[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654300":3},{"organization":4,"outcomesModule":7,"designInfo":61,"detailedDescription":68,"studyPopulation":60,"armGroups":69,"interventions":76,"overallOfficials":82,"centralContacts":90,"locations":98,"responsibleParty":110,"collaborators":60,"id":114,"slug":115,"hasResults":116,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":60,"eligibilityCriteria":120,"healthyVolunteers":121,"sex":122,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":60,"studyType":128,"phases":129,"briefSummary":130,"conditions":131,"keywords":137,"overallStatus":144,"whyStopped":60,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":60},[9],{"measure":10,"description":11,"timeFrame":12},"Six-minute walking distance after re-ascent to 2850m","Difference\u002Fchange in six-minute walking distance 6MWD between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals","From Day 5-7 at sea level to the day after re-ascent",[14,17,20,23,26,29,32,35,39,42,45,48,51,54,57],{"measure":15,"description":16,"timeFrame":12},"SpO2 at rest and end-exercise after re-ascent to 2850m","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals",{"measure":18,"description":19,"timeFrame":12},"Heart rate at rest and end-exercise after re-ascent to 2850m","Difference\u002Fchange in heart rate at rest and end-exercise between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals",{"measure":21,"description":22,"timeFrame":12},"Blood pressure at rest and end-exercise after re-ascent to 2850m","Difference\u002Fchange in blood pressure at rest and end-exercise between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals",{"measure":24,"description":25,"timeFrame":12},"Dyspnea and leg discomfort sensation after re-ascent to 2850m","Difference\u002Fchange in dyspnea and leg discomfort sensation (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals",{"measure":27,"description":28,"timeFrame":12},"NYHA functional class after re-ascent to 2850m","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals",{"measure":30,"description":31,"timeFrame":12},"Quality of life after re-ascent to 2850m","Difference\u002Fchange in quality of life score (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals",{"measure":33,"description":34,"timeFrame":12},"General well-being after re-ascent to 2850m","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals",{"measure":36,"description":37,"timeFrame":38},"Six-minute walking test pre-descent to after re-ascent","Difference\u002Fchange in six-minute walking distance (6MWD) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals","Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)",{"measure":40,"description":41,"timeFrame":38},"SpO2 at rest and end-exercise pre-descent to after re-ascent","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",{"measure":43,"description":44,"timeFrame":38},"Heart rate at rest and end-exercise pre-descent to after re-ascent","Difference\u002Fchange in heart rate at rest and end-exercise with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",{"measure":46,"description":47,"timeFrame":38},"Blood pressure at rest and end-exercise pre-descent to after re-ascent","Difference\u002Fchange in blood pressure at rest and end-exercise with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",{"measure":49,"description":50,"timeFrame":38},"Dyspnea and leg discomfort pre-descent to after re-ascent","Difference\u002Fchange in dyspnea and leg discomfort (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",{"measure":52,"description":53,"timeFrame":38},"NYHA functional class pre-descent to after re-ascent","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",{"measure":55,"description":56,"timeFrame":38},"Quality of life pre-descent to after re-ascent","Difference\u002Fchange in quality of life (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",{"measure":58,"description":59,"timeFrame":38},"General well-being pre-descent to after re-ascent","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals",null,{"allocation":62,"interventionModel":63,"interventionModelDescription":64,"primaryPurpose":65,"observationalModel":60,"timePerspective":60,"maskingInfo":66},"NA","SINGLE_GROUP","Healthy individuals living permanently \\> 2600m around Quito (Ecuador) will be assessed after 7 days at sea level and after re-ascent to 2850m","SUPPORTIVE_CARE",{"masking":67,"maskingDescription":60,"whoMasked":60},"NONE","The aim of this research is to investigate the six-minute walking distance and other scores before and after re-ascent (sea level for 7 days vs. re-ascent to 2850m) in healthy individuals, who permanently live at high altitude over 2600m.",[70],{"label":71,"type":72,"description":73,"interventionNames":74},"SIx-minute walking distance 6MWD after re-ascent at 2850m","EXPERIMENTAL","Assessment of six-minute walking distance 6MWD and other scores after 7 days at sea level with re-ascent from sea level back to 2850m by bus (in one day) and assessments of the same outcomes",[75],"Behavioral: Re-Ascent sea level to 2850m",[77],{"type":78,"name":79,"description":80,"armGroupLabels":81,"otherNames":60},"BEHAVIORAL","Re-Ascent sea level to 2850m","After 7 days at sea level return\u002Fre-ascent to their usual living altitude at 2850m",[71],[83,87],{"name":84,"affiliation":85,"role":86},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":88,"affiliation":89,"role":86},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[91,96],{"name":92,"role":93,"phone":94,"phoneExt":60,"email":95},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":97,"role":93,"phone":94,"phoneExt":60,"email":60},"Michael Furian, Prof. Dr. sc. ETH",[99],{"facility":100,"status":60,"city":101,"state":60,"zip":60,"country":102,"countryCode":103,"cosmosGeoPoint":104,"geoPoint":109,"contacts":60},"University Hospital of Zurich","Zurich","Switzerland","CH",{"type":105,"coordinates":106},"Point",[107,108],8.55,47.36667,{"lat":108,"lon":107},{"type":111,"investigatorFullName":112,"investigatorTitle":113,"investigatorAffiliation":5,"oldNameTitle":60,"oldOrganization":60},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654300","assessment-of-six-minute-walking-distance-between-sea-level-la-vs-high-altitude-ha-after-re-ascent-in-healthy-individuals-100654300",false,"NCT07797088","Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adults aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* healthy: no self-perceived cardiopulmonary disease limiting daily activities\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* Participants who cannot follow the study investigations\n* Participants permanently living \\\u003C 2600m\n* Participants who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* any self-perceived cardiopulmonary disease limiting daily activities",true,"ALL","18 Years","80 Years",{"count":126,"type":127},14,"ESTIMATED","INTERVENTIONAL",[62],"To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on six-minute walking distance and other scores in healthy individuals, who live permanently \\>2600m.",[132,133,134,135,136],"High Altitude","Healthy","Healthy Adult","Six-minute Walk Test","High Altitude Effects",[138,139,140,141,142,143],"hypoxia","high altitude","six-minute walking distance","Health","NYHA","Exercise testing","NOT_YET_RECRUITING","2026-08-27",{"date":147,"type":148},"2026-09-01","ACTUAL",{"date":150,"type":127},"2026-09-25",{"date":152,"type":127},"2026-12-31",{"name":112,"class":6},1]