[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654580":3},{"organization":4,"outcomesModule":7,"designInfo":62,"detailedDescription":69,"studyPopulation":61,"armGroups":70,"interventions":77,"overallOfficials":83,"centralContacts":91,"locations":99,"responsibleParty":112,"collaborators":61,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":61,"eligibilityCriteria":122,"healthyVolunteers":123,"sex":124,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":61,"studyType":130,"phases":131,"briefSummary":132,"conditions":133,"keywords":139,"overallStatus":144,"whyStopped":61,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":61},[9],{"measure":10,"description":11,"timeFrame":12},"Six-minute walking distance after 7 days at sea level","Difference\u002Fchange in six-minute walking distance in meter (6MWD) between 2850m and Day 5-7 at sea level in healthy individuals","From high altitude (2850m) to day 5-7 at sea level",[14,17,20,23,26,29,32,36,40,43,46,49,52,55,58],{"measure":15,"description":16,"timeFrame":12},"SpO2 (%) at rest and end-exercise after 7 days at sea level","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise between 2850m and Day 5-7 at sea level in healthy individuals",{"measure":18,"description":19,"timeFrame":12},"Heart rate (beats per minute) at rest and end-exercise after 7 days at sea level","Difference\u002Fchange in heart rate at rest and end-exercise between 2850m and Day 5-7 at sea level in healthy individuals",{"measure":21,"description":22,"timeFrame":12},"Blood pressure (mmHg) at rest and end-exercise after 7 days at sea level","Difference\u002Fchange in blood pressure at rest and end-exercise between 2850m and Day 5-7 at sea level in healthy individuals",{"measure":24,"description":25,"timeFrame":12},"Dyspnea and leg discomfort sensation after 7 days at sea level","Difference\u002Fchange in dyspnea and leg discomfort sensation (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise between 2850m and 5-7 days at sea level in healthy individuals",{"measure":27,"description":28,"timeFrame":12},"NYHA functional class (1-4) after 7 days at sea level","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise between 2850m and 5-7 days at sea level in healthy individuals",{"measure":30,"description":31,"timeFrame":12},"Quality of life after 7 days at sea level","Difference\u002Fchange in quality of life score (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) between 2850m and 5-7 days at sea level in healthy individuals",{"measure":33,"description":34,"timeFrame":35},"General well-being after 7 days at sea level","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) between 2850m and day 5-7 at sea level in healthy individuals","From high altitude (2850m) to Day 5-7 at sea level",{"measure":37,"description":38,"timeFrame":39},"Acclimatization-effect of six-minute walking distance (m) at sea level","Difference\u002Fchange in six-minute walking distance (6MWD) within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals","From Day 2 to Day 5-7 at sea level",{"measure":41,"description":42,"timeFrame":39},"Acclimatization-Effect of SpO2 (%) at rest and end-exercise at sea level","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals",{"measure":44,"description":45,"timeFrame":39},"Acclimatization-Effect of heart rate (beats per minute) at rest and end-exercise at sea level","Difference\u002Fchange in heart rate at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals",{"measure":47,"description":48,"timeFrame":39},"Acclimatization-Effect of blood pressure (mmHg) at rest and end-exercise at sea level","Difference\u002Fchange in blood pressure at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals",{"measure":50,"description":51,"timeFrame":39},"Acclimatization-Effect of dyspnea and leg discomfort at sea level","Difference\u002Fchange in dyspnea and leg discomfort (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in healthy individuals",{"measure":53,"description":54,"timeFrame":39},"Acclimatization-Effect of NYHA functional class (1-4) at sea level","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise within a stay of 7 days at sea level (after descent from 2850m) in healthy individuals",{"measure":56,"description":57,"timeFrame":39},"Acclimatization-Effect of Quality of Life at sea level","Difference\u002Fchange in quality of life (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) within a stay of 7 days at sea level (after descent from 2850m) in healthy individuals",{"measure":59,"description":60,"timeFrame":39},"Acclimatization-Effect of general well-being at sea level","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) within a stay of 7 days at sea level (after descent from 2850m) in healthy individuals",null,{"allocation":63,"interventionModel":64,"interventionModelDescription":65,"primaryPurpose":66,"observationalModel":61,"timePerspective":61,"maskingInfo":67},"NA","SINGLE_GROUP","Healthy individuals living permanently \\> 2600m around Quito (Ecuador) will be assessed at 2850m and after descent to sea level","SUPPORTIVE_CARE",{"masking":68,"maskingDescription":61,"whoMasked":61},"NONE","The aim of this research is to investigate the six-minute walking distance and scores before and after descent (high altitude near their living altitude vs. sea level) in healthy individuals, who permanently live at high altitude over 2600m.",[71],{"label":72,"type":73,"description":74,"interventionNames":75},"Six-minute walking distance 6MWD at sea level","EXPERIMENTAL","Assessment of the six-minute walking distance and scores near their resident altitude at 2850m followed by a descent from 2850m to sea level by bus with a stay for 7 days and again assessment of the same outcomes",[76],"Behavioral: Descent from 2850m to sea level",[78],{"type":79,"name":80,"description":81,"armGroupLabels":82,"otherNames":61},"BEHAVIORAL","Descent from 2850m to sea level","Descent from 2850m to sea level with stay for 7 days",[72],[84,88],{"name":85,"affiliation":86,"role":87},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":89,"affiliation":90,"role":87},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[92,97],{"name":93,"role":94,"phone":95,"phoneExt":61,"email":96},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":98,"role":94,"phone":95,"phoneExt":61,"email":61},"Michael Furian, Prof. Dr. sc. ETH",[100],{"facility":101,"status":61,"city":102,"state":61,"zip":103,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":111,"contacts":61},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":107,"coordinates":108},"Point",[109,110],8.55,47.36667,{"lat":110,"lon":109},{"type":113,"investigatorFullName":114,"investigatorTitle":115,"investigatorAffiliation":5,"oldNameTitle":61,"oldOrganization":61},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654580","assessment-of-six-minute-walking-distance-6mwd-between-high-altitude-ha-vs-sea-level-la-in-healthy-individuals-h-100654580",false,"NCT07801872","Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Healthy Individuals H","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adults aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* healthy: no self-perceived cardiopulmonary disease limiting daily activities\n* written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* Participants who cannot follow the study investigations\n* Participants permanently living \\\u003C 2600m\n* Participants who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* any self-perceived cardiopulmonary disease limiting daily activities",true,"ALL","18 Years","80 Years",{"count":128,"type":129},14,"ESTIMATED","INTERVENTIONAL",[63],"To study the effect of descent from high altitude (Quito Ecuador: 2850m) to sea level on six-minute walking distance and scores in healthy individuals, who live permanently \\>2600m.",[134,135,136,137,138],"High Altitude","Six-minute Walk Test","High Altitude Effects","Healthy","Healthy Adult",[140,141,142,143],"six-minute walking distance","high altitude","hypoxia","NYHA","NOT_YET_RECRUITING","2026-08-31",{"date":147,"type":148},"2026-09-03","ACTUAL",{"date":150,"type":129},"2026-09-25",{"date":152,"type":129},"2026-12-31",{"name":114,"class":6},1]