[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100654267":3},{"organization":4,"outcomesModule":7,"designInfo":62,"detailedDescription":69,"studyPopulation":61,"armGroups":70,"interventions":77,"overallOfficials":83,"centralContacts":91,"locations":99,"responsibleParty":112,"collaborators":61,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":61,"eligibilityCriteria":122,"healthyVolunteers":118,"sex":123,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":61,"studyType":129,"phases":130,"briefSummary":131,"conditions":132,"keywords":139,"overallStatus":144,"whyStopped":61,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":154},{"fullName":5,"class":6},"University of Zurich","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":61},[9],{"measure":10,"description":11,"timeFrame":12},"Six-minute walking distance after re-ascent to 2850m","Difference\u002Fchange in six-minute walking distance 6MWD between sea level (after one-week stay) and day after re-ascent at 2850m in patients with pulmonary arterial hypertension","From Day 5-7 at sea level to day after re-ascent",[14,17,20,23,26,29,32,35,39,43,46,49,52,55,58],{"measure":15,"description":16,"timeFrame":12},"SpO2 at rest and end-exercise after re-ascent to 2850m","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise between sea level (after one-week stay) and Day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":18,"description":19,"timeFrame":12},"Heart rate at rest and end-exercise after re-ascent to 2850m","Difference\u002Fchange in heart rate at rest and end-exercise between sea level (after one-week stay) and Day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":21,"description":22,"timeFrame":12},"Blood pressure at rest and end-exercise after re-ascent to 2850m","Difference\u002Fchange in blood pressure at rest and end-exercise between sea level (after one-week stay) and Day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":24,"description":25,"timeFrame":12},"Dyspnea and leg discomfort sensation after re-ascent to 2850m","Difference\u002Fchange in dyspnea and leg discomfort sensation (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise between sea level (after one-week stay) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":27,"description":28,"timeFrame":12},"NYHA functional class after re-ascent to 2850m","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at rest and end-exercise between sea level (after one-week stay) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":30,"description":31,"timeFrame":12},"Quality of life after re-ascent to 2850m","Difference\u002Fchange in quality of life score (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) between sea level (after one-week stay) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":33,"description":34,"timeFrame":12},"General well-being after re-ascent to 2850m","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) between sea level (after one-week stay) and day after re-ascent to 2850m in patients with pulmonary arterial hypertension",{"measure":36,"description":37,"timeFrame":38},"Six-minute walking distance pre-descent to after re-ascent","Difference\u002Fchange in six-minute walking distance (6MWD) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension","Baseline at 2850m followed by a one-week stay at sea level to day after re-ascent back to 2850m (time frame approximately 11 days)",{"measure":40,"description":41,"timeFrame":42},"SpO2 at rest and end-exercise pre-descent to after re-ascent","Difference\u002Fchange in SpO2 (peripheral oxygen saturation) at rest and end-exercise at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension","Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)",{"measure":44,"description":45,"timeFrame":42},"Heart rate at rest and end-exercise pre-descent to after re-ascent","Difference\u002Fchange in heart rate at rest and end-exercise at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":47,"description":48,"timeFrame":42},"Blood pressure at rest and end-exercise pre-descent to after re-ascent","Difference\u002Fchange in blood pressure at rest and end-exercise at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":50,"description":51,"timeFrame":42},"Dyspnea and leg discomfort pre-descent to after re-ascent","Difference\u002Fchange in dyspnea and leg discomfort (assessed with BORG-CR10-Scale, Category Rating 0-10 with 10 being the most dyspnea\u002Fleg discomfort) at rest and end-exercise at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":53,"description":54,"timeFrame":42},"NYHA functional class pre-descent to after re-ascent","Difference\u002Fchange in NYHA functional class (New York Heart Association Class I-IV, IV being the worst) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":56,"description":57,"timeFrame":42},"Quality of life pre-descent to after re-ascent","Difference\u002Fchange in quality of life (EmPHasis-10: Score with 10 questions and 0-50 points, higher scores indicating poorer quality of life) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",{"measure":59,"description":60,"timeFrame":42},"General well-being pre-descent to after re-ascent","Difference\u002Fchange in general well-being (Visual Analog Scale 10cm: the higher, the worse) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in patients with pulmonary arterial hypertension",null,{"allocation":63,"interventionModel":64,"interventionModelDescription":65,"primaryPurpose":66,"observationalModel":61,"timePerspective":61,"maskingInfo":67},"NA","SINGLE_GROUP","Patients diagnosed with pulmonary arterial hypertension living permanently \\> 2600m around Quito (Ecuador) will be assessed after 7 days at sea level and after re-ascent to 2850m","SUPPORTIVE_CARE",{"masking":68,"maskingDescription":61,"whoMasked":61},"NONE","The aim of this research is to investigate the six-minute walking distance and other scores before and after re-ascent (sea level for 7 days vs. re-ascent to 2850m) in patients with diagnosed pulmonary arterial hypertension according to guidelines, who permanently live at high altitude over 2600m.",[71],{"label":72,"type":73,"description":74,"interventionNames":75},"Six-minute walking distance 6MWD at sea level and after re-ascent at 2850m","EXPERIMENTAL","Assessment of six-minute walking distance 6MWD and other scores after 7 days at sea level and after re-ascent from sea level back to 2850m by bus (in one day)",[76],"Behavioral: Re-Ascent sea level to 2850m",[78],{"type":79,"name":80,"description":81,"armGroupLabels":82,"otherNames":61},"BEHAVIORAL","Re-Ascent sea level to 2850m","After 7 days at sea level return\u002Fre-ascent to their usual living altitude at 2850m",[72],[84,88],{"name":85,"affiliation":86,"role":87},"Silvia Ulrich","University Hospital Zurich, Departement of Pulmonology","PRINCIPAL_INVESTIGATOR",{"name":89,"affiliation":90,"role":87},"Rodrigo Hoyos","Hospital Carlos Andrade Marin of Quito, Ecuador",[92,97],{"name":93,"role":94,"phone":95,"phoneExt":61,"email":96},"Silvia Ulrich, Prof. Dr. med.","CONTACT","+41442552220","silvia.ulrich@usz.ch",{"name":98,"role":94,"phone":95,"phoneExt":61,"email":61},"Michael Furian, Prof. Dr. sc. ETH",[100],{"facility":101,"status":61,"city":102,"state":61,"zip":103,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":111,"contacts":61},"University Hospital of Zurich","Zurich","8091","Switzerland","CH",{"type":107,"coordinates":108},"Point",[109,110],8.55,47.36667,{"lat":110,"lon":109},{"type":113,"investigatorFullName":114,"investigatorTitle":115,"investigatorAffiliation":5,"oldNameTitle":61,"oldOrganization":61},"SPONSOR_INVESTIGATOR","Silvia Ulrich Somaini","Prof. Dr. med.","100654267","assessment-of-six-minute-walking-distance-between-sea-level-la-vs-high-altitude-ha-after-re-ascent-in-patients-with-pulmonary-arterial-hypertension-pah-100654267",false,"NCT07797166","Assessment of Six-minute Walking Distance Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH","Effect of a One-week Descent From 2850m to Sea Level and Re-ascent in Patients With Pulmonary Arterial Hypertension and Healthy Controls Permanently Living > 2600m on Pulmonary Hemodynamics, Exercise Capacity, Blood Oxygenation, Sleep Disordered Breathing and Further Outcomes","Inclusion Criteria:\n\n* Adult patients aged 18-80 years and of all genders\n* Permanent residence \\> 2600 m\n* Diagnosis of pulmonary arterial hypertension PAH (PAHHA-Group) according to guidelines\n* Patients are stable on therapy\n* NYHA (new york heart association) functional class I-III.\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>80 years\n* unstable condition\n* Patients who cannot follow the study investigations\n* Patient permanently living \\\u003C 2600m.\n* Patients who traveled and stayed overnight at altitudes \\\u003C2000 m in the past 4 weeks.\n* Patients with moderate to severe concomitant lung disease (FEV1\\\u003C70% or forced vital capacity \\\u003C70%), severe parenchymal lung disease, severe smokers (\\>20 cigarettes\u002Fday)\n* Severely hypoxemic patients at Quito permanently having persistent SpO2 (oxygen saturation by pulseoximetry) \\\u003C80% on ambient air.\n* Patient with a non-corrected ventricular septum defect\n* Relevant concomitant other disease of the heart, kidney, liver, blood (anemia hemoglobin\\\u003C11 g\u002Fdl)","ALL","18 Years","80 Years",{"count":127,"type":128},20,"ESTIMATED","INTERVENTIONAL",[63],"To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on six-minute walking distance and other scores in patients with pulmonary arterial hypertension PAH, who live permanently \\>2600m.",[133,134,135,136,137,138],"Pulmonary Arterial Hypertension (PAH)","Pulmonary Vascular Disease","Six-minute Walk Test","NYHA","High Altitude Effects","High Altitude",[140,138,141,142,136,143],"Hypoxia","six-minute walking distance","Pulmonary Arterial Hypertension","Exercise testing","NOT_YET_RECRUITING","2026-08-27",{"date":147,"type":148},"2026-09-01","ACTUAL",{"date":150,"type":128},"2026-09-25",{"date":152,"type":128},"2026-12-31",{"name":114,"class":6},1]