[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654688":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":33,"studyPopulation":25,"armGroups":34,"interventions":40,"overallOfficials":46,"centralContacts":54,"locations":62,"responsibleParty":75,"collaborators":25,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":25,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":25,"studyType":93,"phases":94,"briefSummary":95,"conditions":96,"keywords":103,"overallStatus":110,"whyStopped":25,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":25},[9],{"measure":10,"description":11,"timeFrame":12},"Heart rate variability HRV during descent and re-ascent","Difference\u002Fchange in heart rate variability at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals","From day of descent (day 1) and day of re-ascent (day 8)",[14,17,20,22],{"measure":15,"description":16,"timeFrame":12},"SpO2 during descent and re-ascent","Difference\u002Fchange in SpO2 at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals",{"measure":18,"description":19,"timeFrame":12},"ECG-Repolarization during descent and re-ascent","Occurrence\u002Fchanges in cardial arrhythmias at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals",{"measure":21,"description":19,"timeFrame":12},"Cardial arrhythmias during descent and re-ascent",{"measure":23,"description":24,"timeFrame":12},"Pulse transit time during descent and re-ascent","Occurrence and difference\u002Fchange in pulse transit time (drops) at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in healthy individuals",null,{"allocation":27,"interventionModel":28,"interventionModelDescription":29,"primaryPurpose":30,"observationalModel":25,"timePerspective":25,"maskingInfo":31},"NA","SINGLE_GROUP","Healthy participants living permanently \\> 2600m around Quito (Ecuador) will be assessed during descent from 2850m to sea level and during re-ascent after one week from sea level to 2850m","SUPPORTIVE_CARE",{"masking":32,"maskingDescription":25,"whoMasked":25},"NONE","The aim of this research is to investigate the heart rate variability and other hemodynamic outcomes during the descent from 2850m to sea level and during re-ascent from sea level to 2850m in healthy individuals, who permanently live at high altitude over 2600m",[35],{"label":10,"type":36,"description":37,"interventionNames":38},"EXPERIMENTAL","Assessment of heart rate variability and other hemodynamic outcomes in healthy individuals during descent from 2850m to sea level and during re-ascent from sea level (after one week stay) back to their living altitude at 2850m",[39],"Behavioral: Descent and re-ascent (2850m, sea level)",[41],{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":25},"BEHAVIORAL","Descent and re-ascent (2850m, sea level)","Descent from 2850m to sea level (in one day by bus) and re-ascent after 7 days from sea level to 2850m (in one day by bus)",[10],[47,51],{"name":48,"affiliation":49,"role":50},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":52,"affiliation":53,"role":50},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[55,60],{"name":56,"role":57,"phone":58,"phoneExt":25,"email":59},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":61,"role":57,"phone":58,"phoneExt":25,"email":25},"Michael Furian, Prof. Dr. sc. ETH",[63],{"facility":64,"status":25,"city":65,"state":25,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":25},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":70,"coordinates":71},"Point",[72,73],8.55,47.36667,{"lat":73,"lon":72},{"type":76,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654688","assessment-of-heart-rate-variability-hrv-during-descent-de-from-2850m-to-sea-level-and-during-re-ascent-a-from-sea-level-to-2850m-in-healthy-individuals-h-100654688",false,"NCT07801846","Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adults aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* healthy: no self perceived cardiopulmonary disease limiting daily activities\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* Participants who cannot follow the study investigations\n* Participants permanently living \\\u003C 2600m\n* Participants who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* any self-perceived cardiopulmonary disease limiting daily activities",true,"ALL","18 Years","80 Years",{"count":91,"type":92},14,"ESTIMATED","INTERVENTIONAL",[27],"To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in healthy individuals, who live permanently \\>2600m.",[97,98,99,100,101,102],"Healthy","Healthy Adult","High Altitude Effects","High Altitude","Heart Rate Variability (HRV)","ECG Abnormalities",[104,105,106,107,108,109],"Health","High altitude","Heart rate variability","ECG","Arrhythmias","Pulse transit time","NOT_YET_RECRUITING","2026-08-31",{"date":113,"type":114},"2026-09-03","ACTUAL",{"date":116,"type":92},"2026-09-25",{"date":118,"type":92},"2026-12-31",{"name":77,"class":6},1]