[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100650086":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":40,"responsibleParty":59,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Augusta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","a look-alike tablet to the intervention that contains no EVOO-phenolics",[13],"Dietary Supplement: Placebo",{"label":15,"type":16,"description":15,"interventionNames":17},"EVOO phenolics","ACTIVE_COMPARATOR",[18],"Dietary Supplement: EVOO-phenolics dietary supplement",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","EVOO-phenolics dietary supplement","EVOO phenolic dietary supplement which is standardized to contain10 mg of EVOO total phenolics",[15],null,{"type":21,"name":9,"description":9,"armGroupLabels":27,"otherNames":25},[9],[29],{"name":30,"affiliation":5,"role":31},"Amal Kaddoumi, PhD","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":25,"email":36},"CONTACT","7067234439","akaddoumi@augusta.edu",{"name":38,"role":34,"phone":39,"phoneExt":25,"email":36},"Ryan Harris, PhD","706.721.5998",[41],{"facility":42,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Georgia prevention institute","Augusta","Georgia","30912","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-81.97484,33.47097,{"lat":52,"lon":51},[55],{"name":56,"role":34,"phone":57,"phoneExt":25,"email":58},"Jacob Looney, MS","(706)-721-5483","jlooney@augusta.edu",{"type":60,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100650086","assessing-treatment-with-high-phenolic-evoo-supplements-for-neurovascular-activity-100650086",false,"NCT07741773","Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity","Dietary Supplementation With EVOO Phenolics Prevents MCI Progression to Alzheimer's Disease","ATHENA","Inclusion Criteria:\n\n* CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.\n\nExclusion Criteria:\n\n* History or presence of vascular disease that may affect cognitive function\n* History or presence of stroke within the past 1 year\n* Recent transient ischemic attack (TIA) within the past 180 days\n* History of severe, clinically significant CNS trauma\n* History of intracranial tumor\n* History or presence of kidney disease (eGFR \\\u003C60 mL\u002Fmin\u002F1.73m2)\n* Presence of a pacemaker\n* Presence of metal in the body\n* Allergic to the MRI contrast agent \"Multihance\"\n* Pregnancy","ALL","50 Years","70 Years",{"count":73,"type":74},20,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:\n\n* Does dietary supplementation with EVOO phenolics improve cognitive function?\n* What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?\n\nResearchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)\n\nParticipants will:\n\n* Take EVOO dietary supplements or a placebo daily for 6 months\n* Visit the study site during the 6-month study for screening and testing.",[80],"Mild Cognitive Impairment (MCI)",[82,83,84,85],"Olive oil","Cognitive function","Cerebrovascular function","MCI","NOT_YET_RECRUITING","2026-07-27",{"date":89,"type":90},"2026-08-03","ACTUAL",{"date":92,"type":74},"2026-09-01",{"date":94,"type":74},"2028-08-31",{"name":5,"class":6},1]