[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645520":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":10,"locations":22,"responsibleParty":41,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Marmara University","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"MIH patients requiring initial periodontal treatment",null,[12],"Procedure: Initial periodontal treatment",{"label":14,"type":10,"description":10,"interventionNames":15},"Patients without MIH requiring initial periodontal treatment",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Initial periodontal treatment","DOS samples will be taken before and after treatment",[9,14],[23],{"facility":24,"status":10,"city":25,"state":26,"zip":27,"country":28,"countryCode":10,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Marmara Üniversitesi Recep Tayyip Erdoğan Külliyesi Sağlık Yerleşkesi, Diş Hekimliği Fakültesi","Istanbul","MALTEPE","34854","Turkey (Türkiye)",{"type":30,"coordinates":31},"Point",[32,33],28.94966,41.01384,{"lat":33,"lon":32},[36],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Betul Sen Yavuz","CONTACT","+905399887646","dtbetulsen@gmail.com",{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100645520","assessment-of-peridontal-inflamatuar-markers-in-mih-100645520",false,"NCT07701642","Assessment of Peridontal Inflamatuar Markers in MIH","Investigation of Periodontal Inflammatory Mediators in Permanent Molars Affected by Molar-incisor Hypomineralization","Inclusion Criteria:\n\n* Systemically healthy children aged 8-13 years (both sexes).\n* Children who demonstrate adequate cooperation for dental treatment and study procedures (Frankl Behavior Rating Scale score ≥3).\n* Study group: Children with molar-incisor hypomineralization (MIH) affecting at least three permanent first molars and requiring initial periodontal treatment for gingivitis.\n* Control group: Children without molar-incisor hypomineralization who require initial periodontal treatment for gingivitis.\n* Presence of gingivitis requiring initial periodontal therapy.\n\nExclusion Criteria:\n\n* Use of antibiotics within the previous 1 month.\n* Radiographic evidence of periodontal destruction.\n* History of periodontal treatment within the previous 3 months.\n* Presence of systemic, chronic, or metabolic diseases.\n* Ongoing active orthodontic treatment.\n* Developmental enamel defects other than molar-incisor hypomineralization.\n* History of premature birth.",true,"ALL","8 Years","13 Years",{"count":55,"type":56},76,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to investigate periodontal inflammatory mediators in systemically healthy children aged 8-13 years with and without molar-incisor hypomineralization (MIH) who require initial periodontal treatment due to gingivitis.\n\nThe main questions it aims to answer are:\n\nAre the levels of periodontal inflammatory mediators in gingival crevicular fluid different between children with MIH and those without MIH? Is the presence and severity of MIH associated with clinical periodontal parameters and dentin hypersensitivity?\n\nResearchers will compare children with MIH to children without MIH to determine whether MIH is associated with changes in periodontal inflammatory mediator levels and periodontal clinical findings.",[60],"Molar-Incisor Hypomineralization (MIH)",[62,63],"periodontal inflammatory markers","first permenant molars","NOT_YET_RECRUITING","2026-07-08",{"date":67,"type":68},"2026-07-14","ACTUAL",{"date":70,"type":56},"2026-07-16",{"date":72,"type":56},"2027-11-01",{"name":5,"class":6},1]