[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654618":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":34,"studyPopulation":26,"armGroups":35,"interventions":41,"overallOfficials":47,"centralContacts":55,"locations":63,"responsibleParty":76,"collaborators":26,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":26,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":26,"studyType":93,"phases":94,"briefSummary":95,"conditions":96,"keywords":103,"overallStatus":112,"whyStopped":26,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":26},[9],{"measure":10,"description":11,"timeFrame":12},"Heart rate variability HRV during descent and re-ascent","Difference\u002Fchange in heart rate variability at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in patients with pulmonary arterial hypertension","From day of descent (day 1) and day of re-ascent (day 8)",[14,17,20,23],{"measure":15,"description":16,"timeFrame":12},"SpO2 during descent and re-ascent","Difference\u002Fchange in SpO2 at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in patients with pulmonary arterial hypertension",{"measure":18,"description":19,"timeFrame":12},"ECG-Repolarization during descent and re-ascent","Difference\u002Fchange in ECG-repolarization at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in patients with pulmonary arterial hypertension",{"measure":21,"description":22,"timeFrame":12},"Cardial arrhythmias during descent and re-ascent","Occurrence\u002Fchanges in cardial arrhythmias at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in patients with pulmonary arterial hypertension",{"measure":24,"description":25,"timeFrame":12},"Pulse transit time during descent and re-ascent","Occurrence and difference\u002Fchange in pulse transit time (drops) at different altitudes during descent (2850m to sea level) and during re-ascent after 7 days (sea level to 2850m) in patients with pulmonary arterial hypertension",null,{"allocation":28,"interventionModel":29,"interventionModelDescription":30,"primaryPurpose":31,"observationalModel":26,"timePerspective":26,"maskingInfo":32},"NA","SINGLE_GROUP","Patients with pulmonary arterial hypertension living permanently \\> 2600m around Quito (Ecuador) will be assessed during descent from 2850m to sea level and during re-ascent after one week from sea level to 2850m","SUPPORTIVE_CARE",{"masking":33,"maskingDescription":26,"whoMasked":26},"NONE","The aim of this research is to investigate the heart rate variability and other hemodynamic outcomes during the descent from 2850m to sea level and during re-ascent from sea level to 2850m in patients with diagnosed pulmonary arterial hypertension according to guidelines, who permanently live at high altitude over 2600m",[36],{"label":10,"type":37,"description":38,"interventionNames":39},"EXPERIMENTAL","Assessment of heart rate variability and other hemodynamic outcomes in patients with pulmonary arterial disease during descent from 2850m to sea level and during re-ascent from sea level (after one week stay) back near their living altitude at 2850m",[40],"Behavioral: Descent and re-ascent (2850m, sea level)",[42],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":26},"BEHAVIORAL","Descent and re-ascent (2850m, sea level)","Descent from 2850m to sea level (in one day by bus) and re-ascent after 7 days from sea level to 2850m (in one day by bus)",[10],[48,52],{"name":49,"affiliation":50,"role":51},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":53,"affiliation":54,"role":51},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[56,61],{"name":57,"role":58,"phone":59,"phoneExt":26,"email":60},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":62,"role":58,"phone":59,"phoneExt":26,"email":26},"Michael Furian, Prof. Dr. sc. ETH",[64],{"facility":65,"status":26,"city":66,"state":26,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":26},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":71,"coordinates":72},"Point",[73,74],8.55,47.36667,{"lat":74,"lon":73},{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654618","assessment-of-heart-rate-variability-hrv-during-descent-de-from-2850m-to-sea-level-and-during-re-ascent-a-from-sea-level-to-2850m-in-patients-with-pulmonary-arterial-hypertension-pah-100654618",false,"NCT07801859","Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Patients With Pulmonary Arterial Hypertension PAH","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adult patients aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines\n* Patients are stable on therapy\n* NYHA (new york heart association) functional class I-III.\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* unstable condition\n* Patients who cannot follow the study investigations\n* Patient permanently living \\\u003C 2600m.\n* Patients who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* Patients with moderate to severe concomitant lung disease (FEV1\\\u003C70% or forced vital capacity \\\u003C70%), severe parenchymal lung disease, severe smokers (\\>20 cigarettes\u002Fday)\n* Severely hypoxemic patients at Quito permanently having persistent SpO2 (oxygen saturation by pulseoximetry) \\\u003C80% on ambient air.\n* Patient with a non-corrected ventricular septum defect\n* Relevant concomitant other disease of the heart, kidney, liver, blood (anemia hemoglobin\\\u003C11 g\u002Fdl)","ALL","18 Years","80 Years",{"count":91,"type":92},20,"ESTIMATED","INTERVENTIONAL",[28],"To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in patients with pulmonary arterial hypertension PAH, who live permanently \\>2600m.",[97,98,99,100,101,102],"High Altitude Effects","High Altitude","Pulmonary Vascular Disease","Pulmonary Arterial Hypertension (PAH)","Heart Rate Variability (HRV)","ECG Abnormalities",[104,105,106,107,108,109,110,111],"Pulmonary hypertension","Pulmonary arterial hypertension PAH","Pulmonary vascular disease","High altitude","Heart rate variability","ECG","Arrythmias","Pulse transit time","NOT_YET_RECRUITING","2026-08-31",{"date":115,"type":116},"2026-09-03","ACTUAL",{"date":118,"type":92},"2026-09-25",{"date":120,"type":92},"2026-12-31",{"name":78,"class":6},1]