210,"geoPoint":212,"contacts":213},"Renji Hospital, Shanghai Jiao Tong University School of Medicine",{"type":101,"coordinates":211},[199,200],{"lat":200,"lon":199},[214,218],{"name":215,"role":88,"phone":216,"phoneExt":11,"email":217},"Jing Ma, PhD","86-021-58752345","cherry1996@live.cn",{"name":215,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":220,"status":94,"city":194,"state":195,"zip":196,"country":98,"countryCode":99,"cosmosGeoPoint":221,"geoPoint":223,"contacts":224},"Shanghai Tenth People's Hospital, School of Medicine, Tongji University",{"type":101,"coordinates":222},[199,200],{"lat":200,"lon":199},[225,229],{"name":226,"role":88,"phone":227,"phoneExt":11,"email":228},"Shen Qu, PhD","86-021-66303680","qushencn@hotmail.com",{"name":226,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":231,"status":94,"city":194,"state":195,"zip":232,"country":98,"countryCode":99,"cosmosGeoPoint":233,"geoPoint":235,"contacts":236},"Zhongshan Hospital, Fudan University","200030",{"type":101,"coordinates":234},[199,200],{"lat":200,"lon":199},[237,238],{"name":87,"role":88,"phone":89,"phoneExt":11,"email":90},{"name":239,"role":112,"phone":11,"phoneExt":11,"email":11},"HUIJIE ZHANG, MD, PhD",{"facility":241,"status":94,"city":242,"state":243,"zip":244,"country":98,"countryCode":99,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"The Affiliated Hospital of Southwest Medical University","Luzhou","Sichuan","646000",{"type":101,"coordinates":246},[247,248],105.42575,28.8903,{"lat":248,"lon":247},[251,255],{"name":252,"role":88,"phone":253,"phoneExt":11,"email":254},"Yong Xu, MD","86-0830-3165233","xywyll@aliyun.com",{"name":252,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":257,"status":94,"city":258,"state":259,"zip":260,"country":98,"countryCode":99,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"Zhejiang Provincial People's Hospital","Hangzhou","Zhejiang","310000",{"type":101,"coordinates":262},[263,264],120.16142,30.29365,{"lat":264,"lon":263},[267,271],{"name":268,"role":88,"phone":269,"phoneExt":11,"email":270},"Xiaohong Wu, MD","86-0571-85893111","drxhwu@163.com",{"name":268,"role":112,"phone":11,"phoneExt":11,"email":11},{"facility":273,"status":94,"city":274,"state":259,"zip":275,"country":98,"countryCode":99,"cosmosGeoPoint":276,"geoPoint":280,"contacts":281},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","325000",{"type":101,"coordinates":277},[278,279],120.66682,27.99942,{"lat":279,"lon":278},[282,286],{"name":283,"role":88,"phone":284,"phoneExt":11,"email":285},"Hong Zhu, MD","86-0577-55579999","zhuhong@wmn.edu.cn",{"name":283,"role":112,"phone":11,"phoneExt":11,"email":11},{"type":288,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100632696","ascend-1-lifestyle-intervention-plus-mazdutide-for-weight-management-100632696",false,"NCT07517042","ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management","Achieving Sustained Weight Control Via Exercise, Nutrition & Drugs (Mazdutide) (ASCEND- 1 Trial)","Inclusion Criteria:\n\n* Adult men or women aged 18 years or older;\n* Simple obesity, defined as a body mass index (BMI) of 28.0-45.0 kg\u002Fm²;\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Active pulmonary tuberculosis, malignant tumors, human immunodeficiency virus (HIV) infection, or other serious infectious or systemic diseases;\n* Severe hepatic impairment (aspartate aminotransferase \\[AST\\] or alanine aminotransferase \\[ALT\\] \\>3 times the upper limit of normal), severe renal impairment, or end-stage renal disease (estimated glomerular filtration rate \\[eGFR\\] \\\u003C30 mL\u002Fmin\u002F1.73 m²);\n* Severe cardiovascular diseases, including angina pectoris, myocardial infarction, or stroke within the past 6 months;\n* Severe gastrointestinal diseases, or a history of gastrointestinal resection surgery within the past year;\n* Acute or chronic pancreatitis, gallbladder disease, or pancreatic injury;\n* Obesity secondary to other causes, including Cushing's syndrome, primary hypothyroidism, hypothalamic obesity, or acromegaly; drug-induced obesity, such as obesity related to the use of antipsychotic agents or glucocorticoids;\n* Current smoker or habitual smoking within the past 3 months;\n* Current use of other weight-loss medications or a history of bariatric surgery;\n* Previously diagnosed diabetes mellitus or current use of glucose-lowering medications;\n* Pregnant or breastfeeding women, or women planning pregnancy during the study period;\n* Inability to complete a 2-year follow-up due to health conditions, relocation, or other reasons;\n* Any other condition deemed by the investigator to make the participant unsuitable for participation in the study.","ALL","18 Years",{"count":299,"type":300},420,"ESTIMATED","INTERVENTIONAL",[303],"NA","Obesity is a chronic, progressive, and relapsing disease. Although lifestyle interventions and anti-obesity medications are effective for inducing weight loss, evidence regarding their role in long-term weight maintenance after pharmacologically induced weight reduction remains limited. In addition, the high cost and potential adverse effects of weight-loss medications restrict their prolonged use, and it is unclear whether low dose medication, intensive life style intervention or together can serve as an effective strategy for weight maintenance.\n\nThis randomized controlled trial aims to evaluate the effectiveness of a 1-year intensive lifestyle intervention, a reduced dose of mazdutide (3.0 mg once weekly), or their combination in weight maintenance among individuals with obesity who have achieved initial weight loss after intensive treatment with high dose mazdutide. The study seeks to provide high-quality clinical evidence to inform long-term weight maintenance strategies after weight loss in patients with obesity.",[306,307],"Obesity","Weight Control",[309,310,311,312,313],"obesity","GLP-1 RA","Exercise","Nutrition","Sustained weight Control","2026-09-13",{"date":316,"type":317},"2026-09-15","ACTUAL",{"date":319,"type":317},"2026-06-10",{"date":321,"type":300},"2028-12",{"name":5,"class":6},13]