[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654861":3},{"organization":4,"outcomesModule":7,"designInfo":62,"detailedDescription":69,"studyPopulation":61,"armGroups":70,"interventions":77,"overallOfficials":83,"centralContacts":91,"locations":99,"responsibleParty":112,"collaborators":61,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":61,"eligibilityCriteria":122,"healthyVolunteers":118,"sex":123,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":61,"studyType":129,"phases":130,"briefSummary":131,"conditions":132,"keywords":138,"overallStatus":144,"whyStopped":61,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":61},[9],{"measure":10,"description":11,"timeFrame":12},"Six-minute walking distance (m) after 7 days at sea level","Difference\u002Fchange in six-minute walking distance 6MWD between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension","From high altitude (2850m) to day 5-7 at sea level",[14,17,20,23,26,29,32,36,40,43,46,49,52,55,58],{"measure":15,"description":16,"timeFrame":12},"SpO2 (peripheral oxygen saturation, %) at rest and end-exercise after 7 days at sea level","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":18,"description":19,"timeFrame":12},"Heart rate (beats per minute) at rest and end-exercise after 7 days at sea level","Difference\u002Fchange in heart rate at rest and end-exercise between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":21,"description":22,"timeFrame":12},"Blood pressure (mmHg) at rest and end-exercise after 7 days at sea level","Difference\u002Fchange in blood pressure at rest and end-exercise between 2850m and Day 5-7 at sea level in patients with pulmonary arterial hypertension",{"measure":24,"description":25,"timeFrame":12},"Dyspnea and leg discomfort sensation after 7 days at sea level","Difference\u002Fchange in dyspnea and leg discomfort sensation (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise between 2850m and 5-7 days at sea level in patients with pulmonary arterial hypertension",{"measure":27,"description":28,"timeFrame":12},"NYHA functional class (1-4) after 7 days at sea level","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise between 2850m and 5-7 days at sea level in patients with pulmonary arterial hypertension",{"measure":30,"description":31,"timeFrame":12},"Quality of life after 7 days at sea level","Difference\u002Fchange in quality of life score (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) between 2850m and 5-7 days at sea level in patients with pulmonary arterial hypertension",{"measure":33,"description":34,"timeFrame":35},"General well-being after 7 days at sea level","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) between 2850m and day 5-7 at sea level in patients with pulmonary arterial hypertension","From high altitude (2850m) to Day 5-7 at sea level",{"measure":37,"description":38,"timeFrame":39},"Acclimatization-effect of six-minute walking distance (m) at sea level","Difference\u002Fchange in six-minute walking distance (6MWD) within a stay at sea level of 7 days (after descent from 2850m) in patients with pulmonary arterial hypertension","From Day 2 to Day 5-7 at sea level",{"measure":41,"description":42,"timeFrame":39},"Acclimatization-Effect of SpO2 (%) at rest and end-exercise at sea level","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in patients with pulmonary arterial hypertension",{"measure":44,"description":45,"timeFrame":39},"Acclimatization-Effect of heart rate (beats per minute) at rest and end-exercise at sea level","Difference\u002Fchange in heart rate at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in patients with pulmonary arterial hypertension",{"measure":47,"description":48,"timeFrame":39},"Acclimatization-Effect of blood pressure (mmHg) at rest and end-exercise at sea level","Difference\u002Fchange in blood pressure at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in patients with pulmonary arterial hypertension",{"measure":50,"description":51,"timeFrame":39},"Acclimatization-Effect of dyspnea and leg discomfort at sea level","Difference\u002Fchange in dyspnea and leg discomfort (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise within a stay at sea level of 7 days (after descent from 2850m) in patients with pulmonary arterial hypertension",{"measure":53,"description":54,"timeFrame":39},"Acclimatization-Effect of NYHA functional class (1-4) at sea level","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise within a stay of 7 days at sea level (after descent from 2850m) in patients with pulmonary arterial hypertension",{"measure":56,"description":57,"timeFrame":39},"Acclimatization-Effect of Quality of Life at sea level","Difference\u002Fchange in quality of life (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) within a stay of 7 days at sea level (after descent from 2850m) in patients with pulmonary arterial hypertension",{"measure":59,"description":60,"timeFrame":39},"Acclimatization-Effect of general well-being at sea level","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) within a stay of 7 days at sea level (after descent from 2850m) in patients with pulmonary arterial hypertension",null,{"allocation":63,"interventionModel":64,"interventionModelDescription":65,"primaryPurpose":66,"observationalModel":61,"timePerspective":61,"maskingInfo":67},"NA","SINGLE_GROUP","Patients diagnosed with pulmonary arterial hypertension living permanently \\> 2600m around Quito (Ecuador) will be assessed at 2850m and after descent to sea level","SUPPORTIVE_CARE",{"masking":68,"maskingDescription":61,"whoMasked":61},"NONE","The aim of this research is to investigate the six-minute walking distance and scores before and after descent (high altitude near their living altitude vs. sea level) in patients with diagnosed pulmonary arterial hypertension according to guidelines, who permanently live at high altitude over 2600m.",[71],{"label":72,"type":73,"description":74,"interventionNames":75},"Six-minute walking distance 6MWD at 2850m and at sea level","EXPERIMENTAL","Assessment of the six-minute walking distance and scores near their resident altitude at 2850m followed by a descent from 2850m to sea level by bus with a stay for 7 days and again assessment of the same outcomes",[76],"Behavioral: Descent from 2850m to sea level",[78],{"type":79,"name":80,"description":81,"armGroupLabels":82,"otherNames":61},"BEHAVIORAL","Descent from 2850m to sea level","Descent from 2850m to sea level with stay for 7 days",[72],[84,88],{"name":85,"affiliation":86,"role":87},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":89,"affiliation":90,"role":87},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[92,97],{"name":93,"role":94,"phone":95,"phoneExt":61,"email":96},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":98,"role":94,"phone":95,"phoneExt":61,"email":61},"Michael Furian, Prof. Dr. sc. ETH",[100],{"facility":101,"status":61,"city":102,"state":61,"zip":103,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":111,"contacts":61},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":107,"coordinates":108},"Point",[109,110],8.55,47.36667,{"lat":110,"lon":109},{"type":113,"investigatorFullName":114,"investigatorTitle":115,"investigatorAffiliation":5,"oldNameTitle":61,"oldOrganization":61},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654861","assessment-of-six-minute-walking-distance-6mwd-between-high-altitude-ha-vs-sea-level-la-in-patients-with-pulmonary-arterial-hypertension-pah-100654861",false,"NCT07804472","Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adult patients aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines\n* Patients are stable on therapy\n* NYHA (new york heart association) functional class I-III\n* written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* unstable condition\n* Patients who cannot follow the study investigations\n* Patient permanently living \\\u003C 2600m\n* Patients who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks\n* Patients with moderate to severe concomitant lung disease (FEV1\\\u003C70% or forced vital capacity \\\u003C70%), severe parenchymal lung disease, severe smokers (\\>20 cigarettes\u002Fday)\n* Severely hypoxemic patients at Quito: permanently having persistent SpO2 (oxygen saturation by pulse-oximetry) \\\u003C80% on ambient air.\n* Patient with a non-corrected ventricular septum defect\n* Relevant concomitant other disease of the heart, kidney, liver, blood (anemia hemoglobin\\\u003C11 g\u002Fdl)","ALL","18 Years","80 Years",{"count":127,"type":128},20,"ESTIMATED","INTERVENTIONAL",[63],"To study the effect of relocation from high altitude (Quito: 2850m) to sea level on six-minute walking distance and scores in patients with pulmonary arterial hypertension PAH, who live permanently \\>2600m.",[133,134,135,136,137],"Pulmonary Arterial Hypertension (PAH)","Pulmonary Vascular Disease","Six-minute Walk Test","High Altitude Effects","High Altitude",[139,137,140,141,142,143],"Hypoxia","Pulmonary Hypertension","6-minute walking distance","Pulmonary Arterial Hypertension","NYHA","NOT_YET_RECRUITING","2026-08-31",{"date":147,"type":148},"2026-09-04","ACTUAL",{"date":150,"type":128},"2026-09-25",{"date":152,"type":128},"2026-12-31",{"name":114,"class":6},1]