[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654869":3},{"organization":4,"outcomesModule":7,"designInfo":68,"detailedDescription":75,"studyPopulation":67,"armGroups":76,"interventions":83,"overallOfficials":89,"centralContacts":97,"locations":105,"responsibleParty":118,"collaborators":67,"id":122,"slug":123,"hasResults":124,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":67,"eligibilityCriteria":128,"healthyVolunteers":124,"sex":129,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":67,"studyType":135,"phases":136,"briefSummary":137,"conditions":138,"keywords":145,"overallStatus":150,"whyStopped":67,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":160},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":67},[9],{"measure":10,"description":11,"timeFrame":12},"FEV1 after re-ascent to 2850m","Difference\u002Fchange in forced expiratory volume in one second FEV1 between sea level (measurement on the 4th day) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension","From Day 4 at sea level to the day after re-ascent (Day 9: approximately 6 days)",[14,17,20,23,26,29,33,36,39,42,45,48,52,55,58,61,64],{"measure":15,"description":16,"timeFrame":12},"Forced Vital Capacity FVC after re-ascent to 2850m","Difference\u002Fchange in forced vital capacity FVC between sea level (measurement on the 4th day) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":18,"description":19,"timeFrame":12},"FEV1\u002FFVC after re-ascent to 2850m","Difference\u002Fchange in FEV1\u002FFVC between sea level (measurement on the 4th day) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":21,"description":22,"timeFrame":12},"Respiratory Impedance (forced oscillation technique) after re-ascent to 2850m","Difference\u002Fchange in respiratory impedance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":24,"description":25,"timeFrame":12},"Respiratory resistance (forced oscillation technique) after re-ascent to 2850m","Difference\u002Fchange in respiratory resistance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":27,"description":28,"timeFrame":12},"Respiratory reactance (forced oscillation technique) after re-ascent to 2850m","Difference\u002Fchange in respiratory reactance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":30,"description":31,"timeFrame":32},"FEV1 after 4 days at sea level","Difference\u002Fchange in FEV1 between 2850m (prior to descent) and day 4 at sea level in patients with pulmonary arterial disease","From high altitude (Day 0, 2850m) to day 4 at sea level (approximately 5 days)",{"measure":34,"description":35,"timeFrame":32},"Forced Vital Capacity FVC after 4 days at sea level","Difference\u002Fchange in forced vital capacity FVC between 2850m (prior to descent) and day 4 at sea level in patients with pulmonary arterial disease",{"measure":37,"description":38,"timeFrame":32},"FEV1\u002FFVC after 4 days at sea level","Difference\u002Fchange in FEV1\u002FFVC between 2850m (prior to descent) and day 4 at sea level in patients with pulmonary arterial disease",{"measure":40,"description":41,"timeFrame":32},"Respiratory Impedance (forced oscillation technique) after 4 days at sea level","Difference\u002Fchange in respiratory impedance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in patients with pulmonary arterial disease",{"measure":43,"description":44,"timeFrame":32},"Respiratory resistance (forced oscillation technique) after 4 days at sea level","Difference\u002Fchange in respiratory resistance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in patients with pulmonary arterial disease",{"measure":46,"description":47,"timeFrame":32},"Respiratory reactance (forced oscillation technique) after 4 days at sea level","Difference\u002Fchange in respiratory reactance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in patients with pulmonary arterial disease",{"measure":49,"description":50,"timeFrame":51},"FEV1 pre-descent and after re-ascent (2850m)","Difference\u002Fchange in FEV1 at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial disease","Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)",{"measure":53,"description":54,"timeFrame":51},"Forced Vital Capacity FVC pre-descent and after re-ascent (2850m)","Difference\u002Fchange in forced vital capacity FVC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":56,"description":57,"timeFrame":51},"FEV1\u002FFVC pre-descent and after re-ascent (2850m)","Difference\u002Fchange in FEV1\u002FFVC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":59,"description":60,"timeFrame":51},"Respiratory Impedance (forced oscillation technique) pre-descent and after re-ascent (2850m)","Difference\u002Fchange in respiratory impedance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":62,"description":63,"timeFrame":51},"Respiratory resistance (forced oscillation technique) pre-descent and after re-ascent (2850m)","Difference\u002Fchange in respiratory resistance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":65,"description":66,"timeFrame":51},"Respiratory reactance (forced oscillation technique) pre-descent and after re-ascent (2850m)","Difference\u002Fchange in respiratory reactance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",null,{"allocation":69,"interventionModel":70,"interventionModelDescription":71,"primaryPurpose":72,"observationalModel":67,"timePerspective":67,"maskingInfo":73},"NA","SINGLE_GROUP","Patients with pulmonary arterial hypertension living permanently \\> 2600m around Quito (Ecuador) will be assessed at 2850m, after relocation to sea level for 7 days and after re-ascent","SUPPORTIVE_CARE",{"masking":74,"maskingDescription":67,"whoMasked":67},"NONE","The aim of this research is to investigate the lung function and pulmonary resistance\u002Freactance before and after re-ascent (sea level for 7 days after prior descent from 2850m vs. re-ascent to 2850m) in patients with diagnosed pulmonary hypertension according to guidelines, who permanently live at high altitude over 2600m.",[77],{"label":78,"type":79,"description":80,"interventionNames":81},"Lung function at sea level and at 2850m","EXPERIMENTAL","Assessment of lung function and pulmonary resistance\u002Freactance on day four at sea level (after prior descent from 2850m) and after re-ascent (after totally one week at sea level) back to 2850m by bus (in one day)",[82],"Behavioral: Re-ascent from sea level to 2850m",[84],{"type":85,"name":86,"description":87,"armGroupLabels":88,"otherNames":67},"BEHAVIORAL","Re-ascent from sea level to 2850m","Descent from 2850m to sea level with a stay for 7 days and re-ascent\u002Freturn back to their usual living altitude at 2850m",[78],[90,94],{"name":91,"affiliation":92,"role":93},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":95,"affiliation":96,"role":93},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[98,103],{"name":99,"role":100,"phone":101,"phoneExt":67,"email":102},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":104,"role":100,"phone":101,"phoneExt":67,"email":67},"Michael Furian, Prof. Dr. sc. ETH",[106],{"facility":107,"status":67,"city":108,"state":67,"zip":109,"country":110,"countryCode":111,"cosmosGeoPoint":112,"geoPoint":117,"contacts":67},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":113,"coordinates":114},"Point",[115,116],8.55,47.36667,{"lat":116,"lon":115},{"type":119,"investigatorFullName":120,"investigatorTitle":121,"investigatorAffiliation":5,"oldNameTitle":67,"oldOrganization":67},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654869","assessment-of-lung-function-lufu-at-sea-level-la-vs-high-altitude-ha-in-patients-with-pulmonary-arterial-hypertension-pah-100654869",false,"NCT07804576","Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Patients With Pulmonary Arterial Hypertension PAH","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adult patients aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines\n* Patients are stable on therapy\n* NYHA (new york heart association) functional class I-III.\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* unstable condition\n* Patients who cannot follow the study investigations\n* Patient permanently living \\\u003C 2600m.\n* Patients who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* Patients with moderate to severe concomitant lung disease (FEV1\\\u003C70% or forced vital capacity \\\u003C70%), severe parenchymal lung disease, severe smokers (\\>20 cigarettes\u002Fday)\n* Severely hypoxemic patients at Quito permanently having persistent SpO2 (oxygen saturation by pulseoximetry) \\\u003C80% on ambient air.\n* Patient with a non-corrected ventricular septum defect\n* Relevant concomitant other disease of the heart, kidney, liver, blood (anemia hemoglobin\\\u003C11 g\u002Fdl)","ALL","18 Years","80 Years",{"count":133,"type":134},20,"ESTIMATED","INTERVENTIONAL",[69],"To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance\u002Freactance in patients with pulmonary arterial disease PAH, who live permanently \\> 2600m.",[139,140,141,142,143,144],"Pulmonary Arterial Hypertension (PAH)","Pulmonary Vascular Disease","High Altitude Effects","High Altitude","Lung Function Testing","Lung Function Changes",[146,147,142,148,149],"Pulmonary arterial hypertension PAH","Pulmonary vascular disease","Lung function","forced oscillation technique","NOT_YET_RECRUITING","2026-08-31",{"date":153,"type":154},"2026-09-04","ACTUAL",{"date":156,"type":134},"2026-09-25",{"date":158,"type":134},"2026-12-31",{"name":120,"class":6},1]